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Book Review Organisch-chemische experimentierkunst (Experimental organic chemistry) by C. Weygand and G. Hilgetag in collaboration with A

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compounds, and Chapter IV with coordination compounds.
The book closes with a list of over 1000 references, as well as
a subsbnce index and a subject index.
This book should be useful to anyone interested in the
application of I R spectroscopy to inorganic problems; it is
particularly suitable for use as a reference work.
W. A . Bingel
[NB 566 IE]
Chemistry and Cytochernistry of Nucleic Acids and Nuclear
Proteins. By G. Scholtissek et al. Vol. V/3 of “Protoplasmatologia”. Edited by M. A v e r t et al. Springer-Verlag,
Vienna-New York 1966. 1st Edit., iv, 236 pp., 67 figures,
paper D M 81.-; subscr. D M 65.-.
The book contains four independent articles: - C. Scholtiss e k : “The Chemistry and Biological Role of Nucleic Acids”
(47 pp.), B. M. Richards: “Cytochemistry of Nucleic Acids”
(34 pp.), R . and C. Vendrelv: “Biochemistry of Histones and
Protamines” (76 pp.), and D. P. Bloch: “Cytochemistry of
Histones” (51 pp.). These are good neviews with numerous
references. The first article presents the textbook knowledge
of the chemistry and functions of nuclejc acids, and goes
as far beyond this scope as is possible in 47 pages.
The other three artieles are more specialized; they are intended for those who wish to familiarize themselves with these
fields or who are looking for specific data and references.
However, one must ask who will look for articles of this
type in a “Handbook of Protoplasm Research”, which is
otherwise concerned with spherosomes, flagellae, vitamins,
frost resistance, etc. In raising this question, it is not intended
to cast doubt on the quality of any article, but only o n the
organization of the classical handbook system. However, the
volume can be bought separately, and it should not be absent
from the libraries of institutes concerned with these fields.
H. G. Zochau
[NB 576 IE]
Organisch-chemische Experimentierkunst (Experimental organic chemistry) by C. Weygnnd and G. Hilgetag, in
collaboration with A . Martini. Johann Amhrosius Barth
Verlag, Leiozig 1964. 3rd revised Edit., xxi\,, 11442 pp.,
213 figures, DM 65.20.
Tiiis book, which first appeared more than 25 years ago, is
now available i n a completely revised edition. The former
textbook has now become a reference work, the various
chapters of which have been written by specialists. The
arranbenient of the contents have remained unchanged, the
characteristic division into “bfaterials and Operations”,
“Reactions”, and “Chemical and Physical Characterization”
being retained. It was evidently again intended to provide a
comprchensive work, from which the user could learn all he
needed to prepare and characterize a product, in the order
corresponding to the course of an organic-chemical operation. The aims of the book have remained those of a textbook.
It suffers from the fact that the transition from a textbook to
a handbook has not been consistent.
The first part (113 pp.) contains useful information about
the most important chemical operations, particularly purifi.cation and separation processes. However, the treatment is
not sufficiently detailed for a handbook, and hardly goes
beyond that found in any good textbook of practical organic
chemistry. I t is essential t l d the next edition deal with ionexchange chromatography and zone melting. The section on
“Purification, Drying, and Testing of solvents” should
include tetrahydrofuran and refer to the use of molecular
sieves. The section on working with small quantities of
substances is well written. The survey of equipment and
apparatus is far from complete, and is also out of date in
places. No mention is made of equipment that has long been
regarded as indispensable. Users with access to other handbooks, sucb as Houben-Weyl-Miiller, will hardly look up
Weygand-Hilgetag on this topic.
3 80
The third part of the book (85 pp.) is of practically no value.
One might ask why, in a book intended for preparative
organic chemists, 44 pages are devoted to quantitative
analysis. Among other things, Ut7terznucher’s apparat us for
the determination of oxygen is described in detail. Quantitative analysis, apart fiom the determination of a few functional
groups, has long been a matter for the analytical specialist,
who will scarcely seek advice in this book. The contents of
the section on “Physical Characterization” are out of date.
By far the most important physical methods for the characterization of organic compounds, i.e. the spectrcscopic
methods, are dismissed in three pages. I R spectroscopy is
covered in 20 lines, and the 2 pages on UV spectroscopy are
of little interest to preparative organic chemists. NMR
spectroscopy, ESR spectroscopy, and mass spectroscopy are
not even mentioned.
The main part of the book (896 pp.) deals with synthetic
methods. Seventeen experts present a first-class survey of
old and new reactions. A concise and informative chapter
on organometallic compounds has been added. The reviewer
has profited from a study of this part of the book; he knows
of no single-volume work on preparative organic chemistry
that provides a comparable wealth of information. The fact
that a few methods have been omitted cannot detract from
the positive overall impression. However, the following
reactions should be included in the next edition: the HansleyPrelog and Stoll acyloin condensation, Cope elirniiration,
Hailer-Bauer cleavage, Baeyer-Villiger oxidation, alkykdtion
with Meerwein salts, the Bamford-Stevens reaction, the
Forster reaction, and the formation of cyclobutadiene rings
by cycloaddition. The value of the book is enhanced, and the
practical experience of the authors demonstrated, by numerous references to advantages and disadvantages of the
various processes and by many hints, e.g. on how to improve
the yields or how notoriously stubborn reactions can be
made t o “go”. The same is true of the more than 1200
“recipes”, which are skilfully selected for their relevance as
examples. Some 6000 carefully cited references enable the
reader to consult the original publicattons when necessary.
This part of the book unquestionably con?ains numerous
highlights. Unfortunately, many of these are not easy to
find. The reviewer doubts whether the arrangement according
to formation and cleavage of certain bonds is so well conceived as is asrurtcd in the preface. The full value of the
book will be enluyed oniy by the few readers who work
through it systematically like a textbook and then know
where to find any given piece of information. Anyone whose
theoretical knowledge I S so immense as to enable him to
plan his synthesis step by step on paper will also find the
book excellent, since it will offer examples for each step.
However, this will be true only if he is perfectly familiar
with the Weygand key, and so knows what reactions to look
for in chapters with headings such as “Formation of the
C - 0 Bond by Exchange with Formation of further C - 0
Bonds”. On the other hand, someone with no clear idea of
the synthetic rule to follow and the starting materials to use
will probably soon lay Weygand-Hilgetag aside and turn to
a handbook arranged according to the class of substance.
U. Schollkopf
[NB 565 IE]
Handbuch der Kolorimetrie. Band 111: Kolorirnetrie in der
Biologie, Biochemie und Medizin. 1. Organischer Teil.
(Manual of colorimetry, Vol. 111: Colorimetry in biology,
biochemistry, and medicine, 1. Organic section.) By
B. KnkaC and Z . J . Vejdc?lel.-. Translated by E. Ifnchova.
Gustav-Fischer-Verlag, Jena 1966, 1st Edit., xiii, 857 pp.,
77 figures. D M 74.-.
Volume I of this work[ll dealt with methods for the determination of substanccs of plant origin used in pharmacy by
light absorption in thz visible region. Similar methods for
synthetics and substanccs of animal origin were discassed
in Volume 11121. Volume 111 now deals with methods for the
determination of biochemically important substances. Long
Angew. Chem. internat. Edit.
Vol. 6 (1967) 1 No. 4
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