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Book Review Klinische Chemie Theorie und Praxis (Clinical Chemistry Theory and Practice). By R

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Methoden der organischen Chemie (Methods in Organic
Chemistry) (Houben-Weyl). Edited by Eugeiz Miiller, Vol.
XII, Part 2. Organische Phosphorverbindungen (Organic
Phosphorus Compounds). Compiled by K. Sasse. Georg
Thieme Verlag, Stuttgart 1964. 4th completely revised
Edition, LXXXVII
1 I 3 1 pp., 195 tables, one diagram,
D M 280.-.
The user of Part 1 of “Organische Phosphorverbindungen”
will have eagerly awaited the publication of the present Part 2.
This part deals with compounds containing no phosphoruscarbon bonds, i.e. mainly with compounds that can be
regarded as derivatives of phosphoric and phosphorous
acids. Variation of the nature and number of organic
groups, replacement of oxygen by sulfur, halogen or nitrogen,
anhydride formation, etc., permits the derivation of an
almost countless number of types of compounds.
Kosolapyff’s monograph “Organophosphorus Compounds”
(which now, fifteen years after its publication, is no longer
adequate) has until now been the only existing review of this
subject. A complete account of the field as a whole is difficult, not only because of the volume of the relevant literature,
but also because of its heterogeneity. Owing to the great
technical importance of these compounds (as insecticides,
plasticizers, erc.), a very large proportion of the literature
is represented by patents. Moreover, many important
original papers have appeared m Russian journals, which are
not always accessible. The fact that, in spite of such difficulties, a single author fras managed to compile a complete
and comprehensive reviewican be regarded as an achievement
of the highest order in the fie1 of scientific literature.
Part 2, like Part 1, is arranged according to classes of compounds. For example, the 0,0 dsesters of thiophosphoric
acid are discussed in the section of “Organic derivatives of
phosphoric acid Derivatives of thiophosphoric acids”,
under “Esters and ester halides of thiophosphoric acids”.
The thiophosphoric acids are divided into 24 sub-groups.
The preparation and transformations of the various types
of compounds are described in special sections. The preparative procedures are grouped according to starting materials, and are illustrated by representative examples. Many
tables are included to show the compounds prepared by
given methods. The short section o n “Transformations” can
be confined to little more than a brief list of properties
together with a few notes, since the “transformation” is
generally discussed in detail under “Preparation”. The
subject index contains about I0000 compounds.
T o sum up, it can be said that K . Susse has produced a new
standard work on the organic chemistry of phosphorus. In
view of the rapid progress being made in this field, however,
it is impossible to predict how long it will be valid. In any
case, by virtue of the numerous suggestions offered, the
book will undoubtedly make a considerable contribution to
further progress and hence to its own “obsolescence”.
H. Hofmnnrz
[NB 421/292 IE]
Nuclear Techniques in Analytical Chemistry. By A . J. Moses.
International Series of Monographs on Analytical Chemistry. Edited by R . Belcher and L. Gordon. Pergamon Press,
Oxford - London - Edinburgh - New York - Paris - Frankfurt
1964. 1st Edit., VII + 142 pp., numerous illustrations and
tables, 1 color plate, & 2.5.0.
There is probably no other branch of chemistry in which
radiochemical methods find such varied and valuable use
as in analysis.
The present book, which describes the principal analytical
applications of radiochemical methods (i. e. the methods of
activation analysis, isotope-dilution analysis, radiometeric
measurements, etc.), is therefore very welcome. However,
those who hope to satisfy completely their thirst for knowledge in this field will be disappointed in many places; thus
the book repeatedly recommends special methods of measurement or special practical procedures, but when the eager
reader then seeks for details, he finds that he has to turn to
other publications. On the other hand, where a method is
described in dctail, the description is very well presented and
is supplemented by pzactical directions.
The value to the reader would have been greater. however,
had the author commented on the directions, since these
alone frequently do not explain to the inexperienced worker
the need for a special procedure. Nevertheless, the reader
will undoubtedly be pleased by the comprehensive bibliography provided.
F. Bnrirngartner
[NB 427’291 I€]
Radionuklid-Tabellen (Radionuclide Tables). Compiled by
W. Seelmnnn-Eggebert and G. Pfennig; published by the
Bundesministerium fur wissenschaftliche Forschung. Ver:
lag Gersbach & Solin. Munchen 1964. 1st edit., 79 pp.,
cardboard D M 4.- - ($ I .OO).
