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Book Review Chemie der Eiweisskrper (The Chemistry of Proteins). By E. Waldschmidt-Leitz and O. Kirchmeier

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have liked to see a reference to the work of Brown and Djerassi 121, which forms a good supplement to this section of the
book.
The work presented to date on the mass-spectrometric behavior of organic substances has shown that mass spectra are
determined by the heteroatoms and the functional groups.
In discussing mass spectra, the authors have therefore
classified the organic compounds according to their heteroatoms, as hydrocarbons and compounds of oxygen, nitrogen,
sulfur, halogens, boron, phosphorus, and silicon. I t is understandable that this classification is somewhat arbitrary if
several different heteroatoms are present in the molecule.
However, the index a t the end of the book simplifies the
search for a particular class of compounds.
The important characteristics necessary for identification and
structural analysis are here presented more forcibly than in
similar works, without necessarily a full discussion of the
mechanism by which the fragments are formed. The treatment covers not only the mass spectra of monofunctional
compounds, which gave a particularly clear picture of fragmentation, but also the mass spectra of polyfunctional compounds and natural products with complicated structures,
such as steroids. The methods of mass-spectrometric structure analysis are illustrated by numerous well-chosen examples. The possibilities and limits of the method are discussed in the concluding chapter, with reference to 17
examples .
Random checks have shown that the literature UI: to 1967
has not, after all, been covered completely. This limits to
some extent the use of the book as a reference work, as is
suggested by the text of the dust-cover. The book can be
recommended as an extensive introduction to organic mass
spectrometry and as a good introduction to mass-spectrometric structure analysis. H. F. Grltzmacher [NB 749 IE]
4
Chemie der Eiweisskorper, he Chemistry of Proteins). By
E. Waldschmidt-Leitz a
0 . Kirchmeier. Ferdinand EnkeVerlag, Stuttgart 1968. rd Edit., xi, 258 pp., 8 illustrations, 37 tables. Cloth-bound D M 57.00.
The long established work under review has been extended
by a few chapters to indicate the new developments that have
taken place since the publication of the 2nd edition. The
description of the synthesis and degradation of amino acids
in living organisms deserves especial mention. The reader is
given a good and concise review with ample literature
references.
The book deals primarily with the classical chemistry of
amino acids (coherent treatments of this subject are hard to
find), with the synthesis, preparation, and structure analyses
of peptides, the properties of proteins, and elucidation of their
amino-acid sequences, and finally describes, in brief, a considerable number of proteins. Tn only a few instances would it
have been desirable to discuss new developments in greater
detail,e.g. the denaturation of proteins or the determination of
the tertiary and quaternary structures of proteins as they are
known today. All chapters are carefully supported by literature citations, which enables the student to deepen his understanding by contact with the original work. The book is well
produced and, as usual, the presentation is very clear; in all,
it is a very suitable reference work. H. Fasold [NB 760 I E ~
Atlas of Electron Spin Resonance Spectra. By B. H. J . Bielski
and J . M. Gdbicki. Academic Press Inc., London-New York
1967. 1st EM., xiii, 664 pp., numerous figures and tables,
bound, $ n.00.
A collection of ESR spectra has long been awaited by research
workers in this field. The two authors must be commended
for undertaking this laborious task of collecting spectra from
[2] Cf. P. Brown and C. Djernssi, Angew. Chem. 79, 481 (1967) ;
Angew. Chem. internat. Edit. 6, 477 (1967).
Angew. Chem. internat. Edit. Vol. 7 (1968) / No. 12
the widely scattered data in the published literature. The atlas
contains well over a thousand reproductions of ESR spectra
derived from paramagnetic species in solution, in gases, in
glasses, and in powders - but not, however, in single crystals.
The reproductions are neatly executed and well arranged.
Most of the spectra were published before the end of 1964;
only a few are taken from more recent or from unpublished
work. A certain selectivity limits the completeness of the
work, but increases its reliability. No attempt has been made
to verify the correctness of the data. Apart from the ESR spectra, ancillary information - such as the paramagnetic species,
their preparation, the recording conditions, and coupling
constants - is listed.
While the atlas largely comes up to our expectations, indeed
its usefulness has already been proved several times in the
reviewer’s laboratory, certain shortcomings should not be
overlooked. In the first place, the spectra have not been
selected carefully enough. This is particularly true of the
spectra of radicals that have been recorded under similar
conditions, without essentially differing from each other.
Such spectra could have been omitted, together with the line
diagrams showing the schematic hyperfine structure, which
are largely superfluous. The spin densities calculated from
the measured coupling constants using a somewhat arbitrary
proportionality factor are also unnecessary.
Frequent errors are found in the formulas of the paramagnetic species and in the coupling constants indicated.
For instance three different formulas are used for the three
spectra given for the ally1 radicals @p. 29 and 30):
.
CHz=CH-CH?; CH2=CH-CH2 + CHz-CH=CH*; and
H2C-CH-. CH2. They appear as different species; moreover, in the mesomeric notation the sign should be replaced
by the usual double-headed arrow (++).
The radical cation whose spectrum is reproduced on p. 538
was obtained from 1,3,6,8-tetraazapyrene and not from the
4,5,9,10-tetradeuterio derivative as quoted.
For the radical anion of pyrene the coupling constant of the
two equivalent protons in positions 2 and 7 is erroneously
given twice on p. 533 (aF = -1.09 G and up7 = 1.05 C ) .The
first value is correct, apart from the incorrect negative sign
which cannot be determined from the spectrum given.
The numerical indices of the coupling constants of the p nitrotoluene radical anion (p. 628, top) are meaningless, since
the numbering is missing on the corresponding formula. If the numbers are taken to be those normally used in
chemical nomenclature for p-nitrotoluene they are actually
misleading.
When all is said and done, however, this atlas is a very useful
and commendable aid which every ESR laboratory should
posses. Nevertheless, a critical approach is indicated, and it
would be wise to consult the original literature at !he same
time.
F. Gerson [NB 757 IE]
+
Nuclear Magnetit Resonance Spectra and Chemical Structure.
VoI. I: The Spectral N M R Parameters of Compounds
with Anaryzed Spectra. By W . Briigel. Academic Press,
New York-London / Dr. Dietrich Steinkopff-Verlag.
Darmstadt 1967. 1st Edit., xviii, 235 pp., loose-leaf,
$ 35.00.
In comparison t o the familiar “infra-red Briigel” the present
volume offers not just another spectroscopic method but an
entirely different selection. Whereas the older book was and is - an introduction, this work is almost exclusively a
summary, an ambitious atlas of spectra which no longer
merely lists the spectra themselves, as produced by the
spectrograph, but lists them in an extracted form.
To pass on to the form and content, it might be said that this
is not really a book at all, but rather a file of medium thickness in the A 4 format. The work is divided into an introduction in German and English (7 pp.) tables (212 pp., English
text), a bibliography (520 citations), and a n alphabetical subject index (English, about 2500 entries).
96 1
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