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Book Review Organic Chemistry in Action. The Design of Organic Synthesis. (Series Studies in Organic Chemistry 41). By F. Serratosa

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special topics is a very good idea, even though it is not ideally
placed in the book. In their efforts to convey their special
interests the authors of the individual articles have tended to
neglect the treatment of the fundamentals, and they often
assume that the reader has an extensive knowledge of colloid
chemistry. In many cases it is difficult to relate the individual
contributions to each other, especially as their subject matter
is not always well harmonized: many points are explained
several times, others not at all, so that parts of the book are
quite laborious to read. Also some expressions are used with
different meanings in different chapters, and no consistent
notation is used for the mathematical equations.
One has a general impression that the proofreading has
been rather perfunctory. Often one comes across errors that
might be excused as mere blemishes in the main text, but
which cause problems when they occur in keywords (e.g.
“Stibene” frequently instead of “Stilbene”) or in literature
references. There are other minor errors which cause annoyance, such as missing chapter numbers (which frustrate the
laudable attempts of some of the authors to refer to “Chapter X” by one of the others), or gaps in the subject index: for
example, one searches in vain for “NMR” under the letter
N-instead it appears under R with just one entry (!) as
“Reversed micelle, NMR in”.
Despite its shortcomings the book can definitely be recommended as a source of more advanced information on the
field of reverse micelles, not least because of its references to
recent literature for further reading. However, as a first introduction to this field the book is of only limited suitability.
Some of the many review articles that are available on this
subject offer better introductions.
AndrP Laschewsky [NB 1090 IE]
Institut fur Organische Chemie
der Universitat Mainz (FRG)
finding strategic bonds are nicely introduced using patchouli
alcohol as an example. This part concludes with a discussion
of how to achieve stereochemical control in ring and acyclic
systems. In Chapter 9 on diastereoselectivity in reactions of
acyclic compounds, several variations of the aldol reaction
are treated followed by a short overview on Sharpless epoxidation. A recapitulation of the heuristic rules and their application, illustrated by a series of examples taken from the
literature, forms the third part, which concludes the main
text. The last part is unfortunately arranged in a rather fragmented way, consisting of Chapter 11, Appendices 2 to 4,
and the diskette containing a copy of the program CHAOS
(Computerisation and Heuristics Applied to Organic Synthesis). Appendix 2 is a tutorial for the use of CHAOS. In
addition there is a list of the retrosynthetic steps used by
CHAOS and some suggestions for exercises. Chapter 11,
which is a description of CHAOS, fits uneasily into the
book’s text.
To try to combine a textbook on organic synthesis and
planning with a computer program is certainly a good idea.
Unfortunately the present publication cannot be considered
to be a good combination of the two media. The program is
not polished enough to be a valuable help in the learning
process. CHAOS certainly cannot be used as an alternative
to other synthesis programs or reaction data bases. Looking
at the price the purchase of this book can only be recommended for libraries or for lecturers preparing courses on
organic synthesis. It only can be hoped that a much cheaper
version without the diskette will appear soon, thus enabling
students to profit from the nicely chosen examples; at the
same time the numerous printing mistakes could be eliminated.
Reinhard Neier [NB 1127 IE]
Institut fur Organische Chemie
der Universitat Fribourg (Switzerland)
Organic Chemistry in Action. The Design of Organic Synthesis. (Series: Studies in Organic Chemistry 41). By R Serratosa. Elsevier, Amsterdam 1990. xxi, 395 pp., hardcover
HFI. 290.00.--ISBN 0-444-88345-2
EPR of Exchange Coupled Systems. By A. Bencini and D.
Gatteschi. Springer, Berlin 1990. x, 287 pp., hardcover
DM 178.00.-ISBN 3-540-50944-6
Synthesis is still the main occupation of many organic
chemists. The systematic development of retrosynthesis by
Corey has contributed to the “renaissance” of synthetic
chemistry as a whole. The large number of recently published
natural products syntheses are a lively proof of this fact. In
spite of the large efforts in synthesis relatively few books are
available to introduce synthesis and synthesis planning to
students. The book “Organic Chemistry in Action” by R
Serratosa together with a copy of the program CHAOS aims
to provide such an introduction to organic synthesis. The
combination of a book with a computer program is new and
should hopefully facilitate the learning process for beginners.
Serratosa’s book can be divided into four parts. Chapters
1 to 4 present the basic concepts of synthesis planning. After
a short introduction to the history of synthesis the criteria for
evaluating synthetic schemes are introduced. The next chapter treats the systematic analysis of reactivity according to
Evans. A short introduction to retrosynthesis follows. In the
second part specific synthetic problems are treated. The first
problem is the synthesis of “dissonant” systems or, according to Seebach’s more familiar nomenclature, the application
of the “Umpolung” concept. Next a series of synthetic methods for synthesizing rings are presented. Strategies for synthesizing structures with quaternary carbon atoms and
bridged systems are described in Chapter 7. Corey’s rules for
This book is concerned with the theory of electron paramagnetic resonance spectroscopy (EPR) and magnetic properties for systems containing two or more magnetically coupled paramagnetic centers (transition metal ions and/or free
radicals). A knowledge of the basic theory of EPR spectra of
isolated centers is an essential prerequisite for understanding
this monograph.
After discussing the exchange and superexchange interaction mechanisms, including an explanation of the empirical
rules established by Goodenough and Kanarnori for the occurrence of ferromagnetic and antiferromagnetic exchange
in magnetically coupled systems, the authors discuss in detail
the spin Hamiltonian operator for such systems. Chapter 3
then deals with the spin levels and EPR spectra of magnetically coupled pairs and their dependence on the exchange
interaction. The spin Hamiltonian operators of the isolated
centers and the interaction operator are then used as the
basis for deviving the spin Hamiltonian operator for the
coupled system, by using irreducible tensor operators. From
this one obtains the relationship between the parameters in
the spin Hamiltonian for the individual centers (g-tensor,
fine structure tensor D and hyperfine structure tensor A ) and
those for the coupled system. Following this, the spin Hamiltonian operators and EPR spectra of clusters of paramagnetic species are analyzed, with the emphasis on treating systems
with strong exchange interactions (triads and tetrads). For
340
0 VCH
VrrlugsgesellsehurjtmbH, W-6940 Weinheim, 1991
0570-083319ijO303-0340 $3.50t .2S/O
Angew. Chem. Int. Ed. Engl. 30 (1991) No. 3
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