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Book Review Host-Guest Molecular Interactons. From Chemistry to Biology. (Series Ciba Foundation Symposium No. 158.)

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A,
h = 11 7788(9), c = 23 240(4)
2 = 4, f l = 98 571(9)", pIalOd
=
1 592 gem-', 4548 unique reflections with I > 341) yielded R = 0 054,
R, = 0 076 Further details of the crystal structure investigations may be
obtained from the Fachinformationszentrum Karlsruhe, Gesellschaft fur
wissenschaftlich-technische Information mbH, D-W-7514 Eggenstein
Leopoldshafen 2 (FRG), on quoting the depository number CSD-56378,
the names of the authors, and the journal citation
[6] 2a 'H NMR (C,D,, 30°C) 6 = 0 33 (s, Nb,CSiMe,), -0 77 (s, CCSiMe,), 0 13, 0 81 (t. CH,CH,), 1 56, 2 32 (br , CH,CH,), I3C NMR
(C6D6, 30°C) 6 = 5 6 (Nb,CSiMe,), 1,3 (CCSiMe,)
2b 'H NMR
(C,D,, 30 "C) 6 = 0 34 (s, Ta,CSiMe,), -0 75 (s, CCSiMe,), 0 21,O 84 (t.
CH,CH,), 1 85, 2 40, 2 68 (br , CH,CH,), 8 71 (d, orfho protons of cb,
6 59 (t, mela protons of cb I3C NMR (C,D,, 30°C) 6 = 6 7 (Ta,CSNe,),
1 4 (CCSiMe,), 16 0 (CH,CH,), 27 2, 27 7 (CH,CH,), 253 9 (CCSiMe,),
257 3 (CCEt), 393 0 (Ta,CSiMe,)
[71 L R Chamberlain,I P Rothwell, J C Huffman, J A m Chem Soc 1982,
104 7338
[XI
3b Analysis calced for Ta2C6,H6,N,Si3 C,H, C 58 87, H 4 94, N
4 0 4 % ,f o u n d C5 8 1 3 ,H 5 O 3 ,N 4 0 O 0 h
[9] A single-crystal X-ray diffraction analysis of 3 a has been carried out, it
confirms the formulation of the compound as a dimetallabenzene derivative and clearly shows four equivalent Nb-C and two equivalent C-C
distances within the ring 3 a ' H N M R (C,D,, 30°C) 6 = 0 0 7 (s,
Nb,CSiMe,), - 0 70 (s, CCSiMe,), 8 43 (s, CH), 8 60 (d, ortho protons of
;b),I3C NMR(C,D,,?O"C) 6 = 5 8 (Nb,CSiMe,),O 1(CCSiMe,) - 3 b
H NMR (C,D,, 30 "C) 6 = 0 14 (s, Ta,CSiMe,), - 0 63 (s. CCSiMe,),
8 64 (s, CH), 8 73 (d, orfho protons of cb), I3C NMR (C6D,, 30°C)
6 = 5 6 (Ta,CSiMe,), - 0 3 (CCSiMe,), 255 0 (CCSiMe,), 386 5
(Ta,CSiMe,)
[lo] a) R R Schrock, J Organornet Chem 1986,300,249, b) A t c Chem Res
1986, 19, 342
[l11 The possibility of tungstabenzene intermediates in alkyne metathesis has
been discussed by J H Freudenberger, R R Schrock, M R Churchill,
A L Rheingold, J W Ziller, Organometallics 1984, 3, 1563
BOOK REVIEWS
Book Reviews are wntlen by invitation from the
editor. Suggestions for books to be reviewed and
for book reviewers an welcome. Publishersshould
send bmchures or (better) books to the following
addms: Redaktion hgewandtt? Chemie, Pastfach 101161, D-W-6940
Weifdrcim, Federal Republic of Germany. The &tor m m e s the light of
selecting which books wit1 be reviewed. Uninvited
books nat chosen for review will not be mturtted.
