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Book Review Foreign Compound Metabolism in Mammals. Vol. 1. Specialist Periodical Reports

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haloalkyl residues, and/or nitro residues; R‘ and RZ
together with the nitrogen atom form a heterocycle. [DOS
1693 036; Laboratories Laroche, Navarron]
[PR 19 IE -K]
ketones (2) in the presence of an acid-binding agent. The
compounds ( 3 a ) and ( 3 b ) can be obtained by reaction of
( I ) with the alkenes ( 4 ) in the presence of a base or by
reaction of ( I ) with formaldehyde and the ketones ( 5 ) under
the conditions of a Mannich reaction.
The contraceptivereliability of the &pill can be imprwed
by the daily administration of a combination of a progestagen and a progestin (ratio 10-3O:l) instead of a
gestagen. 17a-Ethynyltestosterone derivatives or 1%nortestosterone derivatives are regarded as progestins, and
progesterone or retroprogesterone derivatives as progestagens. The dose of each component is lower than the
dose of the same component that is required for reliable
contraception when used alone as a minipill. [DOS
2 146 239 ; CIBA-Geigy AG, Basel]
[PR 27 IE -N]
1,3,4,9b-Tetrahydro-2H-indeno[l,Zc]pyridi (3)and their
acid adducts are characterized by a pronounced inhibitory
effect on open aggression in doses such that general depression of the central regulations is not yet detectable.
They can be used for the treatment of hereditary or congenital disturbances of personality and for the prevention
and treatment of mental illnesses. The compounds ( 3 ) can
be obtained by reaction of the indenopyridines ( I ) with
R’
X
=
=
R4 =
lower alkyl, cycloalkyl, (substituted) aryl; A = alkylene (C ,-C4)
acid residue of a reactive ester; R2,R3 = H, alkyl (C,,C,)
lower rert-alkyl, (substituted) aryl.
[DOS 2046298; Sandoz AG, Basel]
[PR 26 IE -N]
BOOK R E V I E W S
Biochemisches Praktikm (Manual of Practical Biochemistry). By S . Heilenz, W . Hofner, and K . H . Neurnann. Bibliographisches Institut, Mannheim 1970. 1st
Edit., 239 pp., 27 figures, bound, D M 8.90.
This laboratory course manual presents a collection of
classical and modem methods of quantitative analysis for
students of agricultural, forestry, and food sciences. It is
intended to be covered in a two-semester course of 5 hours
per week, and to provide students with a grasp of the
possibilities for dealing quantitatively with their specific
problems. The selection of methods is therefore almost
entirely confined to the narrow field of fertilizer and plant
ash analysis.
The first few sections, which are clearly based on direct
practical experience, provide very exact and detailed
introductions to the methods of gravimetric and volumetric
analysis, flame photometry, and colorimetry. A few
practical exercises are set in each case, but these are sometimes, as in the case of the colorimetric determination of
Cu, highly colored by the circumstances of the particular
application, or else the authors, as in the discussion of the
further possibilities of spark spectroscopy or atomic
absorption spectroscopy, have allowed their enthusiasm to
carry them far beyond the bounds of a course manual.
The presentation of the theoretical principles is readily
comprehensible.
The chromatographic experiments are weak, the methods
that are most important at present, such as gas chromatogAngew. Chem. internal. Edrt.
Vol. I 1 (1972) 1 No. 9
raphy, merely being reported. The radiochemical experiments are poorest of all. One receives the impression that
these later parts of the book, which are treated unfeelingly,
are too short, because of lack either of material or of time,
and that they have been included mainly for show, though
they constitute the most “biochemical” material of the
entire course, since such an introduction becomes a handbook of practical biochemistry only if the biological aspect
is not ignored. It is time for biochemists to resist the widespread misuse of their name. Where in this course is anything said about the living or surviving object? Only in the
very briefly mentioned uptake of 3zP and 59Fe in plant
material. However, once the biochemist has overcome this
disappointment and accepted the entire book as a slightly
modified manual of practical analysis, it is a well-intentioned and well-produced book, from which the student
and even the course supervisor can learn a great deal.
L. Jaenicke [NB 62 IE]
Foreign Compound Metabolism in Mammals. Vol. 1 .
Specialist Periodical Reports. Published by The Chemical
Society, London, 1970. 1st Edit., iii, 455 pp., numerous
figures and tables, bound E 11.OO.
The question of the metabolic fate of drugs, food additives,
and pesticides has always been raised by biochemists and
pharmacologists, but is also increasingly stirring the
public conscience, following recent incidents that have
shown the serious consequences, both for the individual
857
and for thecommunity, that can result from the indiscriminate recommendation and use of such substances.
more detailed; moreover, familiarization with the field
would have been facilitated by a list of further reading.
Toxicologists and clinical pharmacologists have the responsible task of investigating not only the mode of action
but also the side reactions and breakdown of chemicals
before they are placed on the market, and of pointing out
possible dangers. In this work they make use of modern
biochemical procedures and analytical methods, as well as
their knowledge of biochemistry as a fundamental science.
The information that has been acquired and collected here
frequently allows a priori prediction of possible harmful
effects and carcinogenic action, whether direct or uia
breakdown and transformation products. Nevertheless,
there have been many surprises, which show the need for
constant watchfulness, particularly since it is too easy to
forget that extrapolations from one species of animal to
another, or even to man, are unreliable, and that differences
due to sex and condition exist even within the same species.
