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Mechanisms of antibody formation. M. Holub and L. Jaroskova. New York Academic Press 1960. 385 pp. 214 illus. 10.00

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MECHANISMSOF ANTIBODY
FORMATION.
M . Holub and L. Jaroskova. New York, Academic
Press, 1960. 385 pp., 214 illus., $10.00.
This volume contains the proceedings of a symposium on antibody formation held in
Prague, May 27-31, 1959. The thirty-three papers presented were divided into six general
topics including the following:
1. The Cells Engaged in Antibody Formation.
2. The Fate of Antigens and the Importance of Different Routes of Administration.
3. The Inductive Phase of Antibody Formation.
4. The Productive Phase of Antibody Formation.
5. Secondary and Non-Specific Anamnestic Responses.
6. Methods of Depressing and Enhancing Antibody Production.
The papers under each of the above topics were preceded by introductory remarks reviewing the general area and setting forth the problems to be discussed under the specific
topics. The introductory remarks serve well to orient those less familiar with the general
area of antibody formation. The papers varied in extent from brief reports on highly selected topics to extensive reviews of broad areas. The majority contained considerable
experimental detail, and a few pertinent references are included in each paper.
One of the most informative and interesting aspects of this book is contained within the
discussion following each topic. Here the participants ( from thirteen different countries)
speculated freely on the theories presented, the reasons for discrepant results and the
direction of future experimentation. In the discussion under the topic of theories of antibody formation, some twelve variant theories were expounded by the different speakers.
One gains the impression that the chief value of these theories is to point to avenues of
future investigation rather than offer any definitive explanation for the mechanism of
antibody formation. It is perhaps unfortunate that a section on the biochemical aspects of
protein synthesis was not included in the symposium.
This symposium illustrates, as Dr. F. M. Burnett points out in his concluding remarks,
that immunology is progressively moving into many areas of biology and is making significant contributions to our understanding of important biological phenomena.
One of the chief values of this book will be to those working in the area of antibody
formation rather than the reader with a peripheral interest wishing a more concise and
B. Tomasi, Jr., M.D.
less detailed review of presently available information.-Z'.
IMMUNODIFFUSION.
Alfred J. Crowle, New York, Academic Press, 1961. 330 pp., 63 illus.,
$10.00.
This book, dealing with a variety of theoretical and practical aspects of immunodiffusion,
readily divides itself into three major parts. In the first chapter the author presents a concise historical account of the development of current methods of immunodiffusion. In it
he places into proper perspective the early observations made around the turn of the
century and the many brilliant advances by many investigators during the past 15 years
in the understanding of the principles of these techniques as well as their practical applications. This section is followed by an up-to-date review of the theory of immunodiffusion
(Chs. 2 and 3 ) and the techniques employed (Ch. 5). These chapters should be of great
help to investigators wishing to employ these techniques, especially in light of the detailed
information supplied in the Appendices which provide valuable and specific information
regarding the preparation of buffers and stains. These chapters taken together serve as an
excellent technical manual which consolidates a great deal of information useful to
workers in the field. The treatment of these subjects is sufficiently detailed to permit those
not previously acquainted with these methods to employ them without difficulty and yet
manages to keep the interest of those using them frequently. The illustrations accompanying these subjects are well planned and supplement the text admirably.
Chapter 4 attempts to discuss a variety of applications of these techniques. This section
proves to be the weakest part of the book since it is difficult to do justice to all of these
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holub, jaroskova, mechanism, formation, antibody, academic, new, york, 214, 385, 1960, pres, illust
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