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Book Review Practice of High-Performance Liquid Chromatography. Edited by H. Engelhardt

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and their derivatives, in particular the highly toxic compound octafluoro-isobutene (LCs,,=0.5 ppm!).
The main subject of the second section, entitled
“Fluoroaromatic Compounds”, are the perfluoro-arenes,
on the basis of which the Novosibirsk research group led
by G. G. Yukobson has developed an extensive area of
chemistry, here described in a very expert fashion.
L. M . Yagupolski et al., of the Kiev laboratory of the
Soviet Academy of Sciences, have produced the third section on “Aromatic Compounds with Fluorinated Side
Chains”. The main type of fluorinated side chain dealt
with is the trifluoromethyl group. As one would expect, the
conversion of carboxyl groups into CF3 substituents using
SF, assumes an important role here, whereas only a few
examples of fluorine-chlorine exchange in the corresponding chlorinated starting materials using SbF3 are given, and
that using hydrogen fluoride is not mentioned at all.
This compilation of synthetic methods for organofluorine compounds is not only of interest to organofluorine
chemists in academic or industrial laboratories. It is also of
value to the preparative organic chemist, as the methods
have generally been chosen such that no special equipment
is needed to put them into practice; information is also
given in an introductory chapter concerning the toxicities
of the most important fluorinating agents and reactive
fluorine-containing products, together with advice on handling them.
The positive impression gained from the book as a
whole is somewhat diminished by an abnormally large
number of printing errors in the text and structural formulae, leaving the user with a feeling that, for whatever reason, careful correction of the proofs has been omitted.
Giinter Siegemund [NB 817 IEJ
Hoechst AG, Frankfurt am Main (FRG)
High-Performance Liquid Chromatography in Biochemistry.
Edited by A . Henschen, K.-P. Hupe, F. Lottspeich, and
W. Voelter. VCH Verlagsgesellschaft, Weinheim 1985.
xiii, 638 pp., bound, DM 198.00.--ISBN 3-527-26057-9
Practice of High-Performance Liquid Chromatography.
Edited by H . Engelhardr. Springer, Berlin 1986. xii, 461
pp., bound, DM 198.00.--ISBN 3-540-12589-2
Biochemical research is scarcely imaginable without the
use of chromatographic methods for analytical and preparative work, and the latest high performance versions have
vastly improved the precision and speed of separations
and the accuracy of quantitative analysis. The first of these
two books, which includes contributions from authors in
the German-speaking world, is of great interest to all who
work in this field, since, following the appearance of a
number of symposium volumes and one less successful attempt at the topic (Hancock and Sparrows: HPLC Analysis of Biological Compounds), we now have for the first
time a complete summary of the basic principles and scope
of applications to all the relevant classes of substances.
The book has as its introduction three chapters which
deal with the fundamentals of chromatography, the column as the heart of the chromatographic set-up, and the
remaining experimental requirements for analytical and
preparative work. The presentation of this material is relatively condensed, but is essentially adequate as a basis for
beginners. However, the instrumentation section really
does no more than list components, without discussing the
advantages and disadvantages of different arrangements.
A further group of articles deals with individual classes
of substances: amino acids, peptides and proteins, peptide
Anqen, Chem. Int
Ed. Engl 26 (1987) No. 7
hormones, biogenic amines, lipids, carbohydrates, nucleic
bases, nucleosides and nucleotides, porphyrins, steroidal
hormones, vitamins, organic acids, and substances present
in plant tissues. These articles contain many illustrations
and typical examples of separations, and details of columns and mobile phases that can be used, usually summarized in the form of tables with a more detailed discussion in the text. Information is also given on detection
problems and the optimized pre-treatment of the sample,
which in biological materials often includes an extraction
step. Unfortunately the details of the methods are not always collected together in a form which stands out clearly
from the text, in the way that they are set out in the example given for the section on porphyrins.
The subject index and bibliography are very comprehensive, though the literature cited extends only u p to 1981 in
some cases, and in no case later than 1982. Thus, as often
occurs in books of this kind, topicality has been sacrificed
in favor of keeping to a pristine appearance of the text, a
policy which one must sometimes feel to be a disadvantage
in such a fast changing field. This can be seen in the case
of proteins, where it has not been possible to take account
of the very extensive knowledge gained recently on retention mechanisms for biological macromolecules and on the
mechanisms and kinetics of denaturation in contact with
the carrier. The latter point is, in fact, of considerable importance, since it has now led to a shift of emphasis away
from reversed phases towards biocompatible systems (ion
exchange chromatography, hydrophobicity chromatography, and affinity chromatography).
However, despite the above shortcoming this is a book
which will deservedly become a standard work on the subject, and its purchase can be well recommended, even for
inclusion in one’s personal collection. Against the general
tendency to deal with ever narrower specialized topics, this
book brings together theoretical fundamentals and practical applications in a form which is suitable even for newcomers, and at the same time affords a look out beyond
one’s own “backyard fence”.
