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Book Review Anwendungen der kernmagnetischen Resonanz in der Organischen Chemie (Applications of Nuclear Magnetic Resonance in Organic Chemistry). By H. Suhr

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x,
IS labeled dt the amino end Wlth a group
SO that Aterminal fragments can be easily identified Suitable groups
are the trifluoroacetyl, trideuteroacetyl, and CF2B;CO
derivatives, which permit an unambiguous assignment of
the mass numbers, owing to the constant isotope ratio. The
structure of a linear molecule is established when the fragments containing the introduced group, the possible mass
numbers of which can be programmed, have been identified.
X N H - C H R C O v N H C H R C O Y N H C H R COOH
(n)
N H CHR+co
(h)
NH CHR+Co
N H CHR
Depending on the peptide in question, the fragmentation
proceeds almost exclusively in accoidance with ( ( I ) or (b). ;
Biochem. biophysic. Res. Commun. 23, 381 (1966) ‘ -Mo.
[Rd 583 IE]
BOOK REVIEWS
Zahlentafeln zur Elementaranalyse (Tables for elementary
analysis). By C . Ege. Verlag Chemie GmbH.. Weinheimi
Bergstr. 1966. 1st Edit., xxviii, 356 pp., plastic cover, DM
30.-.
The conversion of the percentages found in the elementary
analysis of organic compounds into the empirical formula
involves a relatively lengthy routine calculation. T o avoid
this, H a f t et al. published a reference work more than ten
years ago (for nitrogen-free compounds up to CSO,atomic
weight basis O=16). This work is now supplemented by Ege’s
tables, which also cover compounds containing nitrogen.
Ege has used a new arrangement for the percentages (compounds up to C40; basis: 12C=12), which greatly simplifies the
work involved in searches; even in his first “emergency”, the
reviewer was able to find the correct formula immediately.
Very well-chosen and well discussed examples in the “explanations” also provide for cases in which t t e indices of a
formula have a common factor; such cases, as in Hart’s
book, are not given directly in the tables i.e. C12H1803 is
found only under C4H60, so that the molecular weight
differs from that found.from the mass spectrum or by titration. The use of other information, such as is often available
in practice, is also discussed to enable the reader to make the
maximum use of the data given.
A new feature is the inclusion of the Beynon unsaturation
number R, which the computer h a s calculated from the H
deficit and which gives the number of rings (and multiple
bonds); this can be very useful in the establishment of possible structures.
Thus the new tables are found to be extremely useful; since
the computer has expressed its results directly, the tables
can claim to be “infallible”. Mistakes of the kind that the
reviewer found in another book of tables (Sfout, Composition tables), namely, that all the values given for Cs4 to C120
are wrong since the computer found no position for the thousands digit and simply left it out, d o not occur in Ege’s book.
F. Kuffner [NB 545 IE]
Anwendungen der kernmagnetischen Resonanz in der Organischen Chemie (Applications of Nuclear Magnetic Resonance in Organic Chemistry). By H. Suhr. Organische
Chemie in Einzeldarstellungen (Organic Chemistry Monographs). Vol. 8. Springer-Verlag. Berlin-Heidelberg-New
York 1965. 1st ed., viii, 424 pp., 123 illustrations, 110
tables, cloth D M 68.- (co. $17.-).
This book starts with a simple introduction to N M R and is
intended for those coming into contact with this method for
the first time. It is also intended as a primer in the evaluation
of spectra of organic compounds and presents comparative
data for this purpose. Thus the author makes no attempt at a
rigorous deiivation of the observed patterns from theory; he
touches only lightly o n the technique of measurement and on
the preparation of the sample, and he writes not so much for
the physical chemist or spectroscopist as for the organic
chemist who requires N M R for structural determinations,
but cannot study it in full detail. For the last-named audience,
this is an easy to follow and recommendable book.
Angew. Chem. internat. Edit. 1 Vol. 6 (1967) 1 No. 3
The first 73 pages describe the main features of chemical
shift and spin coupling. The two sections on the theory of
T and J values (p. 28 and p. 45) are kept qualitative, and
fulfil their purpose admirably. The chapter on splittings of
higher order should have explained in greater detail the
practical procedure in the analysis of spectra. It is repeatedly
suggested that theoretical spectra should be constructed
with the aid of equations or tables. However, it is much less
time-consuming to leave this work to a computer; a short
description of the programs available for this purpose
appears more to the point than the reproduction of rarelyused tables from the literature (27 pp.).
The special part of the book dealing with proton resonance
(172 pp.) is arranged according to classes of compounds.
The considerable amount of experimental data and references
collected makes this book an excellent source of quickly
accessible reference value. However some of the many
useful tables could have been improved with respect to the
clarity and unambiguity of the data presented (e.g. p. 87,
p. 93, and p. 134) A separate chapter (43 pp.) is devoted to
nuclei other than the proton which are important in organic
chemistry. The book closes with 77 pages describing a
number of special application The topics discussed include
solvent effects, hydrogen bonds, substituent effects, equilibria
of all types, and conformation of cyclohexanes. The many
references to methods of simplifying complicated spectra
deserve special mention, since the success of structural determinations often depends o n such simplifications.
The book contains many useful formulae and illustrations.
The literature is covered up to the end of 1964, and in some
cases t o early 1965.
A. Mannschreck [NB 531 IE]
Fortsehritte der Chemie organischer Naturstoffe (Progress in
the chemistry of organic natural products). Edited by
L. Zechmeister. Vol. 23. Springer-Verlag Vienna-New
York 1965. 1st Edit., viii, 397 pp., 58 figures, cloth DM
93.60.
Chemists interested in natural products will welcome thc
publication of any new volume of “Fortschritte”, and
Vol. 23 [*I certainly will be of great benefit to the reader.
In a survey of the polysaccharides of marine algae, S . Peur
and J . R.Turvey discuss not only the chemistry of these
compounds, but also their relation to the polysaccharides of
higher plants. However, their biosynthesis is not mentioned.
On the other hand, H . Schlubach’s contribution on carbohydrate metabolism in barley, oats, and millet deals not
only with the constitution of the polyfructosans, but also
with the enzymatic control of polyfructosan formation. It is
interesting to note that the grains preferentially cultivated
by man are those in which the amount of polyfructosans is
greatest. F. Schkenk makes a successful attempt to explain the
properties and functions of the biological sulfonium compounds on the basis of their redctions. The experiments,
which show that, in some cases of transmethylation, only
[*) For a review of Vol. 22 see Angew. Chern. 78, 554 (1966);
Angew. Chern. internat. Edit. 5 , 529 (1966).
275
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