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Book Review Allgemeine und spezielle Pharmakologie und Toxicologie. (General and Specialized Pharmacology and Toxicology). Edited by W. Forth D. Henschler and W

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single entry (p. 507), concerning the catalytic hydrogenation
of aromatic nitro compounds containing “alk-1 -en-I -yl substituents”. It would be wise if the indexes of future volumes
were constructed in a manner more adapted t o their primary
In view of its comprehensive content and clear presentation
this volume can be considered as an important reference work
for problems of synthesis; for organic-chemical libraries it
may be regarded as essential.
Giinter Kresze [NB 294 IE]
Allgemeine und spezielle Pharmakologie und Toxicologic,
(General and Specialized Pharmacology and Toxicology).
Edited by W Forth, D. Henschler. and W Rurnr?ie/.Wissenschaftsverlag, Bibliographisches Institut, MannheimVienna-Zurich, 1975. 606 pp., numerous figures and tables.
bound. DM 78.
In this book 25 authors set themselves the task of describing
the material content of pharmacology and toxicology in relation to one another. Based on the subject list of the approbation
law, the first part is devoted to general pharmacology and
describes the interaction between drugs and living organisms.
These principles make it easier to understand the appreciably
larger second part concerned with the specialized pharmacology of organs and the possibilities available for treating them
with drugs. Further chapters deal with the use of X-ray contrast
media, the chemotherapy of infectious diseases, and the formation and treatment of tumors. An extensive section on poisons
provides the conclusion.
The intention of this arrangement was t o present in
connected form material that is divided during studies between
different departments. All the textual material concerned with
pharmacotherapy is picked out in red. In this way the beginner
who does not yet understand the principles merely has to
turn the pages, while the more knowledgeable reader has
in front of him all that belongs together. The large number
of illustrations, usually in two colors, makes the text very
easy to interpret, while numerous formulas in modern formulation and excellently drawn provide an easy overall view of
the subject.
The reviewer, who is not a medical man, finds the underlying
idea very good indeed. The pharmacological aspects are described with didactic skill and are easy for the general scientist
t o understand. Unfortunately, the information content of the
individual chapters is very varied, as can be shown by comparing the section on endocrine pharmacology with the neighboring section on vitamins: in the former there are clear schematic
illustrations of the mechanisms of action and regulation, and
clear and detailed formulas for the biogenesis and metabolism
of hormones; in contrast, for vitamins only brief indications
are given in the text.
Apart from the section on vitamins, the sections on antimycotin, antiprotozoal drugs, and anthelmintics are underdeveloped from the point of view of the pharmaceutical chemist,
as they are treated in a total of barely three pages and, after
all, hundreds of millions of people suffer continuously from
malaria, bilharzia, or hookworm.
Thus, although the scheme of the book is so illuminating,
it could be greatly improved by thorough revision, which
should not only root out the numerous printing errors and
many wrong formulas but also remove factual errors; for
example, phenazone is very readily soluble in water, chloral
hydrate is not a chlorinated alcohol, tubocurarine is monoquaternary, colchicine is not the same as demecolcine, and if
carboxylesterases really hydrolyze amides such as phenacetin
or salicylamide this should be explained in more detail for
the benefit of the uninitiated.
Angew. Chem. Int. Ed. Engl.
Vol. 15 (1976) No. 2
Thus, the Forth-Henschler-Rummel book in its present form
is an attractively produced and impressive source of information; after thorough revision it would become a first-class
textbook that would probably be in great demand.
Felix Zyrnalkowski [NB 296 IE]
Terpenoids and Steroids, Vol. 5. Senior Reporter: K. H . Orerfon.
The Chemical Society, London 1975. x, 390 pp,, bound,
f 21.00.-A
volume in the series “Specialist Periodica
Chemical Analysis of Organometallic Compounds, Vol. 4. By
7: R. Crompton. Number 4 of the series “The Analysis
of Organic Materials”. Edited by R. Bekher and D. M .
W Anderson. Academic Press, New York 1975. x, 302 pp.,
bound, $ 23.25.
Chemisorption and Magnetization, By P. L. Selwood. Academic
Press, New York 1975. ix, 172 pp., bound, 8 19.50.
Topics in Current Chemistry-Fortschritte der chemischen
Forschung. Vol. 58: New Theoretical Aspects. Edited by
F. L. Boschke. Springer-Verlag, Berlin 1975. iv, 186 pp.,
bound. DM 58.-.
Advances iu Quantum Chemistry, Vol. 9. Edited by P.-0.
L6wdin. Academic Press, New York 1975. x, 304 pp., bound,
Baustoffchemie. Eine Einfuhrung fur Bauingenieure und Architekten. By H . Hennincj and D. Knofel. Kohl’s Technischer
Verlag, Frankfurt 1975. 183 pp., bound, DM 25.--.
Histochemie. Grundlagen und Methoden. By J . C h a ~ ~ L.
Bitensky, and R. G. Butcher. Verlag Chemie, Weinheim
1975. xv, 228 pp., paper, DM 58.-.
Physical Organic Chemistry. The Fundamental Concepts. By
C. D. Rifchie. Vol. 4of the series “Studies in Organic Chemistry”. Edited by P. G. Gassman. Marcel Dekker, New York
1975. vii, 283 pp., bound, $ 16.50.
Statistical Mechanics and its Chemical Applications. By M.
H. Eaerdell. Academic Press, New York 1975. xxii, 305
pp., bound, $ 22.75.
The Elementary Language of Solid State Physics. By 44. H.
