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Book Review Chromatographic EnantioseparationЦ Methods and Applications. (Ellis Horwood Series in Analytical Chemistry). By S. G. Allenmark

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Chromatographic Enantioseparation- Methods and Applications. (Ellis Honvood Series in Analytical Chemistry).
By S. G . Allenmark. Halsted Press, New York/Wiley,
Chichester 1988. 224 pp., hard cover, E 38.50. -ISBN
Research on chiral chromatographic separations is at a
peak at the present time, about 25 years after the feasibility
of direct resolution of chiral phases by modern techniques
was first demonstrated. The variety of systems now known
to display stereoselectivity is considerable, and new developments are constantly emerging. However, the understanding
of the mechanisms involved in chiral recognition lags behind
practical achievements. Also, comparative studies of different procedures recommended for the solution of a certain
problem are scarce.
Under these circumstances, it is not easy to summarize
satisfactorily and comprehensively the state of the art. The
author is to be commended on having attempted to do so,
although, in the opinion of the reviewer, he has only succeeded in part.
The best chapters are those dealing with “Chiral Liquid
Chromatography” and with “Analytical Applications in
Academic Research and Industry”; they represent about half
of the book. This is not surprising, as the direct experience of
the author seems to have been mainly in these areas. Even so,
some interesting recent contributions to chiral LC have not
been included, and in the applications chapter there is n o
mention of geochemical, cosmochemical and archaeometric
analyses, or the study of the configuration of bacterial cell
wall constituents, and of racemization of proteins in living
(including human) beings.
The summary treatment of chiral GC does not do justice
to the importance of this mode of chromatography, nor does
the section on resolution via diastereomers. Such interesting
procedures as the precolumn derivatization of amino acids
by o-phthaldialdehyde plus N-acetyl-L-cysteine (D. W. Aswad, Anal. Biochem., 1984) and the resolution of olefins
through Pt complexes coordinated to chiral ligands (M.
Goldman et al., J Am. Chem. SOC.,1981) are disregarded.
Chiral TLC is not referred to, to say nothing of techniques
related to chromatography, such as droplet counter-current
chromatography and capillary electrophoresis, which have
lately been shown to produce effective enantioseparations.
Angew. Chem. Int. Ed. Engl. 28 (1989) N r . 9
Some topics, such as the use of cyclodextrins as selectors,
would already have to be largely rewritten one year after the
appearance of the book. This is also true, to some extent, of
the brief chapter on “Preparative Scale Enantioseparations”.
The author has not discussed available spectroscopic evidence for some proposed chiral recognition models, nor the
results of any relevant calculations of favored conformations
of selectors likely to be involved in the recognition process.
Such material might perhaps be outside the scope of a book
which is essentially practically orientated. However, certain
of the examples of models of chiral recognition that are
shown would have been more instructive if accompanied by
some additional critical comments. For instance, in Fig. 7.1 5
the nature, and indeed the necessity, of involving a
- CH . . . 0 = C - hydrogen bond in the intermediate
stereoselective complex should have been discussed; and for
the model in Fig. 7.16, possible alternatives to the proposed
C,-C, hydrogen bonded association should have been given
(C,-C, association or intercalation between two selector
Though the text is, in general, lucid, there are instances in
which the original papers have not been accurately quoted or
are better formulated. All statements are, however, referenced and can be readily checked. The legends and annotations of the figures taken from the literature have not always
been adapted to the new text, and the data listed in the tables
are not always complete.
In spite of the above shortcomings, the monograph should
be useful to many readers, particularly as it is at present the
only book covering a relatively wide range of the subject. It
will provide a good idea of the potential of the approach for
researchers in academia, and analysts in industry dealing
with optically active compounds. The copious bibliography
(more than 600 references) will be of great value to the reader.
There are almost no printing errors in the text; the structure given in Fig. 3.3 is drawn incorrectly.
Emanuel Gil-Av [NB 980 IE]
Organic Chemistry Department
Weizmann Institute of Science
Rehovot (Israel)
Theory and Methods of Calculation of Molecular Spectra. By
L. A . Gribov and W J Orville-Thomas. Wiley, Chichester
1988. xxvii, 636 pp., hard cover, E 85.00. -ISBN 0-47191882-2
It is appropriate and welcome that the authors have written a comprehensive book on the theory of molecular spectra
and methods of calculation at the present time. The attractive presentation of this book, the generality of its title, and
its size (more than 600 pages) thus raise high expectations on
the part of potential readers. However, there is a little disappointment on discovering that the book concentrates mainly
on the traditional forms of spectroscopy (IR, Raman, and
vibrational excitations caused during electronic transitions).
The book treats molecular vibrations with great thoroughness, and addresses some interesting aspects and problems.
Thus, for example, the kinetic energy of vibrational motions -including internal rotations - is treated in detail and
illustrated by numerous applications. The expression for the
Verlq@gesell.~chaflmbH, 0-6940 Weinherm, 1989
S 02 5010
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chemistry, analytical, horwood, enantioseparationц, allenmark, book, series, application, method, ellis, chromatography, review
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