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Book Review Methoden der Analytischen Chemie. Eine Einfhrung. Band 2 Nachweis- und Bestimmungsmethoden Teil 2. By R

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are chemists, biologists or physicians. Reference is necessary to other works for unambiguous identification. The
problem could have been avoided by enlarging the index
and cross referencing. Once the reader has taken this hurdle successfully, he then has to deal with a large number of
abbreviations that could cause difficulties to the occasional user. However, these allow a very compressed presentation in a small space.
The monographs should not be regarded as critical evaluations suitable as primary information for the non-specialist in presenting the metabolic fates of individual pharmaceuticals, because significant data are accompanied to
some extent by non-confirmed data without differentiation. This work is, however, a very comprehensive collection from the literature concerning the chosen substances
and provides easy access to the primary literature necessary for intensive study.
The collection of monographs is very useful as a reference work and is likely to be welcomed by all who are concerned with the biotransformation of pharmaceuticals, because even today a comprehensive literature search is
often time-consuming, at least as far as the older literature
is concerned.
The constantly increasing number of publications dealing with biotransformations and pharmacokinetics makes
a new form of documentation necessary in order to guarantee greater topicality; the authors are now making efforts in this direction. These volumes retain their importance as basic information concerning the substances covered.
K.-0. Vollmer [NB 678 IE]
Godecke AG, Abt. Biochemie,
Freiburg (FRG)
Cytochrome P-450. By K . Ruckpaul and H . Rein. Akademie Verlag, Berlin 1984. 405 pp., hardback, ca. DM
80.00.-Order No. 763-1 10-9 (6703)
“At last”, you may wish to say, along with the many biochemists, pharmacologists, microbiologists or chemists
who hope to find under a title like this everything they always wanted to know about cytochrome P450. There is,
without doubt, a gap in the market, which no-one has been
brave enough to fill yet, for a comprehensive and, above
all, systematizing monograph on cytochrome P450. This
may well be because of the constant development of ideas
about this cytochrome which does not exist as “the” cytochrome P450, whose description as “P450” follows no
rational nomenclature, and which, strictly speaking, is not
even a cytochrome.
Admittedly, it is difficult to bring order into the mass of
results that have been published about cytochrome P450.
It is difficult to separate the wheat from the chaff so that
the important findings will open the way, for specialist and
interested layman alike, to the unusual enzymology, the
mechanistic features-of significance to chemists alsoand the physiological, pharmacological, and toxological
aspects of this enzyme. This task is not made any easier
when it is entrusted to 25 authors, who deal with the significant aspects in eight chapters. The first six chapters are
almost exclusively concerned with the unspecific microsoma1 monooxygenase system of the liver. To this extent the
title of the book is undeserved in that some introduction to
common structural features and to mitochondrial, bacterial, and microsomal monooxygenases might have been expected, as well as a survey of the individual enzymes.
294
The camphor hydroxylating system, which is dealt with
in only six pages in chapter 7, is surely under-represented
and it would probably have been more easily understandable to the reader than the very complex drug monooxygenating system. The phenomenon of induction, which is so
important for this P450 system, appears in chapter 6 but is
already presupposed in chapter 2. Also, differing designations for “monooxygenases”, such as MFO (mixed function oxidases) or “monooxygenatic systems” d o not promote the comprehension of the student or non-specialist.
However, for the specialist the book contains a wealth of
details with an almost complete literature compilation on
the mechanistic aspects. Each chapter is competently written in itself, since the authors, nearly all from the central
Institute for Molecular Biology at Buch in (Berlin-East),
have all made appreciable contributions in their own
fields. Thus, K . Ruckpaul and R . Bernhardt present a good
survey of the endoplasmic reticulum, G. R . Jiinig and D .
Pfeil contribute an extensive treatment of the enzymology
of the liver system, and H . Rein, C. Jung, 0. Ristau and J.
Friedrich collate all the structural data on P450.
