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Book Review Organic ChemistryЧin Color and Good The Chemistry of the Metal-Carbon Bond. Vol. 4 The Use of Organometallic Compounds in Organic Synthesis. Edited by F. R

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the subject will undoubtedly be keen to have review articles by experts to lean on, and on which they can rely (!).
In Aduances in Electrophoresis, a “balanced mixture” of
review articles is to appear, dealing with both methods and
applications. From this point of view Volume 1 is a good
beginning, with contributions from M . J . Dunn: “Twodimensional polyacrylamide gel electrophoresis” (109
pages, 587 references); C . R. Merril: “Detection of proteins separated by electrophoresis” (28 pp., 98 references);
J. M . Gershoni: “Protein blotting: a tool for the analytical
biochemist” (32 pp., 148 references); Nancy C. Stellwagen:
“Electrophoresis of DNA in agarose and polyacrylamide
gels” (49 pp., 155 references); K . Tukeo: “Affinity electrophoresis” (48 pp., 207 references); P. Gebauer, V. Dolnik,
M . Demel and P. BoEek: “Recent trends in capillary isotachophoresis” (76 pp., 239 references); R. Horuk: “Preparative polyacrylamide gel electrophoresis of proteins” (1 7
pp., 30 references); J. S. Surtonr “Red cell enzyme markers
in forensic science: methods of separation and some important applications” (46 pp., 141 references). The index,
so important for a book of this sort, contains ca. 1000 entries (1 1 pp.), and is therefore adequate for practical use.
The numerous, well-reproduced figures and tables are informative throughout.
All in all, the idea of this series as a collection of review
articles on various aspects of electrophoresis is a promising one, though the beginning is somewhat clumsy. DM
154.00 is a princely price, for which the editors are of
course not responsible; however, with the good presentation overall (and a Coomassie-blue colored band at its
head!), it seems justified.
Volker Neuhoff [NB 902 IE]
Max-Planck Institut fur experimentelle Medizin,
Gottingen (FRG)
Protein Engineering. Edited by D . L. Oxender and C. F.
Fox. Alan R. Liss, New York 1987. xvii, 365 pp., bound,
$36.00.-ISBN 0-8451-4300-X
This book, consisting of 30 separate articles, provides
the reader with an excellent survey of theoretical and practical aspects of protein structure and stability, and the effects obtained by introducing structural modifications. Our
present understanding of structure-activity relationships is
mainly based on protein structure determinations by X-ray
analysis and (more recently) by high resolution NMR
spectroscopy. These two techniques are treated in the first
section of the book, which also includes a chapter on the
possibilities for theoretically predicting structural modifications produced by mutagenesis. The section which follows consists of seven articles, which on the one hand describe techniques for mutagenesis and for isolating recombinant and mutant proteins, and on the other hand indicate the possibilities for using suitably modified proteins
to investigate the principles of protein chain folding and
structure. The third section deals, in nine articles, with basic aspects of the structure and stability of proteins in aqueous solution. Several articles are devoted to the hydrophobic effect, hydrogen bonding and amphiphilic structures, and their fundamental importance to stability and
chain folding of proteins is clearly explained, taking account of the most up to date views. Other articles in this
section describe the application of these principles to peptidomimetics and protein design, e.g. in synthesizing artificial amphiphilic oligopeptides with calcitonic activity. The
1110
final section of the book contains eleven articles describing, for example, experiments on regiospecific mutagenesis of individual proteins. These articles have two
main objectives: on the one hand to extend understanding
of the principles underlying the stability of the native form
of a protein with its specific chain folding, and on the
other hand to clarify the mechanism of enzymic activity at
the molecular level.
This book is an excellent introduction to “protein engineering’’. The individual articles are, without exception,
written by acknowledged experts in their fields. They are
well coordinated, and cover in appropriate detail all the
important aspects of this area of research. Where there is a
small amount of overlapping, as is necessary for a coherent
treatment of the topics, this is not a serious drawback, and
it is not usually possible to avoid it completely in a collection of individual articles. Detailed descriptions of particular techniques have been deliberately omitted in favor of
stressing fundamental principles and experimental procedures of general validity. The adoption of this philosophy
will ensure that, even several years hence, this book will
not have become much out of date. It is intended mainly
for advanced students and non-specialists. Nevertheless, it
is undoubtedly also of great value to the expert, whether
his background is in biochemistry, biophysics or genetics.
