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Inside Cover Synchronized Synthesis of Peptide-Based Macrocycles by Digital Microfluidics (Angew. Chem. Int. Ed. 462010)

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A. microfluidic technique …
… for synchronized chemical synthesis has been developed and applied to the formation
of peptide-based macrocycles and analogues with side chains appended during ringopening. A. R. Wheeler and co-workers describe this digital microfluidic technique, in
which discrete droplets of samples and reagents are controlled by electric potentials
applied to an array of electrodes coated with a hydrophobic insulator, in their
Communication on page 8625 ff. Artwork: M. Jebrail/S. Youhanna.
Inside Cover
Mais J. Jebrail, Alphonsus H. C. Ng, Vishal Rai, Ryan Hili,
Andrei K. Yudin,* and Aaron R. Wheeler*
A microfluidic technique for synchronized chemical synthesis has been developed and
applied to the formation of peptide-based macrocycles and analogues with side chains
appended during ring-opening. A. R. Wheeler and co-workers describe this digital
microfluidic technique, in which discrete droplets of samples and reagents are
controlled by electric potentials applied to an array of electrodes coated with a
hydrophobic insulator, in their Communication on page 8625 ff. Artwork: M. Jebrail/
S. Youhanna.
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synchronized, microfluidic, macrocyclic, base, int, cover, angel, synthesis, 462010, chem, digital, insider, peptide
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