B. Stiddard. Academic Press, New York 1975. xii, 188 pp.,
bound, $14.00.
Chemotherapie von Tumoren. Biochemische Grundlagen. By
W E. G. Muller. Verlag Chemie, Weinheim 1975. 155 pp.,
paper, DM 44,
Theory of Orientation and Stereoselection. By K. Fukui. VO~.
2 of the series “Reactivity and Structure Concepts in Organic
Chemistry”. Edited by K. Hufnrr, J.-M. Lehn, C.-W Rees,
P. L‘.R . Schleyrr, B. M . Trost, and R. Zahrudnik. SpringerVerlag, Berlin 1975. vii, 134 pp., bound, DM 44.-.
Physiological and Biochemical Aspects of Heavy Elements in
Our Environment. Edited by J . P. W Houtman and C. J .
A. van den Hamer. Delft University Press, Delft 1975. x,
77 pp., paper, Dfl. 35.-.-Proceedings
of the Symposium
in Utrecht, May 9, 1974.
Flame Emission and Atomic Absorption Spectrometry. Edited
by J . A. Dean and Th. C. Rains. Vol. 3: Elements and
Matrices. Marcel Dekker, New York 1975. xii, 674 pp.,
bound, $49.50.
Halonium Ions. By G. A . Olah. From the series “Reactive
Intermediates in Organic Chemistry”. Edited by G. A. Olah.
John Wiley & Sons, New York 1975. xiii, 190 pp., bound,
$ 22.75.
Mimc Microforms mnual 1976. Featuring Releases of Microforms International Marketing Company and 3 1 Other
Major Micropublishers. Microforms International Marketing Company, A Division of Pergamon Press, Fairview
Park 1975. 296 pp., paper.
The Organic Chemistry of Electrolyte Solutions. By J . E. Gordon. From the series “Interscience Monographs on Organic
Chemistry”. Edited by G. A . Olah. John Wiley & Sons,
London 1975. xxi, 554 pp., bound, E 15.35.
Theoretical Chemistry. Advances and Perspectives, Vol. 1.
Edited by H . Eyring and D . Henderson. Academic Press,
New York 1975. ix, 224 pp., bound, $ 19.50.
Das Verpackungswesenim letzten Viertel des 20 Jahrhunderts.
Ausgewahlte Probleme der Verpackungswissenschaft, der
Verpackungswirtschaft und der Verpackungsinstitutionen.
Edited by H . Prast. Econ Verlag, Diisseldorf 1975. 555
pp.,bound,DM 48.-
Cstalysis Reviews. Science and Engineering, Vol. 11. Edited
by H . Heinemann and J . J . Carberry. Marcel Dekker, New
York 1975. xvi, 325 pp., bound, $32.50.
Crystal Growth from High-TemperatureSolutions. By D. Elwell
and H . J . Scheel. Academic Press, New York 1975. xi,
634 pp., bound, $ 52.25.
Faith, Keyes, and Clark’sIndustrial Chemicals. By F. A. Lowenheim and M . K . Moran. John Wiley & Sons, London 1975.
4th Edit., x, 904 pp., bound, E 26.50.
Structure and Bonding. Edited by J . D. Dunitz, P. Hemmerich,
R . H . Holm, J . A . Ibers, C. K . Jsrgensen, J . B. Neilands,
D. Reinen, and R . J . P. Williams. Vol. 24: Photoelectron
Spectrometry. Springer-Verlag, Berlin 1975. iv, 169 pp.,
bound, DM 68.Physical Chemistry Series Two, Vol. 1: Theoretical Chemistry.
Edited by A. D. Buckingham and C . A. Coulson. From
the series “International Review of Science”. Butterworths,
London 1975. xxvi, 396 pp., bound, E 13.45.
Physical Chemistry Series Two, Vol. 4: Magnetic Resonance.
Edited by C. A. McDowell. From the series “International
Review of Science”. Butterworths, London 1975. 239 pp.,
bound, E 13.45.
physical Chemistry Series Two, Vol. -8: Macromolecular
Science. Edited by C. E. H . Bawn. From the Series “International Review of Science”. Butterworths, London 1975. 303
pp., bound, E 13.45.
Theory of Molecular Relaxation. Applications in Chemistry
and Biology. By F. K . Fong. John Wiley & Sons, London
1975. xvii, 313 pp., bound, E 8.25.
Formula Stencil I1 Stereochemistry/Formelschablone I1 Stereochemie. By B. Schrader and F. Mgtle. Verlag Chemie, Weinheim 1975. Stencil and 16-page text, paper, DM 44.00.
Lehrprogramm Biochemie I: Statische Biochemie. By H .
Schmidkunz and A. Neufahrt. Verlag Chemie, Weinheim
1975. 3rd Edit., ix, 461 pp., paper, DM 26.80.
Initial Rate Enzyme Kinetics. By H . J . Fromm. Vol. 22 of
the series “Molecular Biology Biochemistry and Biophysics”. Edited by A . Kleinzeller, G. F. Springer, and H . G.
Wittmann. Springer-Verlag, Berlin 1975. x, 321 pp., bound,
DM 78.-
Regisrered names, rrademarks, erc. used in this journol, even wirhour specific indicarion :hereof, are nor 10 be considered unprorecred by law.
0 Verlag Chemie. GmhH, D-6940Weinheim. 1976. Printed in Germany by Zechnersche Bnchdruckerei. Speyer/Rhein.
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Angew. Chem. Int. Ed. Engl. 1 Vol. 15 (1976) No. 2
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