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Book Review In Vitro Methods in Cell-Mediated Immunity. Ed. by B. R. Bloom and P. R. Glade

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It contains the standards on terminology and abbreviations,
binders, solvents, driers, softeners, pigments and fillers,
paints and similar coating materials, and color. The very
wide field of pigments and fillers is broken down into
general test methods, white pigments, colored pigments,
luminous pigments, carbon blacks, and fillers.
The aquisition (and the frequent use) of this pocket book
can be strongly recommended to all practical workers.
Heinz Rechmann [NB 78 IE]
Atomic and Molecular Radiation Physics. By L. Christophorou. John Wiley & Sons Ltd., New York-London
1971.1st ed., x, 672 pp., numerous figuresand tables, bound
L 10.50.
The book deals with the processes in the eV to keV range
that occur on interaction of electrons, ions, and photons
with individual atoms and molecules. Processes in liquids
and solids are merely touched upon. It should be stressed
that triatomic and polyatomic molecules are included in
the discussion. The physical principles are presented
clearly before the description of the experimental methods
and the results obtained by these methods. Practically all
the results mentioned are supported by references ; this
enhances the value of the book, since original papers up
to and including 1969 are covered.
The book is divided into nine chapters. The first two deal
with the deceleration and the resulting total ionization
during the passage of ionizing radiation through matter.
The next six chapters form the main part of the book, and
deal with the processes that are brought about in or on
atoms and molecules by photons, electrons, and ions:
photophysical processes ; elastic scattering of slow electrons ; inelastic scattering of electrons; negative ions;
electron detachment from negative ions and electron affinities of atoms and molecules; interactions between heavy
neutral and charged particles. In the concluding chapter
on biophotophysics and bioelectronics, reference is made
to the importance of the physical understanding of molecular processes to biological problems, with the development of cancer as an example. The appendix contains
ionization potentials of atoms, molecules, and radicals,
some physical constants and conversion factors, and the
periodic table and the table of radioactive isotopes. An
author index and subject index are included. The book
can be recommended to anyone who wishes a general
picture of the present position of knowledge on the interactions of photons, electrons, and ions with free atoms and
molecules in the low-energy range.
Hans Steidf [NB 82 IE]
In Vitvo Methods in Cell-Mediated Immunity. Ed. by B. R .
Bloom and P . R . Glade. Academic Press, New York-London 1971, 1st edit., xxiv, 578 pp., numerous figs, bound,
At a conference held in April 1969 at Brook Lodge on
“Mediators of Cellular Immunology” it became apparent
how greatly the clarification of the mechanisms of cellular
immunity depended upon suitable in-citro methods. These
in their turn became the subject of a symposium held at
the New York University, Bellevue Medical Center, New
York, on May 28-29, 1970. The present book is an edited
version of the discussions at this meeting, supplemented
by an extensive section on the methods used.
The topics discussed are the characterization of the currently
known supposed mediators of cellular immunity by simple
chemical and physical parameters and their differentiation
from one another (some short summary tables on this are
given at the end of the book), the appropriate in-uitro
systems, which are described by several of the participants
and subsequently freely discussed and criticized, the
correlation with in-uiuo phenomena, and starting points
for the development of new experimental systems.
The second part of the book consists of a clearly arranged
description of 37 experimental in-uitro systems, by means
of which the following phenomena may be studied: cell
migration (particularly macrophage migration and related effects on macrophages), cytotoxicity of lymphocytes.
lymphocyte transformation, inhibition of cell growth,
chemotaxis, production of skin-reactive factor and of
interferon, transference of delayed type of skin reactivity
by transfer factor, and intracellular virus multiplication.
A guide to the cultivation of human lymphocytes in longterm cultures is also given.
One great advantage of this book is that the methods
represented are not merely described but are also discussed
in an extremely lively fashion. It is true that this makes it
difficult to obtain a good allover view, but this disadvantage
is far outweighed by the wealth of suggestions and critical
objections arising from the discussions. The extensive
practical section which derives from the contributions of
well-known scientists, in many cases the originators of the
systems in question, is impressive in the clarity of its
arrangement and in the precision and detail of its descriptions.
The book is highly recommended to all immunologists and
immunological chemists active in this field.
Giinter Sommer [NB 79 IE]
Organisch-chemischesPraktikum (Practical Organic Chemistry). By G. Kempter. Vieweg Verlag, Braunschweig 1971.
1st edit. 203 pp., 85 figs., bound, DM 9.80.
This is a brief practical manual produced by the author
and a group of associates for students who are taking
chemistry as a subsidiary subject. An introduction to
instrument technology is followed by expositions on safety
and fire precautions and on general methods (melting point,
sublimation, distillation, rectification, and chromatographic methods). The organic experiments which foIlow
are arranged by type of reaction. Each set of operating
instructions is preceded by a brief theoretical introduction.
Access to the literature is simplified for the student by a
short introductory chapter. The book ends with sections
on qualitative analysis and on ultraviolet and infrared
spectroscopy. Each chapter is accompanied by test questions and practical exercises.
An attractive feature of the book is its compact and precise
presentation, together with the clarity of the figures and
formulas. The experiments to be carried out are simple,
in accordance with the level of experience of the intended
readership. In the reviewer’s opinion the theoretical introductions are too short, for in many cases they do no more
than show the student the concept he will need to study
more thoroughly in a textbook. In addition, the brevity of
the entries sometimes leads to the risk of making false
statements due to excessive simplification (e.g. p. 74, nucleophilic substitution by eNO, ; p. 97, 1st section on polyAngew. Chem. inlernat. Edit./ Vol. I 1 (1972)
1 No. I 1
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glad, book, method, review, immunity, vitro, blood, cells, mediated
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