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Book Review Comprehensive Biochemistry. Edited by M. Florkin and E. H. Stotz. Vol. 12 Enzymes. General Considerations. Section III Chemistry of Biological Compounds

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Comprehensive Biochemistry. Edited by M. Florkin and E. H.
Stotz. Vol. 12: Enzymes. General Considerations. Section
111: Chemistry of Biological Compounds. Elsevier Publishing Co., Amsterdam-London-New York 1964. 1st edit.,
XI1 + 304 pp., numerous illustrs. and tables, linen
DM 47.50 (about $ 12.00).
The third section of this comprehensive textbook [ I ] contains
discussions of the mechanisms of enzymatic reactions. In
accordance with the overall planning of the book, here too
individual facts are reported only after the regularities
derived from them have been outlined. Because of this
deductive presentation, many facts may be missed by some
readers, but this system has the great advantage that widely
dispersed results are dealt with together. This offers great
benefits, particularly in the discourse on the relationships
between structure and reactivity. The first volume contains
fundamental chapters explaining general aspects of enzymatic
reactions. However, some of the text requires concentrated
study and demands considerable previous knowledge - but
not more than may be reasonably expected for use of a text
book with the aims of the present series. In addition, the
abstract nature of the deductive presentation is comfortably
modified by intermittent sections on methods and their biochemical applications, together with instructive examples.
in the fundamentals of the modes of reaction of enzymes in
The firm foundations of modern enzymology are to be found
aspects such as their stereochemistry (Hirschmann) and their
reactivities, considered from the thermodynamic (WurmserBunerjee) and kinetic (Duwes) viewpoints, which are treated
here with equal elegance. Redox potentials (Wurmser-Banerje e ) and the effects of complex formation with metals on
enzymatic activity (Vallee) are important topics which are
given individual treatment. The connections between enzyme
structure and function are particularly well investigated for
ribonuclease and chymotrypsin and are reviewed in exemplary fashion by Hirs. His chapter simultaneously illustrates
the methods of acquiring and interpreting kinetic data,
which were discussed on a general basis in the preceding
sections. This coordination is particularly fortunate.Although
we are still far from knowing any common denominator for
enzymatic functions, a few general theories of enzymatic
catalysis can be conceived (Wilson); these include the
hypothesis of induced fit, the formation of a reactive transition state in the enzyme-substrate complex (Reiner), and
the course of reactions in enzyme-bonded steps. All the
sections give a thorough, stimulating interpretation on a high
standard and by clever overlapping cover the entirety of this
vast field. Both the authors and editors have again done a
good job and developed the tools for following the modern
developments in molecular and dynamic biochemistry.
L. Juenicke
[ I ] Cf. Angew. Chem. 76, 868 (1964).
[NB 381/239 IE]
Subject I n d e x
for the conference report ‘‘General Meeting of the German Chemical Society” on p. 966
of this issue. The numbers in this index refer to the numbers heading the abstracts.
ACENES, A New Semiquantitative Calculation of the Delocalisation Energy
in Benzene and in the
ACETONITRILES, Sodium -, Prepn.
and Reacns. 54
Acyloxynitrosoalkanes, Geminal
their Dimers 53
p-Adamantonecarboxylic Acids, Synth. of
the Two Stereoisomeric
Adsorption, Effects in Polarography Attriof Reactants
butable to the Specific
Alkaloids, Biosynth. of Lupine
Alkylenediphosphines, Prepn. and Prop59
erties of Diprim.
Americium, Chelation of Neptunium, Plutonium, and
by Derivs. of 8-Hydroxyquinoline 17
Amides, Sepn. of Rotational Isomers of
-, Thioamides, and Nitrosamides 60
-, Synth. of Cycloamides and Cyclopeptides with Medium-Sized Rings 72
from CO
Amines, Synth. of Aliphatic
Steam, and NH3 48
Amino Acid Analysis, Stable Nihydrin
Reagent for Automatic
Amino-p-benzoquinones, Interpretation
of the Spectra of
Amylases, New Enzymatic Baking Agents
in Iron
Argon, Determination of K and
Meteorites by Neutron Activation Analysis 64
Arsines, Synth. and Properties of some
New Phenyltinarsines, Stibines, and Bismuthines 81
Aryl Esters, Prepn. of
A n g e w . Clzem. internut. Edit. / Vcf. 4 (1968)
Azides, Stability of Boron
-, Chemistry of Silyl
Azines, Conversion of Diaziridines into
Azodiphosphoric Acid, Reacns. at the
N=N Double Bond of
BAKING AGENTS, New Enzymatic
Barbiturates, Infrared-Spectroscopic Investigation of
Benzene, New Photochem. Reacn. of
and Some of Its Homologues 49
-, An Accurate and Simple Calculation
of the C-C Distance in
-, A New Semiquantitative Calculation
of the Delocalisation Energy i n
in the Acenes 42b
Benzene Oxide, NMR-Spectroscopic Studies of the Equilbrium and Kinetics of
---Oxepin Conversions 30
Benzoquinones, Interpretation of the
Spectra of Monoamino-p15
Binders, Interaction of Pigments and
Solid Paint Films 23
Bismuthines, Synth. and Properties of New
Phenyltinarsines, Stibines, and
Boron Azides, Stability of
Boron(II1) Oxide, Ternary Compds. and
Solid Solutions in the System Calcium
Oxide/Phosphorus(V) Oxide/
CALCIUM OXIDE, Ternary Compds.
and Solid Solutions in the System -/
Phosphorus(V) Oxide/Boron(III) Oxide
No. I 1
Carbenes, Attempted Prepn. of -, N i trenes, and Sulfenes 46
-, New Method of Generating
Carbon, Reacns. of “Hot”
Atoms in
Nitrogen/Alkaiie Systems 1
Carbonato Compds. of Praseodymium(1V)
and Terbium(1V) 69
Carbonium Salts, Rearr. of Homoallylic
Carbonyls, Mechanism of the Reaction of
Metal Hexacarbonyls with n- and xDonors 90
Chelation of Neptunium, Plutonium, and
Americium by Derivs. of 8-Hydroxyquinoline 17
Chlordane, Synthesis and Structure of
Insecticidal Polychlorotetrahydromethanoindanes 12
Chloromethoxyacetate, Syntheses with
Chromomycin, Mode of Action of the
Cobalt, Exchange Reacns. in Solid -, Rh,
and Ir Complexes Initiated Thermally
and by the80m Br Nuclear Transition 79
-, Stereospecific Retention in Nuclear
Reactions on cis/trans-Isomeric
Complexes 95
Coronaphenes, a New Group of Cyclic
Hydrocarbons 43
Crystal Surface, Influence of the Crystal
Field on the Acidity of Protons in the
Crystal and on the
Cyanic Esters, Addn. Reacns. of
Cyanosilanes, Prepn. of
Cycloadditions, Optical Induction in Six75
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