Finally, the price of $36.00 makes the book attractive.
Franz X . Schmid [NB 893 IE]
Institut fur Biophysik und Biophysikalische Chemie
der Universitat Regensburg (FRG)
The Chemistry of the Metal-Carbon Bond. Vol. 4: The Use
of Organometailic Compounds in Organic Synthesis.
Edited by F. R. Hartley. Wiley, Chichester 1987. xiv,
1349 pp., bound, $420.00.--ISBN 0-471-90888-6
This is (provisionally) the final volume in the series
“The Chemistry of the MetalLCarbon Bond”, and is aimed
primarily at the organic chemist. A clear-cut distinction
from Volumes 2 (“The Nature and Cleavage of CarbonMetal Bonds”) and 3 (“Carbon-Carbon Bond Formation
using Organometallic Compounds”) is not discernible, and
according to the editor was also not intended. Those who
are interested in the reactivity of organometallic compounds and also wish to use them in organic synthesis
would therefore do well to consult not only the present
Volume 4, but also Volumes 2 and 3, in order (hopefully)
to find what they require.
The contents are divided into two parts, approximately
equal in their coverage. The first is concerned with the preparation of main-group metal compounds, and their use in
organic synthesis. The first two chapters, on organo-alkali
metals (mainly Li; 157 pp., 1247 references) and organoalkaline earth metals (mainly Mg; 148 pp., 539 references)
therefore have a broad field to cover, as might be expected.
In this section particularly, the material is often presented
in tabular form, which undoubtedly makes an overview
easier to obtain. Chapters 3-6 are devoted to the synthesis
and uses of organoboranes (102 pp., 625 references), organo-aluminum compounds (62 pp., 281 references), organothallium(II1) compounds (66 pp., 325 references) and organo-silicon compounds (82 pp., 455 references). In general,
the literature is surveyed up to 1984, and so here too it
struggles along behind the year of publication, though not
so glaringly as in some chapters of the previous volumes. It
is not obvious why organo-tin compounds, which are beAngew. Chem. Int. Ed. Engl. 27 (1988) No. 8
coming more and more important for organic synthesis,
are not treated in conjunction with the analogous silicon
compounds, but quite separately, in volume 3. This would
certainly have been a help in demonstrating the advantages
and disadvantages of the use of the two classes of compounds.
Part 2 is devoted exclusively to the use (not the preparation) of certain families of organo-transition metal compounds. Fortunately the individual chapters were almost
without exception written by very competent authors,
which has been of very great benefit to the quality. The
first chapter deals with organo-iron compounds (107 pp.,
303 references), and makes brief mention of their significance as electron-transfer catalysts. There is some overlap
here with the later chapter on the use of transition metalstabilized carbocations (90 pp., 151 references), but this is
acceptable. Between the two lie expositions of organometallic complexes of rhodium (86 pp., 551 references) and
nickel (69 pp., 363 references); here too, some overlap with
individual chapters of Volume 3 can be discerned. Chapters I 1 (“Hydrogenation”, 69 pp., 665 references) and 12
(“Mechanism of homogeneous hydrogenation”, 23 pp., 90
references) are devoted to the use of organometallic compounds as hydrogenation catalysts, in which it is not only
homogeneous and heterogeneous hydrogenations with Hz
that are discussed, but also catalytic hydrogen transfer,
and-though only briefly-enantioselective
hydrogenations with the aid of chiral metal complexes. The final
chapter deals with the activation of C-H bonds in saturated hydrocarbons, including considerations of biochemical aspects (88 pp., 295 references) and of the fixation of
catalytically active organometallic compounds onto oxide
and metal supports (62 pp., 479 references). The volume
ends with a detailed author index, and a rather less detailed subject index. Whether a continuation volume will
follow, to fill the gaps that still exist at the moment, seems
to be undecided at present.
Collecting the material presented up till now must have
been a herculean task, and the editors earn great respect
for it. Apart from the arrangement of the individual chapters, which is not always successful, the presentation of results is almost without exception very effective. It is not
only the price, however, that stands in the way of the distribution of this four-volume work, but also the fact that
the even more comprehensive work “Comprehensive Organometallic Chemistry” appeared shortly before it.
