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Book Review Anthracycline Antibiotics. Edited By H. S. El Khadem

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M . A . A . Clyne and I . S . McDermid report on laser-induced fluorescence as a method of investigating the electronically excited states of small molecules. Much has
been learned about the dynamic and spectroscopic properties of small molecules and radicals, which have been excited under precise, defined conditions, by means of tunable, narrow band dye lasers. The experimental technique is
also comprehensively described. As much progress has
also occurred in the area of multiphonon excitation with
infrared quanta. D. S . King reports on chemical reactions
influenced by such excitation, molecular dynamics, energy
transport and distribution of excitation energy among the
products following multiquantum infrared excitation.
The subject of the contribution by A . M . F. Lau is laser
predissociation and autoionization by photons. S . R .
Leone discusses the results of single photon ionization and
dissociation of molecules. The distribution of the endproducts, the dissociation time, the fluorescence polarization and the angular distribution of the products allow a
detailed insight into the primary photochemical processes.
Excited metal atoms can pass on their energy in collision
with molecular gases. W . H . Breckenridge and H . Umemoto
report on this area which is of such great importance for
laser technology. I. V. Hertel’s contribution is concerned
with the energy exchange between electronic and vibrational excitation. The measurement of effective cross sections, angular distributions and polarization are discussed.
Exclusively or mainly theoretical methods and results
are discussed by M . Quack (The Reaction Dynamics and
Statistical Mechanics of the Production of Highly Excited
States by High Intensity Infrared Radiation), by D. M .
Hirst (Calculation of the Potential Surfaces of Excited
States) and T. A . Brunner and D . Priichard (Fitting Laws
for the Treatment of Rotation Inelastic Collisions).
Taken as a whole this book allows an insight into the basic concepts and into the latest results in some areas of molecular physics where-because of the advent of the laser-there have been especial advances in recent years. The
individual contributions are well written, fit quickly and
understandably into the general scheme, and include a tremendous number of literature references. Such books are
of inestimable value to the molecular physicist and the
physical chemist. The production is excellent, the price acceptable.
H. C. Wolf [NB 582 IE]
Physikalisches Institut
der Universitat Stuttgart
Electrical Properties of Polymers. Edited by D. A . Seanor.
Academic Press, New York 1982, xi, 379 pp., bound, $
52.00.
The tendency of publishers to assemble a range of individual reports of varying quality and with only a slight
connection with each other and to market them is unfortunately increasing. This book is an example of the abuse.
In the first chapter D . A . Seanor gives a cursory review
of electrical phenomena, measuring techniques and the
electrical properties of various material classes and states
of aggregation of polymers, under the title “Electrical
Conduction in Polymers”. The polymers with metal-like
conduction (e.g . the polyacetylenes), which are decisive in
recent work, are only mentioned here, as in the rest of the
book, in passing. The section on ionic conduction in polymers is interesting, although, here too, there is no menAngew. Chern. Int. Ed. Engl. 22 (1983) No. I 1
tion of the PEO salt complexes which are relevant for electrochemical applications.
It is characteristic of the quality of the article and of the
book in general that the problem of the connection between the electrical properties and morphology of partially
crystalline polymers are discussed in terms of an outdated
model proposed by Flory (not Florey as given in the legend
to Fig. lo!) dating from the year 1953!
Under the ambitious title “Structure and Charge Generation in Organic Molecular Self Assemblies”, J . H. Perlstein deals in Chapter 2 (30 pp.) solely with thiapyrylium
salts dispersed in polycarbonate. It becomes clear that not
even the structure of the interstitial complex has been unequivocally established.
The topic “Photophysical Processes, Energy Transfer
and Photoconduction in Polymers” is treated by R . F. Cozzens in ca. 30 pages in Chapter 3. Without going into details there is a very elementary introduction, attended by a
plethora of historical citations concerning the photoconductivity of polymers and its technical application.
Chapter 4 (80 pp.) by V. Y. Merrit, entitled “Photovoltaic Phenomena in Organic Solids”, devotes all of 11 lines
to the subject of polymers. The author’s remark that polymers behave in a very complex manner is diverting in the
context of this book.
The subject matter of the 5th chapter by H. Carr (20 pp.)
has been treated several times recently in other monographs and progress reports. The same applies to the remaining chapters of the book; in some cases similar reviews have recently been published elsewhere by the same
authors. An example is G. M . Sessler’s contribution “Polymeric Electrets” in Chapter 6 (40 pp.). The two remaining chapters deal with “Contact Electrification of Polymers” ( D . K . Davies, 40 pp.) and with “Dielectric Breakdown Phenomena in Polymers” (P. Fisher, 45 pp.).
Whoever buys this book will at least enjoy its solid getup
and the careful work of the bookbinder.
Gerhard Wegner [NB 591 IE]
Institut fur Makromolekulare Chemie
der Universitat Freiburg
Anthracycline Antibiotics. Edited by H. S . El Khadem. Academic Press, New York 1982. xii, 285 pp., bound, $
25.00.
This volume is a compilation of the presentations at the
Anthracycline Symposium held in New York in August
1981. The choice of topics takes account of the interdisciplinary character of anthracycline chemistry-ranging
from pharmacology through microbiology to total synthesis.