Host-Guest Molecular Interactions. From Chemistry to Biology. (Series: Ciba Foundation Symposium No. 158.)
Wiley, Chichester, 1991. IX, 278 pp., hardcover&39.50.ISBN 0-471-92958-1
Under the auspices of the Ciba Foundation, a symposium
on molecular recognition was held in London at the beginning of July 1990. The 15 papers presented at this small but
illustrious gathering have provided the material for the book
reviewed here. Following an introduction by I. Sutherland,
the first paper is a contribution by J. F. Stoddart on the
application of charge-transfer interactions to the synthesis of
catenanes and rotaxanes. Next G. W. Gokel reports on experiments aimed at creating artificial ion channels based on
crown ether derivatives. This is followed by an applicationorientated contribution by D. N. Reinhoudt, on the problem
of converting chemical information into electrical signals.
The required selectivity can be obtained by using synthetic
host molecules; for example, calixarene is the basis for a
field-effect transistor responding to potassium ions. However, it is also possible to use enzymes for specifically converting substrates into products that can be detected electrochemically, and W. J. Albery describes how this method has
been successfully used for in-vivo determination of blood
sugar content. Next comes a report by J. P. Waltho and
D. H. Williams on complexes between antibiotics of the vancomycin family and peptides, then an article on J. Rebek's
well-known receptor molecules for adenine etc., which are
derived from Kemp's tricarboxylic acid. The contribution by
R. Breslow describes cooperative effects of bifunctional molecules in the binding of substrates, in the catalysis of
Angew Chem. Int. Ed. Engl. 1992, 31, No. 9
0 VCH
supramolecular reactions, and in connection with the triggering of differentiation processes in tumor cells.
The second half of the book is mainly concerned with
biopolymers, starting with nucleic acids and their complexes
with antibiotics (M. Waring). N. T. Thuong and C. Helene
describe conjugates of oligonucleotides with acridine that
make possible sequence-selective binding to DNA through
the formation of triple helices. This topic is taken further in
a report by M. H. Caruthers on the preparation and properties of dithioate-modified DNA. The next four articles are
concerned with the structural self-organization of proteins
and enzyme-substrate complexes. G. C. K. Roberts describes NMR studies on dihydrofolate reductase, R. I. Carey
and M. Mutter report on synthetic proteins with templatecontrolled folding behavior, A. B. Edmundson contributes
an article on the binding of peptides to immunoglobulins,
and R. U. Lemieux describes studies on the stability of complexes between various modified tetrasaccharides and a lectin. The lectin results reported by Lemieux generated new
speculations concerning the role of associated water molecules in the association of amphiphilic surfaces, and the discussion of this is reported here. The book concludes with an
article by J. G. Vinter on molecular modeling approaches to
the description of host-guest interactions.
Conference reports published in book form have certain
unavoidable drawbacks, namely the lack of uniformity in the
individual contributions, a relatively high price due to small
print runs, and above all the fact that similar articles by the
same authors can often be found in the regular journals, and
sometimes already exist when the book appears. This volume
is no exception in the latter respect, and, moreover, the articles are all very brief. However, this certainly does not mean
that the book is superfluous, since by including an account
of the discussions it achieves something that an individual
paper cannot do, that is to convey something of the spirit of
a conference in which the lively exchange of views reveals
new aspects of the work reported. These discussions, which
also include literature references and diagrams to make the
main points clear, are given an appropriately large amount
of space. In addition three "General Discussions" on important topics of interest are included. The volume is completed
by a list of participants, an author index, and a brief subject
index. The material has been carefully put together, and the
standard of printing and production is good. This book is
certainly of value for everyone interested in the subject.
Michael Gobel
Institut fur Organische Chemie
der Universitat Frankfurt (FRG)
Verlagsgesellschaft mbH, W-6940 Weinheim, 1992
0570-0833[92~0909-1263$3.50+ 2510
1263
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