close

Вход

Забыли?

вход по аккаунту

?

Изменения слизистой оболочки антрального отдела желудка при Helicobacter pylori-ассоциированном гастрите у населения Якутии.

код для вставкиСкачать
, 2006,
3,
2
616.33-002:579.835.12
.
HELICOBACTER PYLORI145
400
Helicobacter pylori (
(76,1%).
)–
.
HP-
.
Helicobacter
pylori.
B. Marshall
J.R.Warren
50%
[11],
1983 .
(
) – elicobacter pylori-
(HP)
[1].
,
13].
,
.
,
,
»,
–
[12,
1
17
[14],
3,6%,
-
70%
«
» [2].
-
«
»
«
.
,
73,2%.
,
79,3% [15, 16, 17].
41,2%
,
,
.
.
,
,
(
,
)
-
,
,
.
,
.
,
-
145
,
[3].
(
(
)
,
:
[4],
[5],
,
-
.
),
[6].
.
,
-
400-
,
,
-
,
-
,
79 (54,5%)
n=42
n=37) 66 (45,5%)
(
n=31
n=35),
90,9% (60
)
50,3% (73
– 49,6% (72
).
,
.
200.
,
,
-
[18].
.
,
.
( )
[7, 8, 9, 10].
,
-
76,1% (
– 73,4%,
-
– 78,8%).
-
22
.
.
Helicobacter pylori-
.
,
75%
-
.
[19, 20].
,
.
,
97,7%
100%
[21].
86,5%
(
5,4%)
.
85,4%
[22].
-
,
,
11,54%, 10,34%
,
70,97%
85%
,
,
– 66,67%
,
60,0%
:
84,21%
– 100%
.
,
-
(k=0,756,
; k=0,797, p<0,01
),
-
p<0,05
; k=0,751, p<0,05
.
-
,
7,69%
).
,
.
-
,
[23],
,
,
.
.
–
.
(37,93% 30,77%, 15,52%
).
7,69%
2,5
(18,97%
-
,
,
(k=0,879, p<0,01),
(k=0,703, p<0,01)
(k=0,752, p<0,01)
(k=0,642,
p<0,01).
(k=0,874, p<0,01)
(k=0,740,
p<0,01).
-
.
–
(46,55%),
–
-
(46,15%)
17,72%
60
3,8%
.
.
:
,
,
.
,
,
[24, 25].
,
,
-
,
30-39
, -
,
[27, 28].
,
.
.
.
-
,
2
,
30-39
[29].
,
- 40-49
.
-
,
«
,
»,
.
,
:
-
;
;
13,8%
,
.
-
,
,
.
.
-
,
,
,
[17, 26].
(
5%
20%)
,
B. Hollis
H.M. Malaty M.S. Osato
S. Campbell, A. Fraser
1997 . [30], Y. Yamaoka,
(
) 2000 . [31].
-
U
23
, 2006,
.
,
3,
-
,
.
,
-
(p<0,05)
,
-
,
–
.
,
«
»
200
,
.
,
5-
,
20
400
(
.
.
–
),
,
.
736+36,9
(600-910
181,0 +17,3
(90-306
),
31,0+4,7
(21-43
),
)
)
(
(
(
,
)
),
),
(
,
.
.
,
(
40-49
,
(
-
100
2
20-29
-
30-39
) ( <0,05),
30-39
(
-
).
,
.
,
,
)
.
.
,
,
:
,
(R=0,506
(R=0,739
(R=0,735
[18].
,
-
.
,
,
-
(p<0,05)
.
-
p<0,05),
-
51,7%,
53,9% (p<0,05).
,
(R
,
,
,
0,025, 0,404, 0,504 0,516
),
,
.
(R
.
,
,
0,07
(23,61+6,23
, p<0,05),
23,84+5,37
,
-
,
30-39
,
.
.
24
p<0,05)
(R=0,703
,
,
26,06+5,16
(22,36+4,66
p<0,05).
.
p<0,05)
p<0,05).
(R).
25,6%,
.
,
-
,
0,525
0,186);
0,431; RR 0,113
(
0,123).
R0,275);
(
R
0,019
0,432; R(
R 0,029
0,186);
(
0,363; R0,132);
R 0,067
0,351; R,
Helicobacter pylori-
.
.
.
Helicobacter pylori-
,
,
40
,
– 30
,
,
(
,
1
),
.
:
.
-
,
,
,
-
.
Correa,
:
–
[32].
–
–
–
–
-
,
-
,
.
,
,
,
.
1.
.
2.
,
3.
,
.
:
.
-
,
,
.
1. Marshall B.J., Warren J.R. Unidentified curved bacilli in
the stomach of patients with gastritis and peptic ulceration // Lancet.
1984. Vol.1. P.1311-1315.
2. Blaser M.J. In a world of black and white Helicobacter pylori
is grey // Ann. Intern. Med. 1999. Vol.130. 8. P.695-697.
3. Katicic M. Is the only good Helicobacter a dead Helicobacter?
// Med. Arh. 2002. Vol.56. 1. P.17-20.
4.
.,
.,
.
. .:
,
1998. 496 .
5. Feldman R.A., Eccersley A.J.P., Hardie J.M. Epidemiology
of Helicobacter pylori: acquisition, transmission, population
prevalence and disease-to-infection ratio // Brit. Med. Bull. 1998.
Vol.54. P.39-53.
6.
.
:
. M.: Hypoxia Medical Ltd., l993.
331 .
7.
.
(
):
.
.…
.
.
. ., 1984. 18 .
8.
.
//
.
, 2000. . 45-46.