In the first report Narayanan et al. present the National
Cancer Institute’s (NCI) screening programme for anthracycline derivatives. Besides an introduction to the evaluation of screening results a good summary is given of the
range of substances (ca. 400) prepared to date by derivatization of daunorubicin. Scientists not working in the field
will note that the NCI’s screening results occasionally differ from those of other groups. Next Arcamone et al. report
on the results of investigating doxorubicin (adriamycin).
The group from Farmitalia has made important contributions, both in the area of structure effectivity relations and
in the isolation and synthesis of new glycosides. It is sufficient here to mention the syntheses first reported of a
furanoglycoside and of enantio-4-demethoxydaunorubicin
which, as expected, is biologically inactive. T. Oki summarizes the work of the Sanraku Ocean group in his contribution. This Japanese company is to be thanked for the
895
isolation and structural characterization of dozens of new
anthracyclines derived from aclavinone. The microbiological investigations of Umezawa et al. are included, which
concern the microbiological glycosidation by particular
Streptomyces mutants. A further report on industrial research (Upjohn) is given by Wiley in his review of nogalamycin chemistry. Even though nogalamycin derivatives
originally did not belong to the favorites of the pharmacologists, the Upjohn workers have succeeded in synthesizing
a derivative (7-con-0-methylnogarol) which has a comparatively low cardiac toxicity. Interestingly enough this derivative only interacts slightly with double-stranded DNA,
which throws new light on the mode of action of anthracycline antibiotics. The systematic variation of the natural
products, daunorubicin and doxorubicin, is the main
theme of a report by Acton et al. The discussion of the
chemical derivatization is closely linked with the biological
action and with pharmacological considerations. Probably
the most important result is that the N-alkylated derivatives of the natural products do not exhibit mutagenicity.
Mainly synthetic themes are treated in the second portion of the volume. Firstly, Kende et al. and Swenton et al.
describe the results obtained by their groups in the area of
aglycone synthesis. Kende concentrates on 1l-deoxy-anthracyclines of the aclavinone type, while Swenton presents the daumomycinone synthesis via quinone acetals developed by his group. Although the work of other groups is
naturally only mentioned in passing, both reports provide
a deeper insight into the basic synthetic concepts. The
great enthusiasm of both authors comes through to the
reader. Finally, there are three presentations from Horton,
Monneret and El Khadem concerned with glycoside syntheses. Although the problem of monoglycosidation seems
to be basically solved (even for nitrogen-free sugars), the
synthesis of the di- and the trisaccharides is only just beginning. The reviewer applauds the fact that the difficult
chapter on oligosaccharide synthesis, partly with very rare
sugars, is presented as a summary, even though some problems concerning yield and selectivity have not been completely solved.
The volume is very carefully edited and arranged; the
reviewer could find only a few mistakes. The anthracycline
chemist is stimulated by the results of well-known workers
presented from their own personal viewpoints. In particular the summary of the work from the industrial laboratories facilitates literature studies. However, the book can be
recommended not just to specialists. The clearly arranged
presentation provides a rapid introduction to a fascinating
chapter of interdisciplinary research.
Karsten Krohn [NB 587 IE]
Institut fur Organische Chemie
der Technischen Universitat Braunschweig
Phase Transfer Catalysis. 2nd improved and supplemented
edition. Edited by E. Dehmlow and S . Dehmlow. Verlag
Chemie, Weinheim 1983. xiv, 386 pp., bound, DM
138.00.-ISBN 3-527-25897-3
Sicherheit in chemischen und vemandten Laboratorien.
Edited by F. Heske. Verlag Chemie, Weinheim 1983. 128
pp., stitched, DM 46.00.-ISBN 3-527-26066-8
Ellis Homood Series in Chemical Science: Chemical Nomenclature Usage. Edited by R. Lees and A . F. Smith. Ellis
Horwood Ltd., Chichester 1983. 172 pp., bound, X
19.50.--ISBN 0-85312-368-3
Organic Chemistry Series. Vol. 1: Stereoelectronic Effects
in Organic Chemistry. By P. Deslongchamps. Pergamon
Press, Oxford 1983. xi, 375 pp., Paperback, X 15.25.ISBN 0-08-029248-8
Ettore Majorana International Science Series. Bioelectrochemistry I: Biological Redox Reactions. Edited by G.
Milazzo and M . Blank. Plenum Press, New York 1983.
vi, 348 pp., bound, $ 52.50.-ISBN 0-306-41340-X
Das Bergban-Handbuch. Fourth edition. Published by the
Wirtschaftsvereinigung Bergbau e. V. in Bonn. Verlag
Gliickauf GmbH, Essen 1983. 312 pp., bound, DM
54.00.- ISBN 3-7739-0396-0
Das g r o h Werkbuch Elektronik. 4th completely revised
and improved edition. By D. Niihrmann. Franzis-Verlag
GmbH, Munchen 1983. 1218 pp., bound, subscription
price until 31. 12. 1983 DM 88.00, after 1. 1. 1984 DM
108.00. -ISBN 3-7723-6544-2
Progress in Organic Chemistry. An Appreciation of Henry
Taube. Vol. 30. Edited by S. J. Lippard. John Wiley,
Chichester 1983. xii, 528 pp., bound, & 61.75.-1SBN 0471-87022-6
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896
Angew. Chem. Inr.
Ed. Engi. 22 (1983) No. I 1
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