The chapter on cytochrome P450 in microorganisms is
very lucid but not comprehensive enough in its theoretical
and practical significance. A contribution on steroid hydroxylases would also have been desirable. In this case it
would not have been necessary to devote a special chapter
to the not very meaningful NMR data and to the still less
promising biotechnological aspects.
Regardless of these well meant criticisms, this book remains the first comprehensive monograph on cytochrome
P450, if the 1978 publication of the same title by Sato and
Omura, which is around half the length, is overlooked. The
decision to buy the book is facilitated by the reasonable
price. Since the paper quality is not of the best and the
index still needs supplementing, it is to be hoped that a
second, improved edition is planned soon.
VoZker UIrich [NB 698 IE]
Fakultat fur Biologie
der Universitat Konstanz (FRG)
Methoden der Analytischen Chemie. Eine Einfiihrung. Band
2: Nachweis- und Bestimmungsmethoden, Teil 2. By R .
Bock. Verlag Chemie, Weinheim 1984. xi, 379 pp.,
bound, DM 188.00.-ISBN 3-527-25865-5
The book in question is the fourth and penultimate volume of a comprehensive and systematic account of the
methods and instrumentation of analytical chemistry.
After “Decomposition Methods in Inorganic and Organic
Chemistry” (1972), this general review of analytical methods, originally planned as a single volume by the author,
turned out to be like the mythical hydra. Volume 1 was
fully taken u p with an account of “Separation Methods”
(1975). “Methods of Detection and Determination” (Vol.
2) proved to be so comprehensive that it is now being published in three parts. The first part (1980) dealt with procedures that are based on a measurement of electromagnetic
radiation. The second part, considered here, describes analytical methods involving the measurement of electrical
values as well as those based on thermal effects and phase
changes. The subjects of the third part, now in preparation,
will include, inter alia, gravimetric, volumetric, and barometric analysis as well as analysis employing chemical
reactions.
The arrangement of the work as a whole shows that the
author has introduced order into the manifold results of
Angew. Chem. Int Ed. Engl 25 (1986) No. 3
analytical inventiveness; he reduces methods, instruments,
and variations with impressive names and confusing abbreviations to the fundamental physical phenomena on
which they are based.
Basically, an electrical measurement is the common
characteristic of potentiometry, coulometry, voltammetry,
chronopotentiometry, and amperometric and galvanic
analysis. Gas chromatographic detection that depends on
electrical conductivity (flame ionization detector, thermionic detector, photoionization detector) and fi absorption (electron capture detector and helium detector) are
also mentioned in this context. Scintillation measurements
are dealt with under this heading as are fi-backscattering
methods, electron diffraction, electron spectroscopy (electron spectroscopy for chemical analysis, ultraviolet photoelectron spectroscopy, Auger electron spectroscopy,
electron impact spectroscopy), and the variants of mass
spectrometry.
These methods are described in varying depth according
to their significance. Under thermochemical methods, besides differential thermal analysis (DTA) and differential
scanning calorimetry (DSC), calorimetry/enthalpimetry
and the measurement of heats of adsorption and thermal
conductivity are dealt with in adequate detail. The final
chapter is devoted to methods involving phase changes:
turbidity, micellar and solution titrations, the determination of salting-out curves and the precipitation curves of
polymers as well as phase solubility analysis.
The reader repetitively experiences the feeling that “the
penny has dropped” when he realizes that very different
procedures are based on similar physical principles-and
this is quite a desirable effect from the educational point
of view. The arrangement of the book facilitates understanding and learning. The section on “electrical” methods
is preceded by a chapter dealing with the fundamentals of
electronics (from ampere to operational amplifier). The descriptions of methods are arranged clearly; a historical
summary is often appended. Areas of application and the
possibilities of error are critically indicated. Without losing
sight of the significant, an abundance of information is introduced in tables, sketches and diagrams. The text remains readable thanks to the consciously frugal use of abbreviations. Numerous clear examples make plain the
practical applications of analytical work. Each chapter is
accompanied by a carefully selected and organized literature section, which enables quick access to original literature.
