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Book Review Die Nucleinsuren (Nucleic Acids). By E. Harbers in collaboration with G. E. Domagk and Werner Mller. Eine einfuhrende Darstellung ihrer Biochemie und Funktionen (An Introductory Description of their Biochemistry and Functions)

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An improved apparatus for continuous electrophoresis without
a support has been developed by K . ffannig. In contrast to
previous equipment, the electrophoresis cell (48 x 48 cm2;
0.5 mrn layer thickness) is mounted vertically and has a
uniform flow of buffer normal to the electric field, achieved by
introducing the buffer through six inlets at the upper edge and
removing it from fifty leads at the lower edge. The solution to
be separated can be fed in continuously to the buffer stream
close to the upper edge a t one of several points. Previously.,
the problem of non-uniform cooling prevented vertical arrangement of the electrophoresis cell, for the slightest
temperature gradients caused disturbances of the laminar
flow of buffer owing to convection currents. This difficulty
has been overcome by covering the rear wall of the cell uniformly. with Peltier batteries. About 2500 v at about 160 mA
is used. - The apparatus can separate protein mixtures continuously even when the molecules in the mixture differ by
only one charge unit. Because of the vertical arrangement,
the range of application of the instrument could be extended
even to particles which in horizontal cells sediment out on
the lower plate and upset the separation. Clean separations
of cellular constituents (e.g. chloroplasts, mitochondria, cell
nuclei, and nuclear fragments from spinach leaves) and even
of intact cells (e.g. human and rabbit erythrocytes or Walker
ascites tumor cells and leucocytes) were achieved with the
new instrument. The fractions exhibited excellent homogeneity
in the electron miscroscope. Even virus mutants can be
separated. / Hoppe-Seylers Z. physiol. Chem. 338, 211, 278
(1964) / -HO.
[Rd 2661475 IE]
Ionenaustausch-Chromatographie (Ion-Exchange Chromatography). By K . Dorfner. Akademie-Verlag, Berlin 1963.
236 pp., 149 illustrs., 14 tables, linen D M
1st edit., X
32.50 (about $ 8.25).
The author, a former coworker of B. Sansoni in Marburg
(Germany), has recorded his knowledge and ‘ experience in
the field of ion exchangers in two books; in the present
volume he presents a review of ion-exchange chromatography,
starting from elementary fundamentals that can be understood by all. It is simultaneously the second volume in the
series “Ionenaustauscher in Einzeldarstellungen” (Monographs on Ion Exchangers) edited by Griessbach. The book
has two main divisions: methods of ion-exchange chromatography (fundamentals of chromatography, ion-exchange
chromatography, types of ion exchangers, apparatus), and
their applications in inorganic and organic chemistry (including natural products). The ordering principles applied
are the groups of the periodic system of the elements and the
compound classes in organic chemistry.
The text is augmented by 149 figures and 14 tables, and
946 literature references are given, covering publications up
to about 1960. Within the aims of the book, all the essentials
are well dealt with. The subject matter is well arranged, and
the style of the writing is fluent, so.that the book well fulfils
its purpose of providing an introduction t o the subject and
serving as a source of information.
E. BIasius
[NB 3771235 IE]
Die Nucleinsauren (Nucleic Acids). By E. Harbers in collaboration with G . E. Domagk and Werner MiiIIer. Eine einfuhrende Darstellung ihrer Biochemie und Funktionen
(An Introductory Description of their Biochemistry and
Functions). Georg Thieme Verlag, Stuttgart 1964. 1st edit.,
XI1 + 303 pp., 155 figs., 20 tables, linen D M 68.- (about
$ 17.25).
This monograph on nucleic acids does not merely bring a
discussion of t h e fundamental facts in this field; the breadth
and depth of the data given are sufficient t o satisfy even
high demands - in their didactic nature as well. The book
is intended for all scientists with a n interest in biology and
to medical researchers occupied with biochemical problems.
The chemistry of nucleic acids and their constituents is given
a n exemplary historical and theoretical treatment by W . Miilh,
together with many practical tips for laboratory work.
The biosynthesis of purines, pyrimidines, pentoses, and
nucleotides is described by G. E. Domagk. There follow
chapters o n the metabolism of D N A and RNA, the transfer
of genetic information from cell to cell, the induction of
mutations, nuclei acids in tumor cells, interference o f drugs in
nucleic acid metabolism, and the effects of radiation on
nucleic acids.
The newcomer to this field will welcome the appendix, which
records some classical methods for metabolic studies and for
preparative, analytical, and physico-chemical experimentation with nucleic acids. An unusually large list of sources
of information and, in contrast, a very meagre subject index
close the book, which is highly recommendable in view of
its copious content. It is to be hoped that a more reasonable
price will make a second edition available to a broader
H . Maibhaei
[NB 3831241 IE]
Essays on Coordination Chemistry. Dedicated to Gerold
Schwarzenbach on his 60th Birthday, 15 March, 1964.
Edited by W . Schneider, G . Anderegg, and R . Gut. Experientia Supplementum IX, Birkhauser Verlag, Basel-Stuttgart 1964. 1st Edit., 305 pp., numerous figures and tables,
linen, D M 48.- (about $12.00).
Cerold Schwarzenbach is one of the most prominent scientists
and responsible for significant advances in the modern development of complex chemistry. It is therefore only fitting that
the scientific world should mark the special occasion of his
sixtieth birthday, and all with an interest in coordination
chemistry will certainly appreciate.the fact that this was done
.in the form of ,an anthology of essays written by outstanding
workers in this field.
Most of the 23 articles dedicated to Schwarzenbach are directly related in some way to his own work. This can be said
in particular of the first contribution by W . Schneider, which
is an appraisal of Schwarzenbach’s research in the field of organic chemistry, if the compounds investigated are considered.
Actually, the problems studied were more of a physical-chemical nature, as for example the protogenic properties of organic acids in dependence upon the nature of the substituents.
A list of papers published by Schwarzenbach up to 1963 is
appended to this article.
The main credit due to Schwarzenbach is for his work on the
chemistry of complexes in aqueous solutions. One of the most
importar@ results of this work is complexometry, which is
now known to every chemist as an invaluable analjtical tool.
It is therefore not unwarranted that seven essays deal with
the coordination chemistry of aqueous solutions, e. g. L. G.
Sillen’s article (Thoughts during a Walk in Lappland), the
value of which lies in its intimate personal note. Naturally
J . Bjerrnm is not missing among the authors. His essay deals
with the behavior of Hgza towards ethylene diamine in contrast to that of Ago and frequently touches closely upon
Schwarzenbach’s own work. The solid state also comes under
discussion : W. Feitknecht describes the composition and
structure of the hydroxide salts of bivalent metals formed
during complex-chemical reactions.
Other articles in the book are important for the theoretical
treatment of questions in coordination chemistry (problems
Angew. Chem. internat. Edit.
VoI. 4 (1965)
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