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Book Review Essays on Coordination Chemistry. Dedicated to Gerold Schwarzenbach on his 60th Birthday 15 March 1964. Edited by W.Schneider G. Anderegg and R

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An improved apparatus for continuous electrophoresis without
a support has been developed by K . ffannig. In contrast to
previous equipment, the electrophoresis cell (48 x 48 cm2;
0.5 mrn layer thickness) is mounted vertically and has a
uniform flow of buffer normal to the electric field, achieved by
introducing the buffer through six inlets at the upper edge and
removing it from fifty leads at the lower edge. The solution to
be separated can be fed in continuously to the buffer stream
close to the upper edge a t one of several points. Previously.,
the problem of non-uniform cooling prevented vertical arrangement of the electrophoresis cell, for the slightest
temperature gradients caused disturbances of the laminar
flow of buffer owing to convection currents. This difficulty
has been overcome by covering the rear wall of the cell uniformly. with Peltier batteries. About 2500 v at about 160 mA
is used. - The apparatus can separate protein mixtures continuously even when the molecules in the mixture differ by
only one charge unit. Because of the vertical arrangement,
the range of application of the instrument could be extended
even to particles which in horizontal cells sediment out on
the lower plate and upset the separation. Clean separations
of cellular constituents (e.g. chloroplasts, mitochondria, cell
nuclei, and nuclear fragments from spinach leaves) and even
of intact cells (e.g. human and rabbit erythrocytes or Walker
ascites tumor cells and leucocytes) were achieved with the
new instrument. The fractions exhibited excellent homogeneity
in the electron miscroscope. Even virus mutants can be
separated. / Hoppe-Seylers Z. physiol. Chem. 338, 211, 278
(1964) / -HO.
[Rd 2661475 IE]
Ionenaustausch-Chromatographie (Ion-Exchange Chromatography). By K . Dorfner. Akademie-Verlag, Berlin 1963.
236 pp., 149 illustrs., 14 tables, linen D M
1st edit., X
32.50 (about $ 8.25).
The author, a former coworker of B. Sansoni in Marburg
(Germany), has recorded his knowledge and ‘ experience in
the field of ion exchangers in two books; in the present
volume he presents a review of ion-exchange chromatography,
starting from elementary fundamentals that can be understood by all. It is simultaneously the second volume in the
series “Ionenaustauscher in Einzeldarstellungen” (Monographs on Ion Exchangers) edited by Griessbach. The book
has two main divisions: methods of ion-exchange chromatography (fundamentals of chromatography, ion-exchange
chromatography, types of ion exchangers, apparatus), and
their applications in inorganic and organic chemistry (including natural products). The ordering principles applied
are the groups of the periodic system of the elements and the
compound classes in organic chemistry.
The text is augmented by 149 figures and 14 tables, and
946 literature references are given, covering publications up
to about 1960. Within the aims of the book, all the essentials
are well dealt with. The subject matter is well arranged, and
the style of the writing is fluent, so.that the book well fulfils
its purpose of providing an introduction t o the subject and
serving as a source of information.
E. BIasius
[NB 3771235 IE]
Die Nucleinsauren (Nucleic Acids). By E. Harbers in collaboration with G . E. Domagk and Werner MiiIIer. Eine einfuhrende Darstellung ihrer Biochemie und Funktionen
(An Introductory Description of their Biochemistry and
Functions). Georg Thieme Verlag, Stuttgart 1964. 1st edit.,
XI1 + 303 pp., 155 figs., 20 tables, linen D M 68.- (about
$ 17.25).
This monograph on nucleic acids does not merely bring a
discussion of t h e fundamental facts in this field; the breadth
and depth of the data given are sufficient t o satisfy even
high demands - in their didactic nature as well. The book
is intended for all scientists with a n interest in biology and
to medical researchers occupied with biochemical problems.
The chemistry of nucleic acids and their constituents is given
a n exemplary historical and theoretical treatment by W . Miilh,
together with many practical tips for laboratory work.
The biosynthesis of purines, pyrimidines, pentoses, and
nucleotides is described by G. E. Domagk. There follow
chapters o n the metabolism of D N A and RNA, the transfer
of genetic information from cell to cell, the induction of
mutations, nuclei acids in tumor cells, interference o f drugs in
nucleic acid metabolism, and the effects of radiation on
nucleic acids.
The newcomer to this field will welcome the appendix, which
records some classical methods for metabolic studies and for
preparative, analytical, and physico-chemical experimentation with nucleic acids. An unusually large list of sources
of information and, in contrast, a very meagre subject index
close the book, which is highly recommendable in view of
its copious content. It is to be hoped that a more reasonable
price will make a second edition available to a broader
H . Maibhaei
[NB 3831241 IE]
Essays on Coordination Chemistry. Dedicated to Gerold
Schwarzenbach on his 60th Birthday, 15 March, 1964.
