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Book Review Progress in Drug Research Ц Fortschritte der Arzneimittelforschung Ц Progrs de recherches pharmaceutiques edit. by E

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Very pure trialkylindium compounds were prepared by E. Todt
and R . DStzer. They fused technical In (containing up to 5 %,
impurities) with technical Mg in an atmosphere of hydrogen.
Fine turnings of this alloy (or niixtures of In and Mg) were
covered with ether and treated with alkyl halides under a
blanket of specially purified nitrogen or argon.
After the reaction, the trialkylindium compounds can be
distilled off as etherates; a second distillation is usually sufficient to remove the ether. The etherate of trimethylindium can
be decomposed by distillation with a little benzene. Trimethylindium (1) forms colorless crystals (b.p. 66-67 OC/12 mm;
m.p. 88.4 “C) and is complelcly stable to light and heat, even
at 250 “C. The triethyl, tri-n-propyl, tri-isopropyl (2), tri-nbutyl, tri-isobutyl, and tri-s-butyl (3) derivatives of I n are
faintly viscous, colorless liquids; (2) and (3) are yellow. All
these compounds ignite spontaneously in air and react violently with water. With the exception of 1/),they are decomposed by light and by heating to 200”C, or less, the metal
being deposited. Indium purified in this manner is suitable
for the preparation of All1 I3v compounds for senii-conductors. / Z. anorg. allg. Chem. 3 2 / , 120, (1963) / -Kr.
[Rd 6081170 IE]
BOOK REVIEWS
German-English Chemical Terminology. An 1 ntroduction to
Chemistry in English and German, by H. Fromherz and
A . King. Verlag Chcmie GmbH., WeinheimIBergstr.
1963.4th Edit., XX1,588 pp.,linen, DM48:- (about$l2.--).
The ability to read chemical literature in a foreign language
i s now a necessity for students. Any knowledge of languages
brought from school, however, has not normally been acquired from scientific texts, and the specialised modes of expression of the latter are therefore often found very difficult
to understand. Here the “Introduction to Chemistry in
English and German” offers valuable help. The basic idea
of the book is as simple as it is fortunate. German and English texts are printed facing one another on adjacent pages,
each technical term is in italics, and page subdivision in
the margin facilitates orientation. The whole is a condensed
textbook of chemistry and its related subjects, concluding
with a list of abbreviations, a subject index in English, a guide
to the pronunciation of English technical terms, and a subject
index in German. The agreement between the German and
English phraseology in the text is good - except for a few
mistakes -, and as close as the style of each language permits.
In the choice of material and in its clear and compact presentation, the authors have found just as fortunate a touch as in
their translations of relevant sections into the other language.
Any chapter of the text may be selected and read on its own
and thus a feeling gained for modes of expression in English
and German scientific works. The book can also be used just
as well as a two-language dictionary - it has over 10000 terminological entries. It is this twofold function which makes
the volume so especially uscful for students, scientists, and
translators.
H . Grunewald [NB 26/52 IE]
Fortschritte der ArzneimittelProgress in Drug Research
forschung
Progrks de recherches pharmaceutiques, edit.
by E. Jucker, Vol. IV, Birkhauser, Basel-Stuttgart 1962.
1st Edit., 606 pp., bound, D M 118.-- (about $30.-).
The fourth volume of the series begun in 1949 [l] again
presents detailed reviews by expert authorities on current
problems in drug research. In the first 212 pages H . Herbsl
describes “New Developments in the Field of Therapeutic
Organic Sulfur Compounds.” The first section of the article
is devoted to sulfur-containing drugs and antibiotics, while
in the second, orgdnotrophically active organic sulfur compounds are dealt with. Besides the chemistry of the com-
pounds, the methods of synthesis of the most important
representatives are given, and the mechanism of action, fate
in the organism, and methods of detection are briefly mentioned; 1958 references to patents and journals give access to
the original articles.
N . J . Harper then describes “Drug Latentiation” in 74 pages.
This new term is used to describe the chemical modification
(in the laboratory) of a biologically active compound into an
inactive form which is transformed in vivo into the active
substance. The term also covers modifications simply of
physico-chemical properties that cause changes in resorption,
distribution, and metabolism of the compound in question
without influencing its activity. These transformations are
illustrated by numerous examples and can also stimulate
improvements of existing preparations with regard to resorption, compatibility, etc. (059 literature references).
In the next chapter (54 pages), E. Schlittler, J . Druey, and
A . Murxer report on “Antihypertensive Agents.” It is subdivided into sympatholytics, parasympatholytics, ganglion
blocking agents, hydrazinophthalazines, Ruuwolfiu alkaloids.
Veratrum alkaloids, guanidines and amidoximes, saluretics,
and other compounds. By giving numerous examples the connection between constitution and activity is also suggested
(191 literature references). The “Connection between Constitution and Activity in Local Anaesthetics” is treated in
47 pages by H . Crusshof: Starting out from the basic strucintcrmediate chains with an electure, lipophilic residue
tronegative link ~.hydrophilic residue, the influence of each
ofthese parts on the activity is described. Numerous examples
in 29 tables are an aid to easy understanding (121 references).
The last chapter by J . C. Arcos and M. Arcos deals with the
problem of “Molecular Geometry and Mechanisms of Action of Chemical Carcinogens” (174 pages). The major
portion is devoted to the relationship between structural
parameters and carcinogenic activity in the various groups
of carcinogenic compounds. Further sections deal with the
possible types of combination of carcinogens with tissue
constituents and finally with submicroscopic cell structures
(876 literature references).
The layout of the book is exemplary; numerous structural
formulae make the reading of it much easier. An especially
welcome feature is its 22-page comprehensive subject index
covering all the reports.
0. Schaumann
[NB 19/48 IE]
[ l ] Vols.11 and 111, cf.Angew. Chem. internat. Edit. 1,607 (1962).
Registered names, trademarks, etc. used in this journal, even without specific indication thereof, are not t o be considered unprotected by law.
0 1963 by Verlag Chemie, GmbH. - Printed in Germany by Druckerei Winter, Heidelberg.
All rights reserved. N o part of this journal may be reproduced in any form whatsoever, e . g . by photoprint, microfilm, or any other means, without
written permission from the publishers.
Editorial Office: Ziegelhauser Landstrasse 35, Heidelberg, Germany, Telephone 24975, Telex 04-61 855, Cable address: Chemieredaktion Heidelberg.
Chief Editor: W. Foerst Editors: F. Boschke and H . Grunewald.
Publishers: Verlag Chemie GmbH. (President Eduard Kreuahage), Pappelallee 3 , Weinheim/Bergstr., Germany, and Academic Press Inc. (President
Walrer J. Johnson), 11 1 Fifth Avenue, New York 3, N.Y., U.S.A., and Berkeley Square House, Berkeley Square, London, W. 1, England.
Correspondence concerning advertisements should be addressed toVerlag Chemie, GmbH. (Advertising Manager W.Thiel), Pappelallee 3, W e i n h e i d
Ilcrgstr., Germany, Telephone Weinheim 3635, Telex 04-65 516. Cable address: Chemieverlag Weinheimbergstr.
.
564
Angew. Chem. intrrnut. Edit. 1 Vol. 2 (1963) 1 No. 9
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