вход по аккаунту


Aziridines and Epoxides in Organic Synthesis. Edited by Andrei K. Yudin

код для вставкиСкачать
Aziridines and Epoxides in Organic
Edited by Andrei K.
Yudin. Wiley-VCH,
Weinheim 2006.
492 pp., hardcover,
149.00 E.—ISBN
As the editor, A. K. Yudin, states in his
foreword, “Interest in epoxides and
aziridines has been amplified because,
not only are they significant synthetic
endpoints, but they are also tremendously useful synthetic intermediates.
Due to the strain associated with the
three-membered ring, they are springloaded! for reactions with nucleophiles”.
According to the introduction, the
book describes in a fascinating manner
the developments not only in the synthesis of both these classes of small-ring
heterocycles, but also in their reactions.
Appropriately, the treatment of the
latter subject is not limited to the wellknown classical nucleophilic substitution reactions, but also covers many
unusual transformations that are not so
well-established, but are no less amazing.
Of the 12 chapters, four are concerned solely with the synthesis of
epoxides and aziridines. As well as
metal-catalyzed reactions, the chapters
discuss the synthesis of epoxides from
aldehydes, and of both epoxides and
aziridines by methods that are wellestablished but are still active areas of
research. The chapter devoted to the
biosynthesis of epoxides opens fascinatAngew. Chem. Int. Ed. 2006, 45, 5733 – 5734
ing perspectives for the synthetic chemist, and is therefore rightly included in
the book. The biosynthesis of aziridines
is also described in a chapter on the
discovery, biological activity, and biosynthesis of aziridine natural products.
However, the organocatalytic epoxidations of olefins are not included.
It is, of course, impossible to cover
comprehensively in a single book the
applications of aziridines, and especially
of epoxides, as starting materials in
organic synthesis. Therefore, a choice
had to be made as to what subjects to
include. The topics chosen include vinylaziridines and vinylepoxides in organic
synthesis, asymmetric synthesis with
aziridine carboxylates and phosphonates, metalated epoxides and aziridines
in synthesis, catalytic asymmetric epoxide ring-opening, epoxides in complex
molecule synthesis, aziridine natural
products, and epoxides and aziridines
in click chemistry. All these areas of
research are topical, and therefore relevant to researchers interested in epoxides and aziridines. My only criticism is a
consequence of the space limitation of
the book. Some topics could, and
should, have been covered more extensively. As an example, the chapter on
epoxides in complex molecule synthesis
should have been more comprehensive.
The treatment of the very active field of
epoxypolyene cyclizations by cations
and free radicals is much too short in
view of its importance.
Clearly, other editors might have
chosen different topics, but this is
merely a matter of personal taste.
While, of course, it remains to be seen
whether all of the described emerging
areas will stand the test of time, the
book nevertheless represents a fascinating and intriguing description of the
state of the art in the chemistry of
epoxides and aziridines.
All the chapters are written by
leading experts in the field, and one
can feel the excitement of the researchers about their work. The book is therefore a genuine pleasure to read, contains
a large body of useful information, and
contains literature references up to early
2005. The index is well-organized and
greatly facilitates the finding of information.
Aziridines and Epoxides in Organic
Synthesis should therefore be included
in the library of every chemistry department. Experts in the field of catalysis
and organic synthesis in both academia
and industry will value the book as a
very important “spring-loaded” source
of information.
Andreas Gansuer
Kekul*-Institut f-r Organische Chemie
Universit1t Bonn (Germany)
DOI: 10.1002/anie.200685408
Molecular Physics
Theoretical Principles and Experimental Methods.
By Wolfgang Demtrder. Wiley-VCH,
Weinheim 2005.
470 pp., softcover
E 69.00.—ISBN
This book, an updated English translation of an original written in German,
is a textbook on the basic physics of
molecules, with a strong emphasis on the
theoretical analysis of molecular spectra
and how to record them experimentally.
The book assumes that the reader has
some basic knowledge of quantum
mechanics and physical chemistry, but
apart from this addresses students at
both undergraduate and graduate levels.
The field is structured in a way that
one would choose for a lecture: it starts
with the Born–Oppenheimer approximation and the description of electronic
states of diatomic molecules (including a
short description of approximate methods to solve the electronic Schr8dinger
equation), then discusses rotations and
vibrations of diatomic molecules. The
“inverse problem”, namely how to
obtain the potential energy curve from
a knowledge of the molecular energy
levels, is also discussed in some detail.
This first part of the book is completed
by a chapter on spectra of diatomic
molecules, which also covers some general aspects of molecular spectroscopy
such as line widths, Doppler broadening,
and two-photon processes. The 25 pages
: 2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Без категории
Размер файла
164 Кб
andrei, yudin, synthesis, organiz, epoxide, edited, aziridine
Пожаловаться на содержимое документа