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Book Review Organized Multienzyme Systems Catalytic Properties. (Biotechnology and applied Biochemistry Series.) Edited by G. R. Welch

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is properly on the molybdenum chemistry, but the flavin
chemistry is presented as necessary. A good discussion is
presented of the problem of the oxidation-reduction potentials of the centers and whether they are in equilibrium
with each other. The last chapter, by M . Adurns and L.
Mortenson, discusses nitrate reductase and formate dehydrogenase. Here, there is less physical information on the
proteins and the sites and more discussion on physiology,
purification, and characterization.
The book is well printed, with only a few errors in
layout, such as misplaced figures in Chapter 2 and some
missing compound numbers in Chapter 1. This is a solid
addition to any library for those interested in the chemistry
of molybdenum in biological systems and related inorganic chemistry.
Scot Wherlund [NB 790 IE]
Washington State University
Pullman, WA (USA)
Organized Multienzyme Systems: Catalytic Properties.
(Biotechnology and applied Biochemistry Series.)
Edited by G . R. Welch. Academic Press, New York 1985.
xiii, 458 pp., bound, $! 75.00.--ISBN 0-12-744040-2
This monograph summarizes, mainly from a biochemical and biological viewpoint, the extraordinary wealth of
information which exists o n organized multienzyme systems. In each of the nine chapters an expert in the relevant
topic outlines its most important features, with examples.
The topics discussed include the fundamentals of protein
organisation in mitochondria, catalytic processes and energy transfer in membranes, dynamic compartmentalization of multienzyme complexes in the cytoplasm, questions
concerning the flexibility and co-operativity of enzyme
molecules in the kinetics and regulatory mechanism of allosteric enzymes, and reversible adsorption as a modulator
of enzymatic activity. Mechanistic models for sequential
enzymatic pathways are also proposed and discussed, and
detailed analyses of the kinetics of multienzyme systems
are given. The monograph concludes with a chapter on
long-range energy continua, and their role in the transfer
and conservation of chemical energy in multienzyme sequences, and thus in the regulation of metabolism.
Chapters on naturally occurring multienzyme sequences
are especially appropriate to the aims of this monograph,
in showing the mode of action and structural features of
organized multienzyme systems and the role of the microenvironment, together with a critical discussion of current
theoretical models. On the other hand, Chapter 7, on the
kinetic analysis of multienzyme systems in homogeneous
solutions, falls outside the proper scope of the book. Kinetic models for sequential reactions, some of which are
already well-known, are laboriously presented here in a
complicated and unconventional notation. The inclusion
of a lengthy and not very useful 13-page digression into
the use of the Laplace-Carson transformation to solve ordinary differential equations is quite incomprehensible.
Apart from the availability of numerical computation
methods nowadays, there i s no obvious advantage in using
such laborious integral transformations rather than conventional integration methods. Furthermore, the literature
referred to is not always truly representative; for example
the book by Ayres (1952) on the theory of differentia! equations is now hardly the most appropriate source on the
trivial solution of the differential equations for a first-order reaction. However, readers who are engaged in theoretical work or interested in these aspects will be compensated by the discussion in Chapter 8 on the behaviour of
immobilized multienzyme systems, particularly in membranes. Here we find a successful combined presentation
of experimental studies of diffusion-limited enzymic reactions together with the relevant theoretical models, using
mathematical techniques of a practical nature which are
described in a comprehensible way. Especially noteworthy
is the elegant theoretical modelling of the highly nonlinear
diffusion-limited reaction effects in multienzyme systems
with complex control mechanisms. A reading of this chapter will also be of value to all process-oriented biotechnologists. Elsewhere in the monograph, however, there are
many places where, although it is assumed that the knowledge presented will be of interest to biotechnologists, no
relevant cross-reference is included. Consequently those
involved in the practice of biotechnology may have difficulty in making use of the abundant fundamental knowledge displayed. The one chapter whose title mentions
practical applications (Chapter 6- Models of organized
multienzyme systems: use in microenvironmental characterization and in practical application) is comparatively
vague, and deals with the practical aspects in a mere five
pages. The main emphasis is on coenzyme regeneration,
but the discussion of coupled equilibria does not, unfortunately, include the latest developments which have been
reported, e.g. for the enzyme membrane reactor.
The monograph thus demonstrates the importance and
the difficulties of communication in interdisciplinary fields
of knowledge. The book can be recommended to all who
are concerned with setting up immobilized cells for bioconversions, as the results, concepts and theoretical models presented here are of considerable importance for
them. Because of the comparatively high price, only highly
specialized readers and those with theoretical interests will
wish to buy it for their private libraries.
Maria-Regina Kulu [NB 788 IE]
Institut fur Enzymtechnologie
der Universit3t Diisseldorf
at KFA Julich GmbH (FRG)
PIC used !n r h i s loeniol. evert when noi morhed os such. ore nor 10 he m,r.sidered wprore<!ed hi luu
cllwh;tft m h H . 13-6940 Weinhelm. 1987 - Printed rn the Federal Repuhlic of Germ‘tny hy Zechnersche Buchdruckerel. SpeyerIRheln
Reyimred tiuiwss.irrrdemorhs.
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