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Book Review Organic Synthesis. Concepts Methods Starting Materials. By J. Fuhrhop and G

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Chemie der Raucherung. By L. Toth. A publication of the
Deutsche Forschungsgemeinschaft. Verlag Chemie,
Weinheim 1982. xi, 331 pp., stitched, D M 68.00.
This monograph provides a comprehensive 100-page literature survey of the smoking of foods (smoke production,
manufacture of smoke condensates, composition of the
curing smoke, the effects of smoking). Then follows a discussion by the author of the investigations of the phenol
fraction of curing smoke (ca. 140 p.) that he carried out at
the Bundesanstalt fur Fleischforschung at Kulmbach (production and condensation of curing smoke, analysis of the
phenol extracts, the influence of the smoking technique o n
the composition of the phenol fraction, phenols in smoke
essences and smoke flavors, phenols in smoked meat products).
Then follows an experimental portion (ca. 25 p.), a list of
all the smoke components so far described, classified according to compound type (306 compounds on ca. 50 p.)
and a bibliography (147 references).
This book is an excellent source of information for every
type of chemical and technological question cqncerning
the smoking of food and hence a solid basis for toxicological discussions. It belongs in every relevant library.
Hans-Dieter Belitz [NB 630 IE]
Institut fur Lebensmittelchemie
der Technischen Universitat Miinchen (FRG)
Computeranwendungen in der Chemie. By K . Ebert and H.
Ederer. Verlag Chemie, Weinheim 1983. ix, 359 pp.,
bound, DM 63.00.
Almost every scientifically definable field requires the
participation of another on many occasions. Classically
these are spoken of as auxiliary sciences, a phrase that
sounds somewhat condescending and is often meant to be
so. If a scientist combines this auxiliary science intensively
with his original field, he is often treated as an outsider
and may become an object of amusement. However, it can
happen that what was once an auxiliary science penetrates
large portions of the original and transforms it. Amongst
the natural sciences one only needs to mention the thrust
of mathematics into physics, and chemistry into biology.
Recently mathematics, information science, and computer
science have been extending their role within chemistry.
Theoretical chemistry without mathematics and high performance instrumental analysis (FT-IR, GC-MS, FT-NMR
etc.) without data processing are unthinkable. But techniques of instrumental analysis that are now regarded as
being classical (IR, UV, G C etc.) have also been conquered
by information science and data processing since the application of microprocessors. Nevertheless, the university
education of German chemists takes but slight account of
these trends. This gap has to be filled at the moment by the
further education program of the GDCh (German Chemical Society).
This present book is aimed at filling just this gap. The
hurdle of learning a high level programming language (in
this case BASIC) is skillfully bypassed. Using simple
chemically oriented examples a didactically very clever introduction is presented to the programming of personal
computers. The exemplary programs are concisely and
clearly constructed: commentary, input, calculation and
output. They are written using the minimum of BASIC
which is available with the cheapest personal computer.
144
However, in certain cases reference to more capable computers would have been sensible; even though they seem
costly, programming time would have been saved.
The severity of both the problems treated and the programming technique has been chosen in a didactically very
refined manner. Numerical integration, equations, linear
systems, differential equations, and nonlinear systems are
treated. In some cases a somewhat more critical presentation of the mathematics would have been desirable. Examples are numerical problems in matrix inversion or the
problem of the linearization of measured data (it is treated
using the Arrhenius equation). In other cases (e.g. Fourier
series) a more detailed presentation of the problem would
have been very useful in the book.
This book can be recommended to every chemistry student as a textbook and a book to work through, as an introduction to personal computers. The simple utilization of
the programs is not to be recommended since it is without
didactic worth. It would be even more senseless, for those
who wish to learn, to purchase the programs ready for use
as diskettes or tapes. The undeniable virtue of this book
lies in the fact that it offers the possibility of familiarizing
oneself independently with the fascinating world of small
computers.
