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Book Review Chemical Carcinogens. Activation Mechanisms Structural and Electronic Factors and Reactivity. Bioactive Molecules Series Vol. 5. Edited by P. Politzer and F. J

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of the recent work of S a g a and of K i n d that has indicated
there may be three stages in the induction of these tumors,
each mediated by a separate chemical. Such deficiencies in
information limit the value of the book mainly to those who
already have a working knowledge of the chemical induction
of cancer. It greatly reduces the value of the book all not so
well versed in the background of carcinogenesis.
The individual topics in this volume are very well presented, with an abundance of charts and figures to convey the
basic data. The interactions described are of major importance in the practical sense, and impinge on many areas of
importance to the general human environment. For example, experimental studies on combination effects in inhalation carcinogenesis, the effects of ethanol, interactions between low levels of potent carcinogens that affect the same
tissue, combinations of carcinogens and non-carcinogens,
interactions between the various components of cancer chemotherapeutic agents used to treat human cancer, interactions between the different components of cigarette smoke,
and the all-important subject of the influence of diet, stressing the possibly greater importance of total calories consumed than of fat, are each carefully considered.
Overall, this volume will prove to be of value to those
experienced in carcinogenesis, especially in relation to its
bearing on the human environment. It will achieve its full
potential if it persuades a dedicated group of scientists to
attempt to organize the entire literature of interactions in a
rational and comprehensive manner.
David B. Clayson [NB 940 IE]
Toxicology Research Division, Bureau of Chemical Safety
Food Directorate, Health Protection Branch
Health and Welfare Canada
Ottawa (Canada)
Chemical Carcinogens. Activation Mechanisms, Structural
and Electronic Factors, and Reactivity. Bioactive Molecules Series, Vol. 5. Edited by €’. Politzer and E J. Martin,
Jr., Elsevier, Amsterdam 1988. xiv, 366 pp., hard cover,
HFI 280.00. -ISBN 0-444-43008-3
Since 1978 an “Interdisciplinary Cancer Research Workshop” has been held annually at the University of New Orleans. Following the tenth meeting it was decided to publish
a detailed report to mark the first decade of this conference.
This book is the result. It consists of 15 chapters dealing with
the most important aspects of research on chemical carcinogenesis: 1. Metabolic and chemical activation of carcinogens: an overview; 2. Reactive metabolites of carcinogens
and their interactions with DNA; 3. DNA adducts in vitro
and in vivo; 4. Carcinogenic halogenated aliphatic compounds; 5. Chemistry, reactivity and carcinogenicity of chloroethers; 6. Carcinogenicity of ethylene and its derivatives:
structural considerations; 7. Reactions of vinyl chloride and
its metabolites with bases in nucleic acids and the potential
biological consequences; 8. Computational studies of olefin
and epoxide carcinogenicity; 9. Irregularities of DNA structure and their effects on DNA replication; 10. Nucleic acid
alkylation by N-nitroso compounds related to organ-specific
carcinogenesis; 11. Nitro-polycyclic aromatic hydrocarbons:
structural features, genotoxicity, and risk evaluation;
12. Methyl bay region diol epoxides: key intermediates in the
metabolic activation of carcinogenic methylated polynuclear
aromatic hydrocarbons; 13. Estrogen carcinogenicity: hormonal, morphologic and chemical interactions; 14. Theoretical implications of the k, carcinogen-screening test; 15. A
Q VCH Verlugsgesetischafi mbH, 0-6940 Weinheim, 1989
microspectrofluorimetric study of the cell’s multiorganelle
detoxification complex and intracellular carcinogen interactions.
The book reports the latest state of knowledge, since all
the chapters have been prepared by acknowledged experts in
their respective fields. Direct reproduction of the original
typescripts has ensured rapid publication. This technique is
known to reduce the likelihood of having a good key-word
index, a Pact which is also confirmed here: the index is less
than four pages in length. Thus, “Aflatoxin” is missing, as is
“2-Aminofluorene”, to give only two examples. Careful
scanning of the detailed contents list is therefore needed in
order to find a given subject of interest, and it should have
been possible to do better than this! Despite this failing the
editors have put together a collection of articles which every
chemist who is interested in chemical carcinogenesis should
have-and their number should increase. The price of the
book, however, is rather high.
Gernot Boche [NB 977 IE]
Fachbereich Chemie
der Universitat Marburg (FRG)
Angular Momentum: Understanding Spatial Aspects in
Chemistry and Physics. By R. N . Zare. Wiley, New York
1988. xi, 349 pp., hard cover, $39.95. -ISBN 0-47185892-7
This book by Richard Zare is based on the Baker Lectures
which he gave in 1980 at Cornell University, and on lectures
given to post-graduate students at Stanford University in the
following years. It is a gem amongst the excellent books that
have emerged over a period of many years from the celebrated Baker Lectures; many chemists will be familiar with C. K.
Zngold’s “Structure and Mechanism in Organic Chemistry”
(1953), and with Linus Pauling’s “The Nature of the Chemical Bond”, which were products of the early years of this
lecture series.
The aim of the book is to give the reader a sound and
detailed understanding of angular momentum in atomic and
molecular physics. It begins by introducing angular momentum operators and wave functions. Chapter 2 treats the case
of coupling between two angular momentum vectors, and
Clebsch-Gordan coefficients. Chapter 3 contains a very detailed treatment of rotational transformations. Chapter 4
deals briefly with couplings involving more than two angular
momentum vectors (with 6 and 9 j symbols), and Chapter 5
describes tensor operators. Finally Chapter 6 treats the energy levels and wave functions of a rigid rotor. The appendix
gives some short Fortran programs for numerically evaluating 3, 6 and 9 j symbols.
The book is a masterpiece of didactic clarity. By means of
numerous carefully set out exercises and examples from
atomic and molecular physics, it enables the reader to work
systematically through the material, and to gain an effective
“practical” understanding of the subject. In this respect the
book differs markedly from the many which adopt a more
rigidly formal approach to angular momentum theory.
Richard Zare’s approach is aimed not at theoretical physicists but at experimentalists, spectroscopists and chemists.
Nevertheless, theoreticians too would benefit from the many
examples of applications. Zare develops all the important
basic theory needed, and the book is therefore eminently
suitable for individual study or for reading in conjunction
with a course of lectures. However, nuclear spin is treated
very scantily from a chemist’s point of view.
Angew. Chem. Inl. Ed. Engl. 28 (1989) No. 7
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