The booklet lists the radionuclides in order of increasing
nuclear charge, nuclides of the same element being arranged
in order of increasing mass number. Owing to this simple
arrangement, it is easy to find any given radionuclide. The
types of decay, abundancps, half-lives, and radiation energies
are given for each nuclide. The table also gives the conversion
coefficients and daughter nuclides, so that all the essential
data are reported. Two additional tables show the estimated
yields of a number of longer-lived fission products from
tomic explosions and the cumulative yields for various
fission reactions. Two diagrams are included to show the
time-depenaence of the percentage contributions of longerlfved fission products from atomic explosions to the total
This book is an indispensible aid to all who work with
radionuclides. Its publication is therefore very welcome, and
its low price places it within the reach of all.
W . Strohmeier [NB 412,/284 IE]
Klinische Chemie, Theorie und Praxis (Clinical Chemistry,
Theory and Practice). By R. Richterich. Akademische Verlagsgesellschaft, FrankfurtjM., S. Karger AG.. Base1 1965.
416 pp., 76 illustrations, 89 tables, D M
1st Edit., XI1
59.50 (about S 15.-).
This new book by Richtericli (whose Enzyme Pathology,
which was published in 1957, is still a valuable reference
work) is unusual in several respects. On glancing through it,
one is impressed by the excellent layout. The divisions of the
individual chapters are well marked and attention is drawn
to important details by the use of “boxes”. The divisions
(in the case of experimental procedures these are: principle,
reagents, procedure, calculation, and normal values) are
marked in the margin, and this arrangement quickly familiarizes the reader with the book. It would be very gratifying if this clear, concisepstyle were to become generally used
in textbooks!
It is also unusual, at least in German-language books, to find
advertisements in an appendix. However, anyone who has
experienced the difficulty of equipping a small clinicalchemistry laboratory with apparatus and reagents will
applaud the author’s and publishers’ courage in introducing
this novel feature. It is to be hoped that the size of this
appendix will be doubled in the next edition.
The book is not a reference work and is not claimed to be
exhaustive; it can probably be best described as an introduction to clinical chemistry. It is accordingly dominated by the
chapters on units of measurement, introduction to statistics,
Angew. Chem. internat. Edit. 1 Vol. 5 (1966) / No. 2
normal values, reliability of samples, the sampling of blood,
ctc. Thc author makcs many references to his own practiczl
experience in this field. This can be seen already from the
Table of Contents, which includes a code used by the author
for classification purpsses and as a key for punched cards.
Having been pampered by these excellent chapters on general
clinical chemistry, which serve as an introduction to the
special chapters, the reader becomes aware of the following
shortcomings when he turns to the special chapters themselves: The arrangement of the material becomes unclear
when he tries to refer to the book for details of methods. For
example, the enzyme determinations are to be found in a
number of different chapters. Furthermore, the selection of
methods included is very narrow, and a number of important
clinical determinations, such as the determination of iron,
are omittcd altogether.
However, this criticism ignores the aim of the book. As the
author himself stresses in the preface, the emphasis is placed
o n the general part, which will still be valid when all the
special methods are obsolete. It is to be hoped, and indeed
it can almost be predicted, that this book will enjoy a very
wide circulation.
F. W . Schmidt
[NB 422/293 IE]
Handbuch der physiologisch- und pathologisch-chemischen
Analyse, fur Arzte, Biologen und Chemiker (Handbook of
Physiological and Pathological Chemical Analysis, for
Physicians, Biologists, and Chemists). By Hoppe-Seyler;
Thierfelder, edited by K . Lang and E. Lehnartz, with the
collaboration of 0. Hoffmann-Ostenhof and G . Sieberr.
Vol. 6. Enzymes, Part A. Springer-Verlag, Berlin-Gottingen-Heidelberg-New York 1964. 10th Edit., XX 1052pp.,
119 illustrations, D M 360.-(subscription price DM 288.-).
lases (Abra/zam et al., 131 pp.) are dealt with in great detail,
the practical procedures being acc3nipanied by a wealth of
literature data such as cannot be found in any ot!ier review
of this nature. Thus for information on any properties of
these enzymes, these chapters offer a fine source. Other
enzymes are dealt with much more briefly, the discussion
being confined to practical procedures, as would be expected
in a book on methods; this is the case with succinate dehydrogenase (Slater, 5 pp.), the copper enzymes (Schirrnitrcher-Gollner, 19 pp.) (uricase also is a copper enzyme!).
“malic enzymes” (Rutrer, 10 pp.) (the name “malic enzymes”
should no longer be used!), and the “yellow enzymes” (N?,guard, 34 pp.). It is surprising to find that the flavin enzymes
are accorded only about 50 pages (nitrate reductase is discussed
in a single page, while no mention is made of the other enzymes
that act on other N compounds and inorganic S csmpounds,
or of e.g. dehydroorotic acid dehydrogenase), whereas the
pyridine nucleotide dehydrogenases are spread over about 500
pages. Disparities exist between the various chapters, which
suggest that the authors were allowed to decide for themselves
how much detail to include in their own contributions.
