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J. Pathol. 185: 438?439 (1998)
Electron Microscopy for the Fine Needle Aspiration of
Tumours: a Primer.
G???????? E. Q???????. Karger Landes Systems, Basel,
1997. No. of pages: 191.
In this book the author sets himself the objective of providing a simple but comprehensive review of the neoplastic cell
and its matrix as seen in fine needle aspiration biopsies, for
those starting out in tumour diagnosis who nevertheless have a
basic idea of cell structure. The book is thus intended as a basic
introduction to ultrastructural pathology for cytotechnologists
and residents. It includes introductory sections on the nature
and design of the transmission electron microscope, the historical development of the technique, and the current aspects
of its application to fine needle specimens. The remainder and
bulk of the book are devoted to a compendium of electron
micrographic images of cell and matrix constituents with brief
accompanying legends. The cell structures are grouped into
sections (for example, nucleus, diagnostic membrane-bound
particles, cytoplasmic filaments), each of which has a page or so
of introductory and explanatory text.
Two positive features of this book are readily apparent.
First, it is in a soft-back format, which, in combination with its
size (140215 mm), makes it a handy book. Second, it lies at
the inexpensive end of the price spectrum for books on
diagnostic electron microscopy (about � from Karger in
What cannot be ignored, however, is the inadequate quality
of many of the illustrations, which must be regarded as
significantly compromising the extent to which the author
achieves his objective. The original photographic material may
well have been of excellent quality, but what we see in the book
are many out-of-focus images. For example, one cannot see
the all-important internal lattice in melanosomes, or the
scroll-like configurations in mast cell granules, while other
structures such as the microtubular elements in Weibel-Palade
bodies, intermediate filaments, and the cross-striations of
collagen fibrils lie at the limit of visual identification. In
addition, the arrows pointing out specific structures or features
in a number of the micrographs are not applied with the
precision that a beginner might need.
Of recently published competing works well under the �0
mark, there are books by Dardick et al.,1 Eyden,2 and Leong
et al.3 Dardick et al.?s handbook is for residents and also
includes information on tumour types; Eyden?s book specializes in tumour cell organelle recognition and terminology and
is for both trainees and practising tumour pathologists; while
Leong et al.?s book, in addition to organelle details, includes a
good deal of immunohistochemistry and is also for the practising tumour pathologist. The prospective buyer will need to
assess whether Quinonez?s book provides the right balance of
cost, content, and quality in comparison with these other
B???? E????
Christie Hospital NHS Trust
1. Dardick I, Eyden BP, Federman M, et al. Handbook of Diagnostic Electron
Microscopy for Pathologists-in-Training. New York?Tokyo: Igaku-Shoin
in conjunction with the Society for Ultrastructural Pathology, 1996.
CCC 0022?3417/98/040438?02 $17.50
1998 John Wiley & Sons, Ltd.
2. Eyden BP. Organelles in Tumor Diagnosis: An Ultrastructural Atlas. New
York?Tokyo: Igaku-Shoin, 1996.
3. Leong ASY, Wick MR, Swanson PE. Immunohistology and Electron
Microscopy of Anaplastic and Pleomorphic Tumors. Cambridge:
Cambridge University Press, 1997.
Pathology of the Prostate. Volume 34 in the series Major
Problems in Pathology.
C?????????? S. F????? and D???? G. B???????. W. B.
Saunders Company, Philadelphia.
The authors drawn together by this Anglo-American editorial team are predominantly from America, but with contributions from Canada, Japan, Germany, and Ireland. The
topics covered include embryology and anatomy of the gland,
benign and neoplastic conditions. With respect to the diagnosis
of premalignancy and malignancy, differential diagnosis,
grading, and adjuvant techniques (histochemistry, immunohistochemistry, and DNA flow cytometry) are covered in
detail. Neuroendocrine differentiation, neovascularity, and
chromosomal abnormalities have been singled out for specific
chapters. Correlation between histopathological findings and
serum PSA and imaging, respectively, have been addressed.
Although in vitro and animal models of prostate cancer are
mentioned, individual chapters have not been devoted to
summarizing the wealth of information available from tissue
culture, experimental animals, and comparative anatomy of
the prostate. The aetiology and epidemiology of prostate
cancer are not discussed as separate topics, nor has the
problem of screening for this disease been designated a specific
chapter. Thus, this text is aimed at diagnostic histopathologists
and will be an important addition to their library.
With one exception, the chapters are written in a review
format with numerous clear headings, sub-headings, and useful summaries in some instances. There is overlap in the
content of this book, but this ensures that each chapter is
complete?a useful feature for the majority of readers.
Tables are numerous and helpful. The writing style is clear
and problems are well delineated. There are several teams of
writers which include old and new names, the latter presumably reflecting younger colleagues involved in research. These
arrangements have usually worked very well, but occasionally
one wishes that the authors? enthusiasm for including all the
problems and controversies had been curbed. In only two of
the 23 chapters did I find only minimal help or interest. In one
instance, the topic was oversimplified and in the second,
insufficient effort had been made to adjust the subject for a
pathology readership. Occasional opinions may not be universally accepted; for example, the myoepithelial nature of basal
cells, the cytoplasmic location of androgen receptors, and the
enthusiasm for transrectal ultrasound as a diagnostic investigation for carcinoma. Photomicrographs, usually of a high
standard, are in black and white but with a surprising and
cheering series of 13 colour plates occupying a segment of each
of 3 pages in the centre of the book.
The average list of references per chapter is between 60 and
70. Unfortunately, only a minority of chapters include 1997
references and for many, the literature appears to have ended
in 1995. One author ascribes outdated publications to the
rapidity of technological advance but then abandons the battle
by only giving one reference beyond 1994. This deficiency may
be the result of publishing delays and one never knows whether
the ?97 authors? are the up-to-date set, or merely those who
have held up publication for those whose chapters were topical
when submitted in 1996. Such problems may explain why the
chapter on neovascularity in prostatic cancer is deprived of
Montironi?s contributions and why the work of the Issacs and
Ostrander groups on the importance or otherwise of a susceptibility locus for prostate cancer on chromosome 1 is not
It is difficult to think of a precise and current competitor for
this book. There are valuable atlases, bench books, and
chapters in large texts, but these do not present such a detailed
approach to the prostate. In that many of the authors have
written reviews for journals on topics identical or similar to
their chapters, the decision to buy Pathology of the Prostate
may lie with the contents of your filing cabinet or disc.
1998 John Wiley & Sons, Ltd.
However, the importance and strength of this book lie in the
diagnosis of prostatic disease at a time when it is urgently
required. I suspect that it will be of major value to those
diagnostic histopathologists whose primary interest was not in
prostate pathology, but is rapidly becoming so as they cope
with the increase in clinical activity and questions on this
subject. It will also have a place in the libraries of urology
M. C. P????????
UCL Medical School
University Street
London W4E 6JJ
J. Pathol. 185: 438?439 (1998)
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