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Antiepileptic drugs ed 3. Edited by Ren Levy PhD F. E. Dreifuss MB Richard H. Mattson MD et al New York Raven 1989 1 053pp illustrated $ 135

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BOOKS
Reviews
Alzheimer’s Disease: Towards an Understanding
of the Aetiology and Pathogenesis (Current Problems
in Neurology Series)
Edited by D.C . Davzes
London, John Libbey and Company, 1989
136 pp, ilfustrated, $35.00
This small volume succeeds reasonably well, with contributions from British experts in a multidisciplinary research approach to Alzheimer’s disease (AD). The organization, lucidity, and quality of prose are excellent and the illustrations are
good. Noteworthy chapters are those by Esiri on the anatomical patterns of the lesions and by Mann on the pathogenesis
and progression of AD. Both present convincingly the evidence in favor of neuronal connectivity as the basis for progression of the pathological changes.
My criticisms of the book are few. There is the unfortunate and inaccurate implication in thc clinical discussion that
the disea5e is not treatable (“some ‘secondary dementias’ are
treatable . . .”). For a September 1989 publication date, the
167 references in the chapter on neurotransmitter deficits
should have contained more than the five references dated
after 1987 (three by the authors). Outrageous statements do
occur, but are rare (e.g., “. . . neurons containing paired
helical filaments . . . lack a cytoskeleton,” p 55). The index is
appropriate, but there are errors in its phraseology (e.g.,
“granulovascular degeneration”).
Because of publication delay, important issues in A D research are lacking, such as the biology of the amyloid precursor and the issue of “diffuse” or “amorphous” arnyloid deposits versus plaques with abnormal neurites. Also, the chapter
on genetics does not give proper weight to probable genetic
heterogeneity in familial AD. Overall, however, the book
offers a balanced presentation of conflicting data and an ef-
fective exposition of relevant British research, which is often
cited insufficiently in United States publications.
Leonard Berg, M D
Antiepileptic Drugs, E d 3
Edited &y R e d Levy, PhD, F. E. Dreifuss. M B ,
Richard H . Mattson, M D , et af
New York, Raven. 1989
1,053 pp, iflustrated, $135.00
The third edition of Antiepileptic D r q s is an update of this
encyclopedic review of medications used in the treatment of
seizure disorders. The editors effectively achieved their goal
stated in the preface, . . to present in a single source all of
the recent advances and knowledge concerning the antiepileptic drugs, as well as an in-depth review of basic pharmacologic data . . . .”
The scope of the book is extensive, with reviews of new,
old, common, uncommon, and investigational agents. A
systematic approach is applied repeatedly to organize the
material; each drug has its respective chapters, entitled
“Mechanisms of Action,” “Chemistry and Methods of
Determination,” “Absorption, Distribution, and Excretion,”
“Biotransformation,” “Interactions with Other Drugs,”
“Clinical Use,” and “Toxicity.” Eight introductory chapters
review the basics of pharmacokinetics, antiepileptic drug
testing, and clinical applications. A potential drawback of the
volume that may limit use for practicing neurologists is its
design as a pharmacology text, organized by drug. One has
difficulty working from epilepsy diagnosis to best treatment.
Nonetheless, Anliepileptic Drags remains the definitive reference resource for detailed information on this widely prescribed class of medications.
‘I.
Dougb R. Labar. MD. PhD
596 Copyright 0 1990 by the American Neurological Association
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mattson, illustrated, richards, phd, new, antiepileptic, dreifuss, ren, york, drug, levy, 135, 1989, edited, rave, 053pp
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