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Book Review Carbocyclic Non-Benzenoid Aromatic Compounds. By D. Lloyd

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opments and in describing them in a comprehensive manner,
while giving a short account of promising, but as yet little
tested techniques.
The individual chapters are very detailed, and are well suited
for providing information to workers in other fields. Quite
deliberately, attention has been directed to the preparation
or purely chemical analysis of protein and peptide mixtures
that can be accomplished without the need for elaborate
instrumentation - with the possible exception of amino-acid
analysis. Physicochemical methods have been left in the
background. A somewhat wider-based presentation of the
radioactive labeling of proteins would perhaps be desirable,
for example with enzyme substrates, and also the analysis of
the peptides and amino-acids of their labeled derivatives.
Where several proved methods are available for achieving a
particular aim, as for the determination of N-terminal sequences, all are described with equal thoroughness.
The book has been produced with care, and the printing, the
high-quality illustrations, and the arrangement combine to
make it very lucid. The abundance of material which it
presents recommends it highly to everyone interested in
H. Fasold
[NB 633 IE]
protein methodology.
Microbial Transformations of Steroids. By A . eapec, 0. HanC,
and M.Tadra. Translated from the Czech by 0. Macek,
L. Urbanek and 0 . Hanc‘. Dr. W. Junk, Publishers, Den
Haag 1966. 1st Edit., iv, 253 pp.. bound Dfl. 25.OOjS 6.95.
The conversion of steroids by microbial enzymes has been
intensively investigated by numerous groups of workers
during the past decade, and has led not only to scientifically
interesting information but also to practically useful results.
Although no detailed classification of papers published in
scientific periodicals, reviews, and patents has yet been carried
out, the present monograph attempts to rectify this omission.
The brief introduction is followed by a discussion of the types
of microbiological reactions and of reaction mechanisms. In
this, the authors have not relied on speculations. Next comes
a brief discussion of the influence exerted by the steroids on
microorganisms. The practical hints concerning fermentation
are very helpful. A detailed treatment of the analytical
methods, identification, and constitution-determination
methods is unnecessary, because all these are well known.
N o fundamentally new aspects arise in bacterially produced
steroids. The necessity for determining physical data such as
the melting point, optical rotation, and light absorption is
taught to every student at the outset of his practical organic
chemistry course, and in addition the treatise “Steroid
Reactions” by C. Djerassi (1963) provides exhaustive information about chemical methods in steroid chemistry.
The sections that classify the microorganisms according to
their reactions are very useful, as are the lists of steroid
metabolites (together with physical data and the nature of
their preparation) and the comprehensive bibliography (unfortunately reaching only to the end of 1963) which includes
patent literature. This carefully produced work will render
valuable service t o both expert and outsider wishing to
employ microbiological reactions. c h . Tamm W B 648 IE]
can no longer be discussed without recourse to the chemical
and morphological principles of bacteria as a basis.
The great value of this book lies in the detailed treatment of
the biophysical aspects of bacteriology, which will become
increasingly important with further research. The biophysical
side of the various problems of bacteriology is familiar to
very few microbiologists, so that this book is also a very
welcome addition to the literature on bacteriology. The problems discussed are taken largely from the fields in which the
authors work: this on the one hand is a guarantee of authenticity, but o n the other leads to a rather unbalanced selection
of material.
Both authors give a neat account of the biophysical principles
of the intact bacterial cell, hardly touching on the biophysical
problems of molecular biology. In their opinion the situation
prevailing in intact cells must be elucidated before one can
proceed into the molecular-biological domain. The idea that
the reverse route may also be possible is evidently familiar
[NB 606 IEI
only to the younger generation. H. Ziihner
Carbocyclic Non-Benzenoid Aromatic Compounds. By D .
Lloyd. Elsevier Publishing Company, Amsterdam-LondonNew York 1966.1st Edit., x, 220 pages, 2 figures, Dfl. 35.00.
The present monograph is intended as a concise presentation
of the existing knowledge on non-benzenoid carbocyclic
aromatic compounds. In the introduction (15 pages), a
recapitulation of the historical development of the concept of
“aromaticity” is followed by a description of the results of
the molecular orbital theory that are of greatest importance
to the preparative organic chemist. The next few chapters
deal with derivatives of cyclopropene (19 pages), cyclobutadiene (20 pages), cyclopentadiene (43 pages), tropylium salts
(19 pages), tropone and tropolones (45 pages), cyclooctatetraene and cyclononatetraene derivatives as well as annulenes
(19 pages), and polycyclic compounds (35 pages), in particular
the azulenes. The choice of material is generally reasonable,
though the space devoted to the various classes of substances
is not always in keeping with their importance. For example,
the fulvenes are dismissed in 6 pages, whereas 45 pages are
given to the tropones and tropolones.
I n each section, the author describes in a readily understandable manner the methods of preparation, properties, chemical
reactions, and principal spectral data. Each chapter is followed by a list of references, the total number of entries for the
book being about 1000 (literature up to 1965). In comparison
with other books on the same subject, a particularly pleasing
feature is the clear formulation of the reactions, though no
preparative details are given and the spectroscopic findings
are not discussed. The inclusion of spectra of some characteristic compounds would undoubtedly have been helpful.
No previous theoretical knowledge is required in order to
read the book, which can be recommended to chemists who
wish to gain a general picture of recent results in the field
of carbocyclic non-benzenoid aromatic compounds.
M . Neuenschwander
[NB 608 IE]
Growth, Function, and Regulation in Bacterial Cells. By A . C .
R . Dean and Sir C . Hinshelwood. Clarendon Press: Oxford
University Press, Oxford 1966. 1st Edit., xii, 439 p3ges,
120 figures, 29 tables, 2 plates, 84s.
Methods of Elemento-Organic Chemistry. Edited by A . N .
Nesmeyanov and K. A . Kocheshkov. Vol. 1: The Organic
Compounds of Boron, Aluminum, Gallium, Indium, and
Thallium. By A . N. Nesmeyanov and R . A . Sokolik. North
Holland Publishing Company, Amsterdam 1967. 1st Edit.,
xiii, 628 pp., 40 illustrations, 27 tables, Dfl. 87.-.
In 1946, Sir C . Hinshelwood published a book entitled “The
Chemical Kinetics of the Bacterial Cell”. The present volume
is based on the same material with the contents brought up
to date. It would probably have been better to retain the old
title, instead of arousing unfounded hopes by a title that does
not agree with the contents. The book is by no means an
introduction to the problems of the growth, function, and
regulation of the bacterial cell. Nowadays, these problems
The first volume of this new series was published in 1964 by
Nauka Press in Moscow and has been partly revised for
translation into English. The various sections (e.g. boron
362 pp.; A1 140 pp.) of the book are mostly arranged according to methods of synthesis; for boron and aluminum,
compounds without a metal-carbon bond are included. In a
few sections, e.g. chapters 10-12 and 15 on boron compounds
and in chapter 8 o n aluminum compounds, division is
156
Angew. Chem. internat. Edit.
Vol. 7 (1968) j No. 2
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