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Book Review Gene und Klone. Eine Einfhrung in die Gentechnologie. By E.-L. Winnacker

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All in all this is a successful work; the external appearance is pleasing and every page is strewn with useful information. The rigorous arrangement of the individual volumes enables quick orientation, even without recourse to
the index, and means that cross references can largely be
dispensed with. The numerous clear formula diagrams and
informative tables are very helpful. Preparative chemists
will particularly welcome the tabular grouping of the “best
methods of synthesis”.
The production of this work must have been a Herculean task for authors and editors alike. This deserves recognition and makes detailed criticism mere niggling. Spot
tests indicate that printing errors have been carefully expunged and that transcription errors do not exceed the
sadly inevitable limits. One striking example of this is the
citation of two different (by 1.98 eV) ionization potentials
for oxetane on the same page (Vol. 7, p. 368). It is unfortunate that “oxete”, the correct name for the unsaturated 4ring ether, is replaced even in a chapter heading by “oxetene” (Vol. 7, p. 363). In a few cases the chapters have
turned out to be pretty eclectic, as, for example, when 1,2and 1,3-dioxolanes as well as 1,2- and 1,3-oxathiolanes are
discussed in tandem, although they are cyclic derivatives
of quite different classes of compounds (Vol. 6, p. 749ff).
The selection of material by authors and editors is naturally subjective and some readers will find particular aspects missing or inadequately dealt with. Obviously, however, exhaustive treatment cannot be expected even in
42 cm of shelf space. Even so a survey of the subject and
an entry into further literature are provided. The general
chapters enable interested students to find their bearings
and could also serve as the basis for a lecture; for this reason this work should enable heterocyclic chemistry to find
a place in the curriculum that corresponds to its importance. The specialized chapters are available to meet the
demand for more detailed information. Even expert-in
universities or industry-will find useful references here.
Interested parties from neighboring disciplines will appreciate the extensive sections on applications and biochemical aspects. Quite apart from searching for particular information, the book is interesting territory for the browser;
even in the age of machine readable data this “semi-systematic” access to information is indispensable and will ensure a large readership for “Comprehensive Heterocyclic
Ernst Schazrrnann [NB 709 IE]
Institut fur Organische Chemie
der Universitat Hamburg (FRG)
Gene und Klone. Eine Einfuhrung in die Gentechnologie. By
E.-L. Wznnacker. Verlag Chemie, Weinheim 1984. xii,
454 pp., bound, DM 70.00.--ISBN 3-527-26061-7
Textbooks dealing with topics in molecular biology have
a very short half-life and become rapidly outdated. Courage and the ability to foresee future developments are
therefore required when one sets out to write a detailed
introduction into the concepts and techniques of gene
technology. Ernst-Ludwig Winnacker, with his book “Gene
und Klone”, has succeeded in making a contribution that
will not only be of value to novices in the field of molecular biology. In didactically exemplary fashion, the fundamental principles of molecular biology are combined with
the concepts and techniques of gene technology. The sequence of chapters reflects the experimental procedures
routinely followed in cloning experiments. Research in
molecular biology always involves genuine craftsmanship
that has to be mastered and modified daily on the basis of
the most recent developments. This practical aspect has
also been adequately dealt with by Ernst-Ludwig Winnacker’s presentation. The combination of theoretical considerations and practical instructions renders the book readable
for newcomers; accuracy in detail and the author’s efforts
to cover current findings make the book useful and worthwhile reading for advanced students as well. Essentials for
daily work are readily available by the inclusion of numerous, clearly drawn illustrations presenting genetic and
structural maps. In the appendix, the guidelines of the
“Zentrale Kommission fur die Biologische Sicherheit” are
also included. The reader should, however, be aware of the
fact that these guidelines are currently being revised.
Shortly before writing this book review, I wanted to leaf
through “Gene und Klone” again. 1 had to search for my
two copies in the laboratory. Only after days of questioning, however, was I able to find them. One copy had been
extensively used and showed it. Apparently, the book has
been consulted frequently by my younger colleagues. This
observation is perhaps the best recommendation for the
In Munich, it must be difficult to compete with the
“Schonheitengalerie” of the first Ludwig.“] Although the
gallery of molecular biologists presented by the Ludwig
who writes about genes and clones may render the cold
scientific facts more likeable, its attraction is in general far
inferior to the collection of the first Ludwig.
This book is highly recommended above all to students
in the field. I hope that the book goes through many, carefully rewritten editions and will be translated into English
after having been brought up-to-date.
Walter DoerJler [NB 724 IE]
Institut fur Genetik der Universitat Koln (FRG)
Hydrazine and its Derivatives. Preparation, Properties, Applications. By E . W . Schmidt. Wiley, Chichester 1984.
xxv, 1059 pp., bound, f 87.00.--ISBN 0-471-89170-3
The major sections of this book are: the production of
hydrazine (including the anhydrous compound), together
with details of the capacities of and processes employed by
western manufactures ; physical properties ; chemical properties of hydrazine and its salts with a detailed section on
hydrazine analysis; the handling of hydrazine with a very
important subsection on its toxicology; the decomposition
of hydrazine; utilization of hydrazine, especially its use as
a rocket propellant whose description occupies more than
100 pages.
Organic derivatives are described only very briefly and,
essentially, only insofar as they are of importance to the
field of rocket propellants.
As the author, who is a senior staff scientist of the
Rocket Research Corporation and obtained his doctorate
in Tubingen, correctly states, this is the first comprehensive survey of hydrazine in an occidental language for the
last 30 years. For all who are doing work in the field of
hydrazine the absence of such a book has been a significant handicap.
Here too, as in many other fields, the literature has exploded. The reference list contains more than 4400 citations on 194 pages. The references are listed “lexically”,
that is alphabetically according to the name of the first author, so that the list fulfills some of the functions of a n
author index.
Ludwig I., King of Bavaria (1825-1848), had portraits of the most beautiful Munich women painted for his “Schonheitengalerie”, which is now
exhibited in Schloss Nymphenburg. Go and see it.
Anyew Cliem. Inr. Ed. Enyl. 24 (1985) No. I 1
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