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Basic neurochemistry ed 4 Edited by George Siegal Bernald Agranoff R. W. Albers and Perry Molinoff New York Raven 1988 984 pages illustrated $58

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Reviews
Amaurosis Fugax
Edited by Eugene F. Bernstein
New York, Springer Verlag, I988
3 10 pp, illustrated, $75 .OO
This book has as its aim to gather and organize the pertinent
literature on transient monocular blindness. Many of the
chapters recapitulate the seminal works on optic nerve and
retinal ischemia and are rewritten and updated by their original authors. The preface by the editor begins with a barrage
of questions concerning the nature and treatment of
amaurosis fugax,and as one might expect, definitive answers
are not forthcoming. The opening treatise by Hayreh, which
is a superb review of the vascular supply to the eye, is thorough, with material that is otherwise difficult to find in a
single source. The clinical presentation and diagnosis of
amaurosis fugax is discussed from several perspectives by
Gautier, Wray, Caplan, and Seybold. The risk of cerebrovascular disease in patients with anterior ischemic optic neuropathy and retinal stroke is reviewed by Savino. Hayreh's concepts on the chronic ischemic ocular syndrome and anterior
ischemic optic neuropathy are discussed authoritatively, and
Carter also provides an important perspective on the chronic
ischemic ocular syndrome. Review of past antithrombotic
trials is eloquently done by several authors in separate chapters.
The reader has to balance this far-reaching series of reviews with several editorial shortcomings. For example, there
is much redundancy in the material presented. Unevenness
of style is evident: Certain authors were given large topics to
address, whereas others attempted to answer very specific
questions. Hayreh's chapters are stimulating but lack tolerance for the views of other investigators. Near the end of this
volume, after being bombarded with statistics comparing the
natural history of amaurosis fugax and cerebral transient ischemia, the reader will be relieved to find a consensus statement. It opens with an excellent summary of the etiology and
diagnosis of transient monocular loss. Treatment recommendations, however, seem slanted toward surgery in the
absence of definitive data to support carotid endarterectomy
over medical therapy. In conclusion, the contributors to this
book provide a superb review of ocular ischemia, but it is
clear that more controlled data to compare the various
modes of therapy are needed.
Steven L. Galetta, M D
rotransmitter systems. Each chapter includes a description of
the metabolism and neuronal distribution of a specific transmitter (or a logical grouping of transmitters) and a description of receptor subtypes. Three chapters provide an overview of the application of gene cloning techniques to
neuroscience. Authors of additional chapters describe the
cellular integration of molecular processes, review disorders
of the nervous system, and discuss the relationship between
neurochemistry and behavior. All of the chapters are well
organized. The index is inclusive, and references are current
and should be helpful to curious readers. This textbook is
ideal for graduate level courses in neuroscience and
neuropharmacology, and it can be an invaluable tool in the
laboratory as well as in the offices of neurologists or psychiatrists. Basic Neurochemistry is the best available textbook covering these topics.
Mark L. Batshaw, MD
The Heart and Stroke
Edited by Anthony J. Furlan
New York, Springer-Verkzg, 1987
382 pp, illustrated
The Heart and Stroke is divided into five sections and is
strengthened by a lengthy index. The authors of the first and
last sections deal directly with clinical issues concerning the
pathogenesis, diagnosis, and classification of cardioernbolic
stroke. The first section is a thoughtful review of the historical evolution over the last five decades of current views of
stroke of cardiac origin. The authors of the last section review stroke associated with cardiac conditions and cardiac
risk factors in patients with cerebrovascular disease. Authors
of the three middle sections present the clinical neurophysiology of brain and heart interactions, neurogenic control of
the cardiovascular system, and pathophysiological considerations related to cardiac surgery. The books strength is its
merging of clinical perspectives concerning the role of the
heart in cerebral ischemic disorders. It is recommended as a
practical guide to the specialist in cerebrovascular disease and
also as a source of relevant reference material.
Michael Kushner, M D
The Molecular Biology of Neurological Disease
Edited by Roger N . Rosenberg and A . E. Harding
London, Butterworth, 1988
263 pp, illustrated, $45 .OO
Basic Neurochemistry, ed 4
Edited by George Siegal, Bernard Agranoff;R. W . Albers,
and Peny Molinoff
New Yo&, b v e n , I988
984 pages, illustrated, $58.50
Most of the chapters of Basic Neurochemistty have been updated to reflect the tremendous growth in neurochemistry
during the 1980s. As in earlier versions, the book begins
with a basic description of the nervous system and its components, and one chapter is devoted to each of the major neu-
In the recent past, we have seen explosive advances in the
understanding of molecular aspects of differentiation, regulation of cellular function, malignant transformation, and interaction of microbial pathogens with host organisms. The
application of molecular biological techniques to the study of
neurobiology and neurological disease is causing similar
advances in molecular neuroscience. The authors of The
Molecular Biology of Neurological Disease have undertaken the
difficult task of presenting an update of these advances.
Copyright 0 1989 by the American Neurological Association 795
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984, georg, illustrated, 1988, neurochemistry, molinoff, agranoff, new, page, perry, york, alber, basic, bernald, edited, siegal, rave
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