J. Hocke [NB 632 IE]
Institut fur Pharmazie und-Lebensmittelchemie der
Universitat Marburg (FRG)
Organic Synthesis. Concepts, Methods, Starting Materials.
By J. Fuhrhop and G . Penzlin. Verlag Chemie, Weinheim
1983. xi, 355 pp., bound, D M 78.00.
With the increasing importance of chemical synthesis,
the problems of synthesis planning and execution have become focuses of interest. The number of recently published
books, dealing with the strategy and techniques of synthesis, mirror this development. This book is intended to provide advanced students and research chemists with knowledge of educts, target molecules and the concepts and
methods concerning their transformation.
The first chapter deals with the construction of carbon
chains and carbocycles, whereby the authors apply Corey’s synthon concept including the idea of “Umpolung” as
a useful heuristic principle. Here, as in many other publications, there is no strict differentiation between a synthon
as originally formulated by Corey and the reagents corresponding to this concept. It is inevitable that this point of
view-analysis of the target compound into synthonsshould lead to the neglect of one of the most important aspects of organic chemistry, namely stereochemistry.
The steric course of the reaction is then discussed using
individual examples. Some methods of carbon-carbon
bond formation, e.g. the Wittig reaction, are thoroughly
discussed mechanistically, at the same time drawing stereochemical conclusions. Just as thorough a discussion of
the aldol reaction would have been desirable, since, in its
many newly developed variations, it vividly demonstrates
the powerful nature of organic chemical synthesis.
The pattern is similar in the next chapter which deals
with the transformation of functional groups. The Sharpless epoxidation for the stereoselective synthesis of polyhydroxy compounds is amongst the omissions here; no account is taken of recent highly selective reducing agents or
microbiological reductions; some important protecting
Angew. Chem. Int. Ed. Engl. 23 (1984) No. 9
groups remain unmentioned although a special section is
devoted to them.
The third section returns to the subject of the first and
retrosynthetic analysis is undertaken of simple organic
compounds by use of the synthon concept. A comprehensive list of commercially available fine chemicals, which is
contained in the chapter, indicates to the reader how far
back the retrosynthesis must be taken.
The fourth chapter constitutes nearly half of the whole
work and presents the synthesis of particular compound
classes. Instead of developing the retrosynthetic discussion, begun in Chapter 3, at the level of more complex molecules an enormous range of synthetic examples has been
assembled and once again stereochemical problems are
only treated superficially.
In the chapter on steroids, the toys with which stereoselective syntheses were developed, a chance has been lost of
emphasizing the synthesis of pure enantiomers, in particular by the application of asymmetry-inducing synthetic
steps. The choice of other synthetic examples would have
easily made this possible. For the vitamin B12 syntheses,
which are attached to a section dealing with porphyrins,
chlorophyll a and corrins, the authors ought to have been
able to include examples concerning the strategies for the
solution of stereochemical problems alongside those dealing with the construction of the skeleton. The syntheses of
vitamin B12 are copybook examples in this respect. The
macrolide syntheses are another example that could be
cited, of which only one is mentioned. Here it would have
been possible to illustrate various synthesis strategies by
means of other examples. Since the macrolides were the
test bed for the development of stereoselective aldol reactions, this offered the possibility of renewed discussion of
the theme, which was introduced in the first chapter, at a
more advanced level.
The reader is confronted by a superfluity of examples
without the interrelationships being revealed. The authors
would have been well advised to discuss fewer examples in
terms of the synthon concept and to bring out the important stereochemical aspect by adept choice of the right examples of syntheses.
Franz-Peter Montforts [NB 621 IE]
Institut fur Organische Chemie
der Universitat Frankfurt am Main (FRG)
Dictionary of Chromatography. English-German-FrenchRussian. 2nd edition. Edited by H. P. Angele. Dr. Alfred
Huthig Verlag, Heidelberg 1984. 144 pp., bound, DM
54.00.-ISBN 3-7785-0926-8
Physikalische Chemie. Gesamtausgabe. 5th revised edition.