The title of the second book could easily lead to misunderstanding. This work, written through the collaboration
of an international team of authors, is definitely not intended as a general source of advice on HPLC laboratory
practice; instead it deals with a few selected aspects,
mainly of a practical nature, burdened with only a little
theory. Separation mechanisms are discussed in detail only
in two of the chapters, on liquid-liquid chromatography
and o n ion pair liquid chromatography. Other sections
which treat questions of general importance are those on
quantitative analysis, special requirements for high resolution preparative work, and sample preparation together
with methods for automating it. The chapter on column
switching techniques also includes discussions on pre-concentration from complex mixtures, and on the removal of
interfering substances before analysis. This group of topics
is introduced by a descriptive list of the various components available for HPLC systems, which is impressive in
its wide scope and completeness, including even automatic
control equipment and data recording (although columns
are not included!). The various ideas are not simply listed,
but are discussed.
The second half of the book is devoted to applications,
which include a wide variety of fields such as forensic
chemistry, the separation of lipids, analysis of natural and
synthetic drugs, analysis of psychotropic substances in
body fluids, HPLC of amino acids and proteins, the separation of nucleic acid metabolites present in physiological
fluids, and lastly the chromatography of coal and oil products. Careful editorial attention is apparent in this part of
the book too; for example, one feature deserving special
praise is that important steps in sample preparation and
preliminary separation into different types of substances
are always clearly emphasized, rather than being buried in
the rest of the text.
All the chapters are quite well balanced with regard to
length, although it is true that this can sometimes give
grounds for criticism. Thus, for example, three pages on
“HPLC of proteins” simply does not d o justice to the wide
range of applications that exists in this field of work. It
would have been more sensible here to limit the length of
the chapter by confining the discussion to amino acids.
Because of the rather arbitrary collection of topics
which it brings together, it is difficult to recommend this
very well produced book to a specific group of readers.
Many will at first be interested only in individual chapters,
and beginners in the field will regret the absence of chromatographic fundamentals. Consequently few readers will
consider it for their own bookshelves, but it certainly ought
not to be omitted from any library.
Gerhard Seipke [NB 798 IE]
Hoechst AG, Frankfurt am Main (FRG)
Science of Ceramic Chemical Processing. Edited by L. L.
Hench and D. R . Ulrich. John Wiley, New York 1986.
594 pp., bound, $ 90.30.--ISBN 0-471-82645-6
With the growing interest during recent years in new materials, especially in advanced ceramics, and the high expectations that are associated with them, their chemistry
has attracted an increasing amount of attention. This trend
is catered for by a series of international symposia entitled
“Ultrastructure Processing of Ceramics, Glasses and Composites”, held at two-yearly intervals since 1983. The papers of the second of these meetings (1985) are published
in this book, edited by Hench and Ulrich.
The title “Science of Ceramic Chemical Processing”
could easily mislead German-speaking readers, as the term
“ceramics” is used here in its broader sense to include also
glasses, a usage which differs from that of the German
“Keramik”. In fact fewer than half of the sixty papers are
concerned with technical ceramics in the narrower sense.
The majority deals instead with glasses, general colloid
chemistry, and organic polymers, some of those in the last
category having only a tenuous connection with ceramics.
It would be best to regard the papers presented here as
having the common theme of “Ultrastructure (chemical)
processing”. Ultrastructures, also referred to by some authors as “nanostructures”, can be taken to mean ordering
phenomena in solids with a scale of distances intermediate
between the Angstrom dimensions of molecular structures
and the micron dimensions typical for particulate structures. Essentially three main routes for the production of
such materials are discussed, namely the sol-gel technique,
the processing of colloidal particles with a well-defined
size distribution, and the conversion of covalent polymers,
e.g. polysiianes, polycarbosilanes and pofysilazanes. The
sol-gel technique received especially detailed coverage at
this meeting; the 35 papers on this topic dealt with both
the scientific basis of the technique and with its applications, but nevertheless one got the impression that the high
hopes that are held for this process have not yet been realized in practice. On p. 121 J . D. Mackenzie quite rightly
says that “The science of sol-gel processing is still in its
infancy at present”. The same is also true of the two other
routes mentioned above.
With regard to the book as a whole, the comments that
generally apply to books of conference proceedings are, of
course, also true here. The quality of the papers, and the
amount of care put into writing them, varies greatly from
author to author. A number of the articles have already
been published elsewhere, and there are many instances of
overlapping and repetition. Articles on highly specialized
topics are sometimes grouped together in an unrelated
fashion. The editors have succeeded in imposing a certain
amount of structure by dividing the book into six chapters:
Sol-gel science, Applications of sol-gel processing, Materials from organometallic precursors, Ultrastructure in macromolecular materials, Micromorphology science, and
Quantum chemistry. The presentation, the printing and the
quality of the illustrations are all good. The detailed subject index provided at the end of the book is also a welcome feature.
Despite the limitations mentioned, this book, in common with the preceding symposium volume (published in
1984), can be recommended to all those readers seeking a
review of the latest developments in this topical interdisciplinary field between chemistry, chemical engineering and
materials science.
M . Peuckerf [NB 821 IE]
Kerami kforschung,
Hoechst AG, Frankfurt am Main (FRG)
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Angew. Chem. Inr. Ed. Engl. 26 (1987) No. 7
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