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Male to male transmission of supernumerary nipples

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American Journal of Medical Genetics 73:100 (1997)
Letter to the Editor
Male to Male Transmission of
Supernumerary Nipples
To the Editor:
We read the interesting paper by Tsukahara et al.
[1997] presenting for the first time in the literature a
male to male transmission of supernumerary nipples.
Since this report suggests that male to male transmission of supernumerary nipples is an unusual event, we
searched the data base of the Latin American Collaborative Study of Congenital Malformations (ECLAMC)
[Castilla and Orioli, 1983].
The ECLAMC registered 736 cases of supernumerary nipples with a standardized description of laterality, size, localization with respect to the true nipples,
and family recurrence. Thirty-two cases, 15 males and
17 females, had a mother affected with the same trait,
while 23 cases, 18 males and 5 females, had an affected
father, and both parents were affected in one case.
Thus, even when no deficit of affected fathers transmitting the trait to their sons was registered, the relative frequency of affected fathers transmitting the trait
to their daughters was slightly reduced (x2 4 4.26; P <
0.05).
Considering that: 1) family data were obtained from
the mother; 2) the supernumerary nipple was more frequent in males (sex ratio in 736 cases 4 0.61); and 3)
underascertainment of the less severe cases in our register cannot be discarded, then the deficit of affected
girls, i.e., the daughters of affected fathers, could be a
spurious observation.
Furthermore, since among the 55 pedigrees with at
least one affected parent there was a deficit of bilateral
cases when the father was affected, a careful analysis
*Correspondence to: Iêda Maria Orioli, Depto. Genética-UFRJ,
C.P. 68011, Rio de Janeiro 21944-970, Brazil.
Received 7 May 1997; Accepted 7 May 1997
© 1997 Wiley-Liss, Inc.
of all 736 supernumerary nipple pedigrees will be
needed in order to clarify the segregation pattern of
this trait. Nevertheless, male to male transmission of
supernumerary nipples seems to be a frequent finding.
REFERENCES
Castilla EE, Orioli IM (1983): El Estudio Colaborativo Latinoamericano de
Malformaciones Congenitas: ECLAMC/MONITOR. Interciencia 8:271–
278.
Tsukahara M, Uchida M, Uchino S, Fujisawa R, Kamei T, Itoh T (1997):
Male to male transmission of supernumerary nipples. Am J Med Genet
69:194–195.
Iêda Maria Orioli*
Márcia Gonçalves Ribeiro
Latin American Collaborative Study of
Congenital Malformations
WHO Collaborating Center for the Prevention of
Birth Defects
Curso de Pós-Graduação em Genética
Universidade Federal do Rio de Janeiro
Rio de Janeiro, Brazil
Eduardo E. Castilla
Latin American Collaborative Study of
Congenital Malformations
WHO Collaborating Center for the Prevention of
Birth Defects
Instituto Oswaldo Cruz
Rio de Janeiro, Brazil
Centro de Estudios Médicos e Investigaciones
Clı́nicas
Buenos Aires, Argentina
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nipples, transmission, supernumerary, malen
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