Whether HartleyIPatai can compete with this remains to
be seen.
Helmut Werner [NB 903 IE]
Institut fur Anorganische Chemie
der Universitat Wurzburg (FRG)
The Chemistry of the Actinide Elements. 2nd Edition.
Edited by J. J. Katz, G . T. Seaborg, and L. R . Morss.
Chapman and Hall, London 1986. Volume 1: xii, pp.
1-886, bound. Volume 2: xii, pp. 887-1674, bound.
Price per volume L 95.00.--ISBN 0-412-10550-0 and
0-412-27370-5
The first edition preceding this two-volume work (published in 1957 and authored by J. J. Katz and G. T. Seaborg only) dates from the pioneering years of research on
the transuranium elements and has since then become by
far the best known textbook on the chemistry of the actinide elements. Thirty years ago, not only was the final eleAngew Chem. Int. Ed. Engl. 27 (1988) No. 8
ment of the actinide series (in the sense of Seaborg’s now
well-established “actinide hypothesis”) missing, but also
the existence of the preceding element, nobelium, had not
yet been fully confirmed. Now, however, in addition to No
and Lr, the transactinides with atomic numbers 104 to 110
have also been made. The new edition, notwithstanding its
unaltered title, includes not only the 15 elements AC to Lr
but all the translawrencium elements as well.
Without considering the elements Ac, Th, Pa and U
(which together account for 430 pages of the present
work), C. Keller had still managed in 1971 to describe the
chemistry of the transuranium elements in a single volume
of 675 pages. Obviously the progress which has taken
place in almost every sector of actinide chemistry has necessitated a restructuring of the old KatdSeaborg version
(506 pages), into a well-composed collection of 24 chapters
written by 33 acknowledged experts from the USA and
Western Europe. One of the four European authors is the
late Fritz Weigel (of the University of Munich).
The very comprehensive division of the material into
Part I, which is a systematic description of the individual
elements, and Part I1 which is focusing on specific properties and classes of compounds, respectively, of all the actinides, not only follows the structure of Keller’s book, but
is already discernible in the 1st Edition. The three editors
have themselves written the historically oriented introduction (Chapter 1, 11 pages), along with several other chapters, including one of particular versatility (Chapter 14, 74
pages: Summary and Comparative Aspects of the Actinides). This chapter is intended to be an introduction to Part
11, and contains short sub-sections on such varied topics as
naturally occurring transuranium elements, superconductivity, oxidation states, organometallic compounds, nuclear reactor wastes, biological effects, and the toxicology
of actinide compounds. For non-specialists Chapter 14
might in fact serve as a guide to other parts of both volumes.
More than half of Part I is occupied by Chapters 5
(uranium, 274 pages, by F. Weigel) and 7 (plutonium, 388
pages, by F. Weigel, J. J. Katz, and G . T. Seaborg). These
chapters deal in great detail with aspects of high importance for nuclear technology, e.g. the extraction of uranium and plutonium, and chemical reprocessing of nuclear
fuels. Separation techniques are described in this chapter
too, and are also treated in detail in chapter 21. Some compilations of data in the form of tables extending over several pages, e.g. on structural parameters of selected intermetallic uranium compounds (pages 235 to 241), are perhaps out of place in a book which is intended to also attract a non-specialist readership. The transeinsteinium elements, with atomic numbers 100 to 109, are treated collectively in Chapter 13 (by R . J. Silva. 32 pages), while the final chapter (Chapter 24, by G. T. Seaborg and 0 . L. Keiler,
Jr., 25 pages), is devoted to “elements of the future”, including the so-called superheavy elements.
Organoactinide chemistry, which was virtually non-existent in 1957, is here given considerable space, mainly in
Part 11. For some reason the authors of Chapter 22 (T. J.
Marks and A . Streitwieser) and Chapter 23 (T. J . Marks),
focus mainly on the 82 pages of these two chapters, on selected, and probably exemplaric, aspects of thorium and
uranium chemistry. However, chapters 3, 5, 7, 14, 18, and
20 also each include several pages on organometallic compounds, and some transuranium elements finally feature
here. Quite a lot of repetition has crept in here, e.g. on
page 368, as a consequence of the renaming of ally1 complexes to “allenyl complexes”. Other instances of overlap1111
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