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Antidepressantes Neurochemical behavioral and clinical perspectives Edited by S. J. Enna J. B. Malick and E

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BOOKS
Handbook of Behavioral Neurobiology.
Vol 4, Biological Rhythms
Edited by Jiirgen Aschoff
Plenum Press, New Yo&, 1981
545 pp, illustrated
This fourth volume in a series covering behavioral
neurobiology offers a survey of research in the field of
biological rhythms. Emphasis is on rhythms that have
evolved in adaptation to temporal programs in the environment, which have become part of the genetic makeup of
organisms and can be used by organisms as true clocks. Circadian rhythms are treated in 14 of the 27 chapters. Two
chapters are devoted to human circadian rhythms. In the
second part of the book, several chapters discuss tidal,
lunar, and annual rhythms in humans, insects, and vertebrates.
The study of the physiological mechanisms of circadian rhythms is a rapidly developing field, and the overview
this volume provides on the present state of research will
prove a valuable source of information to those interested
in the field.
John J . Caronna, M D
Department of Neurology
Cornell University Medical College
New York. N Y 10021
Electrolytes and Neuropsychiatric Disorders
Edited by P. E. Alexander
S.P. Medical and Scientific Books, New York, 1981
3 13 pages
This first of its kind monograph is an excellent review of
the relationships between a variety of ions and the
pathophysiology of neuropsychiatric disorders. The 11
chapters, written by 20 noted experts, describe the neuropsychiatric complications of electrolyte imbalance and
other neuropsychiatric maladies associated with abnormalities in the metabolism of aluminum, calcium, copper,
lead, magnesium, and manganese. The effects of lithium on
the metabolism of other electrolytes are also described.
Each chapter contains an extensive bibliography. The book
will be a valuable reference text for primary investigators
and clinicians from a broad range of medical disciplines.
the book is devoted to reviewing the neurochemical actions of antidepressants in terms of their acute and chronic
effects on neurotransmitter metabolism and receptor
binding. It includes a detailed description of various animal
models used for screening the activity of antidepressants.
The last three chapters deal with clinical testing of antidepressants and emphasize the use and effectiveness of
lithium, the relationship of plasma levels of tricyclic antidepressants to clinical efficacy, and a brief description of
the newer, “second-generation’’ antidepressant drugs. The
book is well referenced and will be of value to those involved with basic or clinical research on antidepressant
drugs.
Transmitter Biochemistry of Human Brain Tissue
Edited by P. Riederer and E . Usdin
M a c m i l h Publishers Ltd, London, I980
332 pages
This book represents the edited proceedings of the Symposium on Transmitter Biochemistry of Human Brain
Tissue held at the 12th Congress of the Collegium
Internationale Neuro-Psychopharmacologicum in Goteborg, Sweden, in 1980. It is an excellent review of current
knowledge on human neurotransmitters and a valuable repository of references on the subject. Contributions by
such noted experts as Hornykiewicz and Birkmayer are included. The early chapters provide a detailed description
of methodologies and potential pitfalls associated with
the biochemical assay of human postmortem brain tissue.
A single chapter is devoted to the effects of cerebral
hypoxia-ischemia on neurotransmitters and their related
enzymes and receptors. Later chapters describe the neurotransmitter status of human brain in schizophrenia,
Alzheimer’s disease, Huntington’s chorea, and Parkinson’s
disease.
Neurotransmitters and Their Receptors
Edited by U . Z . Littauer, Y . Dudai, I . Silman,
V . 1. Teichberg, and Z . Vogel
John Wiley and Sons, New York, 1980
5 70 pages
This book presents contributions from more than 100 investigators to a workshop sponsored by the European
Molecular Biology Organization and the Weizmann Institute of Science in 1980.
Antidepressants: Neurochemical, Behavioral
and Clinical Perspectives
Edited by S. J . Enna, J . B . Malick, and E . Richelson
Raz?enPress, New Yo&, 1981
261 pages
William Pulsinelli, M D
This up-to-date review of current theories and methodologies in research on antidepressant medications is written by a group of 23 experts in the field. The first half of
Department of Neurology
Cornell University Medical College
New York N Y 10021
639
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