9.
.
(
,
):
.
. ...
.
.
. ., 1992. 24 .
10.
.
,
(
). (
.
):
.
.…
.
.
. ., 1993. 39 .
11. Sipponen P. Helicobacter pylori gastritis - epidemiology /
/ J. Gastroenterol. 1997. Vol.32. P.273-277.
12. Gill H.H., Desai H.G. Helicobacter pylori and
gastroduodenal disorders in India-lessons from epidemiology
[editorial] // J. Clin..Gastroenterol. 1993. Vol.16. P.6-9.
13. Parsonnet J. Helicobacter pylori: the size of the problem /
/ Gut. 1998. Vol.43. 1. P. 6-9.
14.
.,
.
// X
,
, 2003 .:
.
.
2004. . 182.
15.
.,
.
,
//
7Helicobacter pylori.
, 1998.
. 39-40.
16.
.
Helicobacter pylori
//
7elicobacter pylori.
, 1998.
. 40.
17.
.,
.,
.
,
//
7elicobacter pylori.
, 1998. . 42.
18.
.
. .:
, 1984. 288 .
19.
.,
.,
.,
.
III
Helicobacter pylori
//
. 1991. 8. . 73.
20.
.
-
U
25
, 2006,
(
10
2004 .) //
,
,
21.
.,
. 2002.
.
4. . 4-9.
elicobacter
//
-
.
, 1998. . 154-156.
.,
.
Helicobacter pylori
//
,
. 2004.
1. . 33-36.
23.
.,
.
Helicobacter pylori
//
. 1995.
3. . 75-76.
24.
.,
.,
.,
.,
.,
.,
.,
Helicobacter pylori
22.
,
.,
.
//
. 1990. 10. . 9-11.
25. Sjurala M., Sipponen P., Kekku M. Campylobacter pylori
in a sample of Finnish population: relations to morphology and
functions of the gastric mucosa // Gut. 1988. Vol.29. P.909-915.
3,
2
26. Reprogle N.L., Glaser S.L., Hiatt R. A. et al. Biological
sex as a risk factor for Helicobacter pylori infection in healthy young
adults // Am.J.Epidemiol. 1995. Vol.142. P. 856-863.
27. Hill M.J. H.pylori carriage in patients with intestinal
metaplasia and in endoscopial-proven normal controls // Rev. Esp.
Enf. Digest. 1990. Vol.78. 1. P.99.
28. Stolte M., Kroher G., Meining A. et al. A comparison of
Helicobacter pylori and H.heilmanii gastritis. A matched control study
involving 404 patients // Scand. J. Gastroenterol. 1997. Vol.32. P.2833.
29.
.,
.
.
, 2000. 98 .
30. Campbell S., Fraser A., Hollis B. Evidens for ethnic tropism
of Helicobacter pylori // Infect. Immunol. 1997. Vol.65. 9. P.37083712.
31. Yamaoka Y., Malaty H.M., Osato M.S. Conservation of
Helicobacter pylori genotypes in different ethnic groups in Houston,
Texas // J. infect. Dis. 2000. Vol.181. 6. P.2083-2086.
32. Correa P.A. Human gastric carcinogenesis: a multistep and
multifactorial process. First American Cancer Epidemiology and
Prevention // Cancer Res. 1992. Vol.52. P.6735-6742.
K.S. Loskutova
Changes of mucous membrane of a stomach by Helicobacter pylori -associated gastritis
in population of Yakutia
This article presents the research on biopsies of gastric antral mucous membrane from 145 sick by a chronic gastritis and 400 sick
Helicobacter pylori (HP)-associated gastritis by morphometrical method. The high prevalence of
(76,1%) was established. The interrelation
of a HP-infection and changes of a mucous membrane of a stomach was investigated. The changes of the structural elements of the gastric
mucosa with HP-associated gastritis at the population of Yakutia have in the basis the lower thickness of cover and dimple epithelium of
mucous with infringement of its protective properties.
26
1/--страниц
Пожаловаться на содержимое документа