In view of the high price of this book, it is regrettable that
much of the literature cited extends only to 1960 or 1961, S O
that by the time of publication (November 1964), some
chapters were largely out of date. This is particularly true
for glucose 6-phosphate dehydrogenase (the enzymes from
yeast and from bovine mammary glands were crystallized
in 1961) and glutamic acid dehydrogenase. It is advantageous
when the dates OF the latest publications considered are
given, as is done on pages 423 and 917.
Apart from these criticisms, the present volume will be
a valuable aid to the enzyme chemist, and will provide
him with a wealth of information. I n many cases, he will
be able to carry out estimations and preparations without
recourse to the original publications. The usefulness of this
volume will be greatly increased when the index, planned
for Volume C, becomes available. It is to be hoped that
it will then be possible to report o n the hemin enzymes.
The print (on yellow paper!) and layaut of the book are
[N B 426,196 I El
H . Sund
Enzymatic methods are finding increasing use in quantitative
analysis, and they have become indispensable in biochemical,
clinical, and forensic medical laboratories. We therefore
welcome the publication of this, the last volume of “HoppeSeyleriThierfelder”, which was originally intended to
comprise only 5 volilmes. present book is the first of
three parts of Vol. 6.
The first third of this sub-volume cmtains the general
chapters on nomenclature and methods. H o ~ m n n n - O s t e n h ~ ~ ’ Advances in Drug Research, Vol. I . Editcd by N . J . Harper
dcscribes the classification and nomenclature of enzymes
and Alma B. Simmonds. Academic Press. London-New
as well as enzyme units in a short, clear summary of
York 1964. 1st Edit. X + 209 pp.. numerous tables and
the “Report of the Commission on Enzymes”, published
seveyal illustrations, G 2.10.0.
in 1961. Unfortunately, the rules given here and on page 348
In the first chapter, Doyle and Nnylsr review the chemical
are only partly adopted in the book. For example, the
structure and action of penicillins and relate3 c3mpounds.
“suggested abbreviations” on page 19 do not correspond to
This review is competent and up-to-date, and even includcs
thoserecommended by the Enzyme Commission, and it is partia discussion of the new cephalosporins. The pharmacalogy
cularly confusing when NAD and DPN+ or NADPHl and
of therapeutically interesting compounds, o n thc other hand.
T P N H are used sidc by side. An instructive introduction to
is dealt with rather briefly.
enzyme kinetics (Lumper) should enable even workers with
chapter by L. S . Schlanker on the physiological transport
little experience to carry out a detailed and correct evaluation
of drugs contains fundamental observations on passive
of kinetic experiments. The manometric methods arc distransport and on the possibilities of resorption in the gastrocussed (Siiilmann) lucidly and at some length (224 pp.); this
intestinal tract in relation to the physical conditions. Short
is followed by a brief outline of the use of the pH-stat
sections are also devoted to transport processes in the various
(Cunningham) and a detailed account of the important Warorgans
of mammals. The review as a whole is well organized
burg optical test (Biicher, Luh, Perte). The scope of this
and very informative.
method is clearly shown in this discussion: almost any
The chapter on antitussives by Doyle and Mehta begins with
enzyme or any metabolite can be determined optically. A
a description of the coughing reflex and methods of testing
chapter on the measurement of phosphate uptake during
the inhibition OF coughing. The many cough-inhibiting
oxidative phosphorylation (Klingenberg) completes this excompounds are considered from the chemical point of view,
cellent general section; probably the only important omissions
but the pharmacological aspects are also taken into account.
are fluorescence methods and automatic methods.
The result is a comprehensive review.
The description of the enzymes, which are classified according
S . C . Copp reviews adrenergic neuron blocking agents. A brief
to the five principal groups given in the “Report”, begins
description of the methods used for the detection of pharwith the oxidoreductases. This volume includes the pyridine
macologicaf action is followed by a discussion of the active
nucleotide and flavin enzymes, as well as the copper enzymes
substances discovered so far. This chapter also is written
and hydroxylases. A number of chapters, e . g . those on
largely from the point of view of structure and action. Most
steroid dehydrogenases (Breuer, 125 pp.), isocitric acid deof the substances discussed are related to bretylium or
hydrogenase (Siebert, 27 pp.), 3-phosphoglyceraldehyde deguanethedine. The beta-receptor blocking substances are not
hydrogenase (Mohn, 58 pp.), “lesser known pyridine nuconsidered. This chapter provides a particularly good picture
cleotide enzymes” (Mohn, 99 pp.) (are they really lesser
known ? The literature reference is ambiguous) and hydroxyfor the chemist.
M. Kramer
[NB 41 1/283 IE]
Angew. Chem. internat. Edit. [ Vol. 5 (1966) 1 No. 2
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