Edited by W . Schneider, G . Anderegg, and R . Gut. Experientia Supplementum IX, Birkhauser Verlag, Basel-Stuttgart 1964. 1st Edit., 305 pp., numerous figures and tables,
linen, D M 48.- (about $12.00).
Cerold Schwarzenbach is one of the most prominent scientists
and responsible for significant advances in the modern development of complex chemistry. It is therefore only fitting that
the scientific world should mark the special occasion of his
sixtieth birthday, and all with an interest in coordination
chemistry will certainly appreciate.the fact that this was done
.in the form of ,an anthology of essays written by outstanding
workers in this field.
Most of the 23 articles dedicated to Schwarzenbach are directly related in some way to his own work. This can be said
in particular of the first contribution by W . Schneider, which
is an appraisal of Schwarzenbach’s research in the field of organic chemistry, if the compounds investigated are considered.
Actually, the problems studied were more of a physical-chemical nature, as for example the protogenic properties of organic acids in dependence upon the nature of the substituents.
A list of papers published by Schwarzenbach up to 1963 is
appended to this article.
The main credit due to Schwarzenbach is for his work on the
chemistry of complexes in aqueous solutions. One of the most
importar@ results of this work is complexometry, which is
now known to every chemist as an invaluable analjtical tool.
It is therefore not unwarranted that seven essays deal with
the coordination chemistry of aqueous solutions, e. g. L. G.
Sillen’s article (Thoughts during a Walk in Lappland), the
value of which lies in its intimate personal note. Naturally
J . Bjerrnm is not missing among the authors. His essay deals
with the behavior of Hgza towards ethylene diamine in contrast to that of Ago and frequently touches closely upon
Schwarzenbach’s own work. The solid state also comes under
discussion : W. Feitknecht describes the composition and
structure of the hydroxide salts of bivalent metals formed
during complex-chemical reactions.
Other articles in the book are important for the theoretical
treatment of questions in coordination chemistry (problems
Angew. Chem. internat. Edit.
VoI. 4 (1965)
concerning the nature of the bonding, and stability problems,
particularly in connection with coordinatioh). These include,
for example “Die Bedeutung quantenmechanischer Modelle
fur die Chemie” (the importance of quantum-mechanical
models in chemistry) by H . Hartmann, “Inorganic Chromophores” by C. K. Jiirgensen, “The Stabilisation, Stereochemistry, and Reactivity of Five-coordinated Compounds” by
R . S. Nyholm and M. L. Tobe, and the “Structure and Bonding in Transition Metal Complexes of Some Unsaturated
Ligands” by R . Masea and G . Wilkensen.
0 . Schrnifz-DuMonf [NB 333!191 IE]
Chemotaxonomie der Pffanzen (Chemical Taxonomy of
Plants). By R . Hegnauer. Vol. 3 . Dicotyledoneae. Part I :
Acanthaceak-Cyrillaceae. Chemical Series, Vol. 18. Birkhauser Verlag, Basel-Stuttgart 1964. 1st edit., 744 pp.,
14 figs., 17 tables, clothbound D M 123.-‘(about S 31.50).
When conservative, stdndards afe applied, dicotyledons are
divided into about 270 fahilies; 79 of these are discussed in
the present volume [I]. The book therefore d g l s with some
3500 genera comprising about 45000 species. These include
some very large families or genera ‘that are important in
other connections, including the Compositae, the Ap3cynaceae, Cruciferae, e f c . Chemists interested in plant
products will therefore want to inspect this volume .with
careful attention.
The organization of the material within each family discussed
corresponds to that used in earlier volumes: first come a
short botanical description and the systematic classification,
then a summary of important morphological and chemical
characteristics, the latter frequently being subdivided according to substance classes, and finally literature references and
concluding remarks which contain the essence of the taxonomic features of the plants. Mostly the main chemical
constituents of the plants are critically appraised here
whenever they appear very frequently in a certain family
and are highly typical for it in contrast to other families. In
this way, sometimes clear-cut decisions can be made in favor
of one of another known system of plants. The dangers of
taxonomic classifications based on single substances are
emphasized. There are of course many examples of individual chemical compounds that occur sporadically in
plants which are definitely not interrelated, e . g . lysergic
acid derivatives in certain species of Convulvulaceae or Ascomycetes. The reader again observes that extremely widespread and thoroughly investigated materials such as
the carotenoids contribute but little to the solution of
taxonomic problems.
In contrast to the volumes that have already appeared, on
account of the immense amodnt of material dealt with,
the literature and individual compounds have not been
comprehensively reviewed. Nonetheless, a great deal of
otherwise difficultly accessible literature has been evaluated.