“Methods of Analytical Chemistry” will be much appreciated as a German language textbook by advanced students of analytical chemistry. For those working in the
field, it may serve as a reference work designed to deepen
their knowledge, and will be of particular use when a general index will be available with the final volume.
Jiirgen Auffurth [NB 693 IE]
Bundesanstalt fur Arbeitsschutz,
Dortmund (FRG)
Reactive Molecules. The Neutral Reactive Intermediates in
Organic Chemistry. By C. Wentrup. Wiley, Chichester
1984. xi, 333 pp., bound, L 33.20.--ISBN 0-471-87639-9
Professor Wentrup’s book provides a delightful and authoritative survey of the chemistry of neutral organic reaction intermediates. After a lucid presentation of basic notions concerning reaction kinetics, thermochemistry, and
frontier MO theory in Chapter 1, the author discusses the
Angew. Chem Ini. Ed. Engl. 25 (1986) No. 3
various classes of highly reactive molecules in a very readable fashion: radicals in Chapter 2, biradicals in Chapter
3, carbenes and nitrenes in Chapter 4, strained ring compounds in Chapter 5, and cyclobutadienes in Chapter 6.
The section on radicals, which includes an introduction to
the use of ESR and CIDNP, and the section on the chemistry of carbenes and nitrenes, which is especially well
done, are about three times the length of the others.
Throughout, the emphasis is on chemical reactivity rather
than the details of matrix-isolation or transient spectroscopy. Indeed, some of the reactive intermediates have only
been characterized by trapping reactions so far. Each
chapter concludes with a useful set of problems, including
information permitting the reader to consult the original
literature to check the answers.
The text contains a number of useful tables and up-todate references. Those given in Chapter 1 are primarily to
monographs and reviews, those given in Chapters 2-6 are
mostly to original literature. They number from about fifty
to well over two hundred per chapter. References to specialized monographs, at least one of which exists for every
chapter, are also provided and will be useful to readers
seeking in-depth information.
In spite of its general excellence, the book does contain
a few errors. Some are trivial and barely worth mentioning,
such as ‘‘AHO(sub1) for styrene” on p. 5, which should read
“for stilbene”, or the presence of charge on formula 161
on p. 113, which is not compatible with the rest of the
equation, as well as the overabundance of hyphens, the
only clue which gives away the author’s continental background (as in “in the gas-phase”).
A few other errors are more likely to mislead a novice.
The equation for u N ,on p. 38 does not make it clear that
spin densities on the neighboring atoms as well as that on
the atom i need to be considered; on p. 88 one might get
the impression that a more exothermic reaction is always
faster; on p. 110 the relation of LUMO energies to electron
affinities as determined from electron transmission spectroscopy and electron photodetachment spectroscopy
could have been included in addition to the mention of UV
spectroscopy (whose use for the determination of LUMO
energies is not straightforward); on p. 128 and 129 transition states are referred to as maxima rather than saddle
points on surfaces; on p. 163 S, is a singly excited and Sz a
doubly excited configuration; the arguments offered to account for the inaccessibility of the cyclobutadiene dianion
on p. 312 could be applied equally well to the easily accessible cyclooctatetratene dianion.
It should also be noted that the correlation energy of
two electrons is not the energy required to bring them into
the same orbital (p. 163, 176), that the “heavy atom effect”
normally does not refer to the mass of the collision partner
in collision-induced intersystem crossing (p. 183), that the
internal bond of a propellane does not tend to have a zero
electron density (p. 299), and that a triplet ground state is
not expected for square cyclobutadiene (p. 3 I0,3 16; cf. dynamic spin polarization). Finally, although the occurrence
of rapid tunneling between the two rectangular forms of
cyclobutadiene may eventually indeed be excluded by
photoorientation results as claimed on p. 319, our experiments are still underway and until the final verdict is in, a
conclusion is premature (Ref. 34c does not exist).
All of the shortcomings I noted above are of a theoretical or physicochemical nature and somewhat peripheral to
the main subject of the book, which is treated in a very
nice manner. For those interested in the preparation and
chemical properties of the uncharged reactive interme295
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