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Book Review Handbuch der Gaschromatographie. Edited by E. Leibnitz and G. Struppe

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there in the book but surely deserves a more detailed treatment.
Preparative chemists will find useful the tables that follow the main chapter, in which are grouped important
types of educt, reduction reagents and products. These
tables refer back into the main body of the text and thence
to an extensive literature index.
The last part of the book consists of fifty experimental
procedures for the preparation of special reduction reagents and for the reduction of representative compounds.
Since the compounds chosen have got quite simple structures, these procedures can serve only as a guide; for more
complicated molecules it would certainly be advisable to
consult the original literature.
This book does not, then, offer a critical view, but
simply a superficial description of the extensive arsenal of
reduction methods. For the practical chemist there is useTul guidance, especially in the numerous tables and experimental procedures. The very high price is bound to stand
in the way of purchase for everyday use.
Franz-Peter Montforts [NB 712 IE]
Institut fur Organische Chemie
der Universitat Frankfurt (FRG)
Handbuch der Gaschromatographie. Edited by E. Leibnitz
and G . Struppe. Akademische Verlagsgesellschaft Geest
& Portig, Leipzig 1984.828 pages, hardback, DM 198.00.
Order No. 669-628-5 (Sole distributors for the FRG:
W & P Buchversand fur Wissenschaft und Praxis, Weinheim, ISBN 3-89141-001-8)
This handbook, compiled by an authors’ collective,
amounts to a comprehensive treatment of all aspects of gas
chromatography, which is certainly not lacking in detailed
information. This is an area of chemistry which is rapidly
developing and even a freshly published work is bound to
be partly out of date at the time of publication; however,
the new edition of this handbook does cover in supplements more recent techniques for sample introduction (e.g.
“on column injection”), modern methods of coupling, column connections, flexible quartz capillaries, chemically
immobilized stationary phases etc., even if not in close detail.
There are successful chapters on the principles and development of gas chromatography, capillary columns, detectors, quantitative analysis (albeit almost exclusively on
“packed” columns) and the coupling of gas chromatography with spectroscopic methods. Packed columns, whose
significance is diminishing these days, are rather overemphasized in two extensive chapters. It may be a drawback
of this new edition that the increasing trend towards use of
capillary gas chromatography is not sufficiently recognized. The admittedly difficult problems encountered in
quantitative analysis with capillary columns are only
briefly discussed.
The treatment of stationary phases is very comprehensive but a supplement covering newer literature on the use
of chiral stationary phases would not have come amiss. Likewise, there is no reference to complexation gas chromatography and the work of V. Schurig. The chapter on derivatization reactions is also in need of supplementation:
much of the newer literature is not included here. However, the handbook does contain chapters on such industrial
aspects as process control, process regulation and automation. The physico-chemical basis of the different methods,
the theory of temperature programming and many fundamental concepts are given detailed and comprehensible
This handbook not only offers the user, whether involved in industrial or academic research, many hints for
the optimization and the solution of separation problems,
it also provides fundamental knowledge in this area of
physical chemistry.
Wilfied A . K6nzg [NB 716 IE]
Institut fur Organische Chemie
der Universitat Hamburg (FRG)
Macrolide Antibiotics. Chemistry, Biology and Practice.
Edited by S. amura. Academic Press, Orlando 1984,635
pages, hardback, $ 89.50.--ISBN 0-12-526450-X
Professor Satoshi grnura (Kitasato University Tokyo) is
surely currently by far the best authority on the chemistry
and biochemistry of macrolides. His book on the chemistry, biology and applications of macrolide antibiotics is
correspondingly comprehensive. He has succeeded in
gathering a group of renowned authors about him so that
the content of this book goes far beyond his own field of
interest, and even includes the application of macrolides in
human and veterinary medicine.
A good half of the book is devoted to classical macroIides of the erythromycin and carbomycin type, the subgroup of macrolides which has found the broadest medical
application. The chapters on the determination of constitution and configuration, on chemical modifications and
structure/activity relationships, and on regulation of biosynthesis and the genetics of macrolide production are
sound and contain extensive literature references. Especially pcnetrating is the description by S . Masamune of the
total synthesis of macrolides. An easily grasped model of
the structure and mode of function of ribosomes serves as
the basis for J. W. Corcoran’s chapter on the mode of action and resistance mechanisms. This section gives some
idea how much fundamental research in biochemistry and
molecular biology owes to the use of antibiotics. The sections on macrolides in clinical ( I . Nakayama) and veterinary ( R . C. Wilson) use may be too brief for medical practitioners. However, they provide a valuable survey of the
application of macrolide antibiotics for the chemist or biochemist.
The quite appreciable second part of the book is devoted to fungicidal polyene macrolides, of which some
(e.g. amphotericin B, nystatin) have found medical application, albeit limited. This part is arranged similarly to the
first and owes its completeness to the contributions of H .
Tanaka (structure and fungicidal activity), J. F. Martin
(biosynthesis, regulation and genetics), E. F. Gale (mode
of action and resistance mechanisms) and C. P. Schaffner
(clinical practice).
To keep the size of the book under control, the “macrolide-like” antibiotics from actinomycetes have been handled in a much more condensed way, even though a series
of biogenetically and structurally most interesting compounds have recently been discovered here. To these belong, e.g., chlorothricin and nargenicin, as well as metabolites with high fungicidal and cytotoxic activity, like oligomycins, venturicidins and concanamycins. However, a
good literature register enables access to these compounds
as well. This applies too for the numerous fungal macrolides with quite diverse biological effects, for macrodiolides
Anyew. Chem. Int Ed.
Engl. 25 11986) No. 6
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