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180: 229-230 (1996)
Tumours of the Serosal Membranes, Atlas of Turnour
Pathology. Third series, Fascicle 15.
Washington, DC, and Universities Associated for Research
& Education in Pathology Inc., 1995. ISSN: 0160 6344.
ISBN: 1 881041 19 0.
This 128-page fascicle on mesothelial tumours was accepted
for publication in 1994 and published in 1995. A review in
mid- 1996 is therefore just in time! The authors’ credentials for
this particular area of pathology are impeccable and it was a
pleasure to read the succinct and authoritarian text in most
of this fascicle. Dr McCaughey’s first publication in 1958,
describing 13 cases of pleural tumours ( J Puthol Bacteriol
1958; 7 6 517-529), was from Belfast.
The format is the familiar pale blue soft cover with a mixture
of text, black and white and colour photographs with explanatory sub-titles. The text and figures take up just 125 pages;
there are eight chapters. The first chapter deals with development, anatomy, and function of serosal membranes. I found
this perhaps slightly disappointing and I think that lack of
colour in the line diagrams was a definite handicap. This part
of the text is in the language of embryological texts and does
not clarify anything. The short sections on normal anatomy
and functional processes are good. There is a short chapter on
reactive and healing processes which serves to underline the
difficulties in distinguishing between these and early malignant
change. The newly described entity ‘mesothelial incidental
cardiac excrescences’ (MICE) merits only one paragraph.
More detail about these processes would have been welcome.
The bulk of the fascicle (71 pages), as would be expected, is
devoted to diffuse malignant mesothelioma. I found this
section of great value and anyone who has to deal with
mesothelial tumours will find it of practical help and a comfort
to have on the bench, when brooding over a problem case.
There are 347 references, which form a coherent bibliography.
There is a short introductory section on asbestos fibres and
their relevance to mesothelioma and other tumours. Uses of
asbestos in various commonly encountered products are conveniently tabulated. The variants of mesothelioma are very
clearly listed and defined, with several typical illustrations of
each. Desmoplastic mesothelioma is particularly well dealt
with and its diRerentia1 diagnosis from the fibrous tumour of
the pleura makes good sense.
The section on cytology of mesotheliomas points out the
often ignored fact that smears are representative of a larger
area of the pleural cavity than needle biopsies of the pleura.
The use of iininunohistochemistry, with particular reference to
HBME-1, developed by Dr Battifora and hopefully the first of
several more specific mesothelial markers to follow, is a
particularly valuable section. Its problems are not ignored and
the difficulties with each of the commonly used antibodies,
including p53, are described in detail. There have been some
reports in the literature of CEA-positive mesotheliomas and
the reason for this is clearly explained; this positive reaction
disappears with hyaluronidase pretreatment. The role of electron microscopy is obviously diminishing-there are only four
electron micrographs out of a total of 81 illustrations in this
There is a list of 14 other distinct tumour entities classified in
this fascicle, not all of which are separately described in the
text. Most of these will be familiar to the general reader,
though I found the order of description haphazard. The
8 1996 by John
WiIey & Sons, Ltd.
good-prognosis, well-differentiated papillary mesothelioma
occurring in the peritoneum of young women is dealt with
as a variant of malignant mesothelioma. The primary serous
papillary carcinoma of the peritoneum is dealt with in another
chapter. Various diverse entities are described under ‘Other
tumours’, including ‘mesothelioma’ of the AV node. This
‘congenital heterotopia of endodermal origin’ will presumably
be excluded from future editions. The localized fibrous tumour
of sub-mesothelial origin is well described and profusely illustrated and the absence of cytokeratin as a diagnostic feature is
clearly stated. Towards the end, there is a short chapter on
secondary tumours, followed by a final chapter dealing with
plaques and other non-neoplastic serosal lesions.
This authoritative fascicle can be strongly recommended.
Institule of Pathology
The Queen’s University of Belfast
Pathology of Systemic Lupus Erythematosus.
(Ed.) AFIP and the American Registry of
Pathology. No. of pages: 175. Price: $39.00.
The Armed Forces Institute of Pathology (AFIP) fascicles
have been one of the bedrocks of tumour pathology for
generations of pathologists. Who as a junior pathologist has
not been told to ‘look it up in the fascicles’? The standard
format of high quality micrographs, often in black and white,
with essential descriptive and prognostic information, is a
combination which competitors have struggled to emulate.
The production of a volume on a single inflammatory disease
is an interesting development, justified by the wide range of
organs involved and the spectrum of pathological change.
With an introduction and historical perspective, all the
major organ systems are covered in 13 chapters. The editor,
Dr Tatiana T. Antonovych, is a senior American renal
pathologist and her papers have been distinguished by the
quality, indeed beauty, of the electron micrographs. This
remains true of the chapter on renal disease; it is unfortunate
that the format is too small and much of the detail present will
be missed. Light microscopy in black and white demonstrates
how much information can be conveyed without the use of
colour. Immunofluorescence micrographs are excellent and
support those who still adhere to this methodology, including
the reviewer. The obsessive will note the single bright yellow
micrograph of diffuse IgG, characteristic of overexposure.
Current classifications of renal lupus erythematosus are well
covered and relevant clinical aspects are fully presented.
The remaining chapters of the book are under the authorship of members of the relevant departments of the AFIP. Of
these, the chapter on dermatopathology is particularly well
illustrated with macroscopic colour photographs. The extent
to which literature is discussed is somewhat variable (74
references renal, 7 references skin). The cardiovascular and
musculo-skeletal chapters are also well illustrated and cover
the clinico-pathological aspects well.
Picking out certain sections for comment is not to belittle
other chapters. In all sections the reader will find excellent
illustrations and sound advice. There is, however, some variation both in the presentation and labelling of micrographs
and in the use of personal material. In particular, the use of
four double page spreads for the tabulated information from
1 1 post-mortems seems self-indulgent. The basic strategy of
producing a multi-author volume from a single institute is one
which demands much of authors who may have major interests
in other areas of pathology. An observation which provokes
speculation is that the majority of authors give military rank
and affiliation rather than medical qualification.
In summary, this is a usefd volume. It brings together a
wide range of pathology in a disease with multiple manifestations and it will be widely consulted. Its cost is small by
current standards and it is likely to be found in large and small
departmental libraries.
NICE -October 18-23, 1998
President o f the Congress:
Francis Jaubert, MD
Jacques Hassoun, MD
Guy Perie, MD, Organizing Committee
J.M. Coindre, MD, Scientific Committee
Financial Committee:
Hubert Shill, MD
Nicolas Froment, MD
Marcel Bow, MD
Jacques E. Beurlet, MD
Chantal Donne, MD
European Organizing Committee:
Antonio Lombart-Bosch, MD (Spain)
Bryan Corrin, MD (U.K.)
Gunter Delling, MD (Germany)
Vincenzo Eusebi, MD (Italy)
Rudolph Heimann, MD (Belgium)
Secretariat W, French Division
32 cours Albert Thomas, 69008 LYON (France)
Tel.: (33) 04 78 93 46 - Fax: (33) 04 78 75 43 11
120 avenue Gambetta, 75020 PARIS (France)
Tel.: (33) 01 43 64 77 77 - Fax: (33) 01 40 31 01 65
INTERNET INFORMATION: http: N www. anapath. necker. fr. aip I aip. html
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