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Book Review Fortschritte der Arzneimittelforschung. Progress in Drug Research. Progrs des recherches pharmaceutiques Vol. 9. Edited by E

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chaptcrs are devoted to amino acids, peptides and proteins,
carbohydrates and their derivatives, sterines, and steroids.
T!ie;e follows a discussion of metabolic products, the determination of which is important in the study of biochemical
processes or for diagnostic purposes, e.g. for the testing of
organ functions or for the determination of pathological
changes in function.
The majority of such problems involve the determination of
compounds in organic materials of plant or animal origin.
Consequently, if the iso!ation and purification operations are
not to be too expcmive, the specificity of the method plays an
importdncc role. The critica! notes in this connection, which
also deal with sensitivity, reproducit ivty, and possible errors
of e a c t individual method, therefore will be particularly
valuable to the user. Furthermore, a3 rn the previous volumes,
an Bttempt is again made together in the course of the color
reactions on which a determination is based. The literature
is systematically covered up to the end of 1962, and “a
number of important studies published in 1963 are also
taken into account”.
This volume of the manual again gives a n impression of
havin? been carefully compiled. The volume will be very
welcome in all laboratories in which such investigations are
cairied out, since, by obviating the need for laborious
literature searches, it greatly facilitates the choice of a
method.
H. Eohme
[NB 554 IE]
[l] Cf. Angew. Chem. 75, 390 (1963).
121 Cf. Angew. Chem. 76,700 (1964).
Fortschritte der Arzneimittelforschung. Progress in Drug
Research. Progres des recherches pharmaceutiques, Vol. 9.
Edited by E. Jrrcker. Birkhauser Veda& Basel-Stuttgart
1966. 1st Edit., 414 pp., numerous ngures and tables, cloth
D M 88.--.
The 9th volume of the series[*] again presents detailed
reviews of important topics. H. J. Melching and C . Streffer
report (118 pp.) on work on “The influence of drugs on
the sensitivity of mammals to radiation”. After a short
introductory passage on the biochemistry of radiation
damage, the various groups of active substances are critically
discussed and a brief description of their action mechanism
closes the section. A discussion of “Structural considerations
o n psychopharmaceutics: attempted correlation of chemical
constitution and clinical effect“ is presented by K. Stach and
W. Piildingrr (61 pp.). The pharmacology and clinical use
of the drugs, with particular reference to the tricyclic diphenylamine and diphenylmethane derivatives, and the
relationships between chemical constitution and activity are
discussed. Special mention is made of the difference between
planar (ctlorproniazine type) and twisted (imipramine type)
ring systems. The article also contains sections on Rauwolfia
alkaloids, benzoquinolizines, and butyrophero ne and hydrazine derivatives. A report by R lfnwking on the “Chemotherapy of Filariasis” covers 27 pages A mncise description
of the types of Filarin that are important in clinical research
and of in vitro and iQ n v o evaluation methods precedes a
discussion of the chemotherapeutic agents of proven activity
in this field: diethyl-carbamazine, antimony, arsenic and
cyanine compounds, suramin, and bisquinolinium compounds. A very comprehensive article on “3,CDihydroxyphenylalanine and related compounds” is presei:ted by A . R .
Ptrtel and A . Brrr,yc?r(56 pp.). Comprehensive tables first give
the physical and chemical properties of the intermediates
and the yields in the synthesis of 3,4-dopa, its positional
isomers, and a number of derivatives. This Is followed by
analytical and pharmacological data on dopa. Finally, the
dopa decarboxylase inhibitors, particularly 3-methyldopa
are discussed and a brief section on 3,4-dihydroxyphenylserine concludes the article.
R . L . Smith contributes 54 pages on “The biliary excretion
and enterohepatic circulation of drugs and other organic
Atigew. Chem. intermit. Edit.
Vol. 6 (1967) / No. 4
compounds.” After a discussion of the mechanisms involved
in biliary excretion, the fate of the excreted products in the
intestines and their possible role as carcinogens are examined.
The author goes on to give a survey of the classes of substances that are predominantly excreted with the bile and the
constitutional factors involved. The article by K . Wiesner and
H. Fink on “Activity and side effects of metronidazol in the
treatment of trichomoniasis” presents a critical evaluation
of all the existing literature. For the reader’s guidance, the
numerical data from the various publications are reproduced
in tables (24 pp.).
The valuc of this work for orientation in the field of drug
research is enhanced by an excellent subject index for the
present volume and a n author and article index for the nine
volumes published so far. The presentation of the book is
0. Schairmann
[NB 557 IE]
once again excellent.
[*] Cf. Angew. Chem. 78, 831 (1966); Angew. Chem. internat.
Edit. 5, 854 (1966).
Compilation of Mass Spectral Data. By A . Cornu and R . Mussot. Published jointly by Heyden & Sons Ltd., London, and
Presses Universitaire de France, Paris 1966. 1st Edit.,
xv, 617 pp., cloth E 14.
Mass spectra, like I R spectra, are well suited to the characterizstion of organic compounds. Although many reference
spectra have been compiled in recent years, these exist
mainly in company collections and are not generally accessible.
In the present book, Curnu and Massot have compiled tables
of the data required for the mass-spectroscopic identification
of compounds (the intensity values of the ten highest peaks)
from a total of some 5000 spectra taken from such collections
and from the literature. It is easy to find a compound quickly,
since the tables are arranged according to the empirical
formula, the molecular weight, the strongest peaks, and the
source of the spectra.
Unfortunately, no line representations of spectra have been
taken into account in the compilation of the tables, though
this is the type of representation almost exclusively used by
organic chemists nowadays. Thus the collection does not
contain a single spectrum from the hundredor so fundamental studies by Djerassi. On the other, hand, the spectra
published several times in the API catalogue of mass spectra
also appear several times in the book for example, on pages
11B and 12B there are ‘five spectra of cyclohexene, distinguished only by a slight difference in the intensity values.
These differences are due to variations in equipment and
experimental conditions and are of n,o great experimental
importance. It was therefore unnecessary to give the intensity
values to a n accuracy of tenths of a percent, since such an
accuracy cannot be achieved in comparative work with
different instruments.
To summarize, it can be said that this collection of spectra
is very useful for the identification of thermally stable compounds (e.g. hydrocarbons, esters, and aromatic compounds),
the spectra of which could be recorded before 1960 by the
methods hsual at that time; however, the reader will search
in vain for spectra of such compounds as have been analysed
by mass spectrometry during the past five years. These
spectra already form a large part of the available data. This
defect could be overcome by the publication of a supple‘J. Spitrllrr
[NE 553 IE]
mcntary volume.
Light: Physical and Biological Action. Edited by H. H. Seliger
and W. D. McE1ro.v. Academic Press, New York-London
1965. 1st Edit., xi, 417 pp., several figures. $ 12.--.
The book is intended to give the beginner a general picture
of the problems and the state of photobiology. The first part
(Chapters 1 to 3) deals with the physical principles, and the
second part (Chapters 4 and 5 ) with the biological phenomena.
381
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