Knut Buchmann [NB 63 IE]
The present volume, which is the first of a series of progress reports on the metabolism of foreign compounds in
mammals, deals with the absorption, distribution, and
excretion of drugs, the kinetics of these processes, and the
experimental labeling methods for the investigation of
these pharmacodynamically important problems, as well
as the transformations and transformation pathways of
drugs in the mammalian organism as a function of age,
sex, and state of development. It presents a modern and
extremely topical survey of the pharmacological and other
relevant literature of the 1960’s. The publications, which
were often widely scattered, have been collected, sorted,
and above all presented critically and understandably
from the chemist’s point of view by several authors. The
report does not mention the latest techniques of gas
chromatography and mass spectrometry, which promise,
individually and in combination, to become a n important
aid in the statics and dynamics of drug metabolism, o r the
bioactivation of drugs and inhibitors as an essential factor
in their biological and therapeutic activity; however, the
material presented is very carefully balanced in itself.
This work will be extremely useful to all clinical pharmacologists, toxicologists, and biochemists, as well as to
interested chemists, as an up-to-date reference work. It
also provides interesting reading, and goes into the principles and the development of the problems, so that it may
provide the biologically less experienced chemist with new
insights.
L. Jaenicke [NB 61 IE]
Radiochemie (Radiochemistry). By W. Schdze, Walter de
Gruyter & Co., Berlin 1971. 1st Edit., 157 pp., 33 figures,
stitched DM 7.80.
The book provides an introduction to the types of nuclear
radiation, the interaction of radiation with matter, the
measurement of radiation, working rules, and working
methods of radiochemistry, as well as the preparation of
radionuclides. Most radiochemical problems and some of
the problems of nuclear chemistry are presented in a readily
understandable fashion. The strength of the book lies in
the concise manner in which the basic principles are presented. The text is well supported by tables and figures.
The book is particularly suitable for chemistry students
desiring an introduction to the field of radiochemistry, but
will also be extremely useful to other scientists who wish to
familiarize themselves with the fundamentals of radiochemistry. The subject index could have been somewhat
858
Chemical Energetics. By N . J . Selley. Edward Arnold Ltd.,
London 1971. 1st Edit., ix, 209 pp.. numerous tables,
bound 5 3.20.
The author of this little book attempts to give an
introduction to chemical thermodynamics, e. g . within the
scope of a first course with exercises on general chemistry.
The book contains many exercises (with solutions at
the end of the book), fully worked examples, and instructions for practicaI experiments, as well as a (rather skimpy)
subject index, a table of four-figure logarithms, and tables
of atomic weights, bond energies, redox potentials, eic.
It is therefore a textbook and a laboratory manual all
in one
The book is practically free from printing errors and is
well laid out. UnfortunateIy, it has little pedagogical
value and the writing is sloppy in places. It may be pardonable, when symbols like i v e (for “positive”) or RMS
(for “root mean square”) are not explained anywhere
in the book, since these are probably familiar to the
English readers for whom the book was written. However,
inadequacies stand out when definitions become ambiguous
(e.g. on p. 9, 1 eV = 1.6 x 10- l9 J is followed by 1 eV/mol
=96487 Jmol-’) or when concepts are obscured (as e.g.
van der Waals forces on p. 49). It almost seems to be a
principle of the author to use a new concept first and to
explain it later (e.g. the relation AG = - 2.3 RT log K on
p. 31 or the salt bridge on p. 36). Also awkward is the
introduction of the entropy concept (AG = A H - T.soniething), and inept wording is too common to be overlooked
( e . g . on p- 40 “. . .the sign of A S cannot be predicted, but
is probably small. . .” or on p. 69 “As the efficiency of the
harnessing of the work of reaction is made more efficient,
the net gain of entropy is reduced”, etc.). And that the
reaction rate be proportional to e-l’T (p. 85) or that
the kineric energy be quantized (p. 59) can at best be
described as misleading.
At most, therefore, the book has some value as a collection
of exercises. However, in view of the outstanding books
on chemical thermodynamics that already exist in German
and in English, it cannot really be recommended to anyone.
Giinther c. Biinau
[NB 64 IE]
Organic Photochemical Syntheses. Vol. I. By R.Sriniuasan
and T. D.Roberts. Wiley-Interscience, New YorkLondon 1971. 1st Edit., x, 108 pp., numerous figures
and tables, bound d: 4.75.
The present volume, which is the first of a planned series,
corresponds in style and layout to the well-tried pattern
of “Organic Syntheses”. A brief introduction to photochemical techniques, with mention of a number of safety
precautions (17 pages), which is not intended to replace
the study of more comprehensive systematic monographs
(e.g. A . Schonberg, G. 0.Schenck, and 0. A . Neumiiller
Preparative Organic Photochemistry. Springer, Berlin
1968), is followed in varied succession by 39 detailed procedures from 28 research groups, nearly all of which have
been independentIy checked. This provides even the nonphotochemist with easy access to 20 products containing
four-membered rings and five products with threeAngew. Chem. internat. Edit. / Vol. 11 (1972) / NO. 9
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