The organic chemist will be surprised to find that the formulae shown have again been drawn with complete disregard
of the stereochemistry of the compounds concerned. The
author indicates many deficiencies in phytochemical research
and may thus provide incentives for new research wprk.
Misprints and factual errors are few; the quality of the paper,
print and binding are as usual excellent.
C . H . Eugster
[NB 4091266 I € ]
The Monosaccharides. By J. Starze‘k, M . Cerny, J. Kocourek,
and J. Pacak. Academic Press, New York-London, and
Publishing House of the Czechoslovakian Academy of
Sciences, Prague, 1963. 1st edit., 1006 pp., 40 figs., 64
tables, linen $ 32.-.
An English translation is now available of the book “Monosacharidy” by J. Stanlk et al. The appearance of this translation is to be welcomed, for now this monograph o n a well
111 Forreviewsof\lols. 1 and2seeAngew. Chem. 76, 312(39643;
Angew. Chem. internat. Edit. 3,452 (1964).
Angew. Chem. internat. Edit. 1 VoI. 4 (1965)
1 No. 8
defined section of carbohydrate chemistry is available to a
much larger public. The English edition is not merely a
s:mple translation of the first Czechoslovakian edition; the
contents have been considerably reshuffled and extended,
producing a great improvement in the book. Moreover, work
published up until about 1962 has now also been included.
In the monograph, the most diverse derivatives of this class
of substances are described, and their manifold reactions are
discussed in detail, often exhaustively. l’he specialist in this
field will therefore gladly take first recourse to this work for
rapid orientation. The book is also aimed at satisfying the
demands of other chemists associated in part with carbohydrate chemistry in close connection. with their own investigations, e . g . biochemisrs and iiidustrial chemists, for
here they find a well arrgnged wealth of information. Numerous tablesinterspersed between the text give rapid informa$ion on the derivatives of the monosaccharides prepared to
date. The l-ist of references given has been compiled with
especial care. Each chapter contains references t o large review
articles to facilitate the search for particular details or for
original publications. The literature from relatively obscure
journals has also been almost completely scanned,’and even
the specialist may find many a reference he has previously
overlooked. ,
The book contains a short but fully satisfactory chapter for
superficial information on tke biochemical syntheses and
conversions of sugars in biological systems. Further details
on this rapidly advancing subject can be found in scientific
journals in any case. However, a more extensive treatment of
modern investigations into stereochemical topics and reaction
mechanisms would have been preferable. Aspects such as
conformational analysis, the mechanisms of substitution
reactions and the associated questions of stereochemistry and
neighboring-group participation, and applications of N M R
spectroscopy are at the focus of attention in the carbohydrate
field a t present and will be studied more intensely in future.
These suggestions might be considered for future editions.
The present volume is thus a n important source of information for a large circle of users and deserves a place in every
chemical library. A second volume on“The Oligosaccharides”
has already been announced which ought to provide a
supplement to the present book.
H . Paulsen
[NB 3701228 lE]
The Proteins. Composition, Structure, and Function. Vol. 1.
Edited by H . Neurufh. Academic Press, NewYork-London
1963. 2nd edit., XI11 f 665 pp., numerous illustrs. and
tables, linen S 22.-.
The following topics are dealt with in six chapters: l.“AminoAcid Analysis of Peptides and Proteins” ( A . Light and E. L.
Smith) with an appendix on “Amino-Acid Analysis of
Certain Proteins” by G . R. Tristrum and R. H . Smith;
2. “Synthesis and Function of Peptides of Biological Interest”
(K. Hofmann and P. G . Kafsoyannis); 3. “Chemical Aspects
of Protein Synthesis” (J. S. Fruton); 4 . “Concepts and
Experimental Approaches in the Determination of the
Primary Structure of Proteins” ( R . E. Canfield and C . B.
Anfinson); 5 . “Intramolecular Bonds in Proteins, I. The
Role of Sulfur in Proteins” ( R . Cecil); 6. “11. Non-covalent
Bonds” (H. A. Scheragu).
The survey shows that the subjects dealt with are arranged
less systematically than in the first edition, being aimed more
directly at individual acute problems. The subtitle of the
book reveals the reason for this selection, namely the coordination of chemical structure and biological function, as is
prominently apparent,, particularly in the second chapter.
Following a discussion of the modern methods of peptide
synthesis, their application to the preparation of hypophyseal
hormone, angiotensin, bradykinin, and kallidin peptides is
described, and the structure-function relationships are
illuminated, particularly for the oxytocin-vasopressin group
and for the melanophore-stimulating systems. The first
chapter is also highly instructive, but a little more emphasis
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