By G. M . Barrow. Friedr. Vieweg & Sohn, Wiesbaden
1984. xv, 941 pp., bound, DM SS.OO.-ISBN 5-52843806-1
Angewandte Statistik. Anwendung statistischer Methoden.
6th edition. By L. Sachs. Springer-Verlag, Heidelberg
1984. xxiv, 552 pp., stitched, DM 68.00.-ISBN 3-54012800-X
Advances in Chromatography. Vol. 23. Edited by J. Calvin
Giddings, E. Grushka, J. Cazes. and P. R . Brown. Marcel
Dekker, Basel 1984. xvi, 249 pp., bound, SFr. 140.00.ISBN 0-8247-7075-7
Physik und Erkenntnistheorie. By W. Pauli. Friedr. Vieweg
& Sohn, Wiesbaden 1984. xxvi, 198 pp., Paperback, DM
48.00.- ISBN 3-528-08563-0
Science and Technology. Vol. 5 and Vol. 6: Organic Coatings. Edited by G . D. Parfitt and A . V. Patsis. Marcel
Dekker, Basel 1984. Vol. 5: xi, 376 pp., bound, SFr.
198.00.--ISBN 0-8247-1905-0. Vol. 6: xi, 534 pp., bound,
SFr. 198.00.--ISBN 0-8247-7044-7
Special Publication No. 49: Challenges to Contemporary
Dairy Analytical Techniques. The Proceedings of a Seminar organized by the Food Chemistry Group of the
Royal Society of Chemistry in association with the International Dairy Federation, the Federation of European
Chemical Societies Working Party of Food Chemistry
(FECS Event No. 65), and the Association of Official
Analytical Chemists. The Royal Society of Chemistry,
London 1984. xi, 337 pp., Paperback, .€ 16.00.-ISBN 085 186-925-4
Polymer Chemistry: The Basic Concepts. By P. C . Hiemenz.
Marcel Dekker, Basel 1984. xi, 738 pp., bound, SFr.
97.00.--ISBN 0-8247-7082-X
Recent Advances in the Chemistry of Meat. Edited by A . J.
Bailey. The Royal Society of Chemistry, London 1984.
245 pp., Paperback, .€ 15.00 (reduction in price for members of the Royal Society of Chemistry).-ISBN 085 186-905-X
The Determination of Ionization Constants. A Laboratory
Manual. 3rd edition. By A . Albert and E. P. Seijeant.
Chapman and Hall, London 1984. x, 218 pp., bound,
E 15.00.-ISBN 0-412-24290-7
The Handbook of Environmental Chemistry. Edited by 0.
Hutzinger. Vol. 3, Part C : Anthropogenic Compounds.
Springer-Verlag, Heidelberg 1984. xiv, 220 pp., bound,
DM 138.00.-ISBN 3-540-13019-5
Adsorption on and Surface Chemistry of Hydroxyapatite.
Edited by D. N . Misra. Plenum Press, New York 1984.
viii, 179 pp., bound, $ 39.50.-ISBN 0-306-41556-X
Angew. Chem. Int. Ed. Engl. 23 (1984) No. 9
Chemistry for the Future. Proceedings of the 29th IUPAC
Congress, Cologne, Federal Republic of Germany, 510 June 1983. Edited by H . Grunewald. Pergamon Press,
Oxford 1984. xi, 449 pp., bound, ca. $ 95.00.-ISBN 008-029249-6
Annual Reports on Analytical Atomic Spectroscopy. Vol. 12.
Reviewing 1982. Edited by M . S . Cresser and L. Ebdon.
The Royal Society of Chemistry, London 1984. xii, 404
pp., bound, & 45.00 (Reduction in price for members of
the Royal Society of Chemistry); total price for vols.
3-12: f 213.00.--ISBN 0-85186-697-2
745
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