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Book Review Semisynthetic Proteins. By R. E. Offord

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Grundlagen der Kalorimetrie [Principles of Calorimetry]. By
W. Hemminger and G. Hohne. Verlag Chemie, Weinheim
1980. xiv, 256 pp., bound, DM 88.00.
In view of the fact that no book in the German language
dealing exclusively with calorimetry has appeared since W.
Roth and F. Becker’s monograph (1956), although the importance of this method of measurement has been increasing
continuously, the appearance of this book can only be welcomed.
The declared aim of this monograph is to provide information about the technical state of commercial apparatus and,
with the aid of examples, to encourage the application of calorimetric methods. Accordingly, the book is divided into
two parts, the first part being devoted to calorimetry and the
second to calorimeters. The first part is preceded by a clear
systematic classification of calorimeters subdivided according to the measurement principle, method of operation, and
type of construction. This introductory matter must be welcomed, since it assists in throwing light on the jungle of nomenclature used in publications both as regards calorimeters
themselves and the measurement principles. Other points of
emphasis in the first part are the descriptions of the instruments for recording the measurements and the presentation
of the thermodynamic principles, heat-transport phenomena,
and the ambient and operating conditions. Finally, the evaluation of the measured curves is discussed in full. The second part is devoted to historical and current commercial apparatus. It is clear that the fundamental ideas in the field of
calorimetry go back to such well-known workers as Bunsen
and Eucken, and it is not a criticism to report that descriptions of individual examples of special apparatus avaiiable
only to small research groups are not given.
The last section is intended to assist in the selection and
evaluation of the suitability of calorimeters. Here there are
some valuable pointers on the basis of which apparatus best
suited to the solution of particular problems can be selected.
The decision is helped by a list of addresses of the suppliers
and associations concerned.
The book does not assume any special knowledge and is
directed at practical research workers, advanced students,
and interested industrial workers. Detailed and comprehensive accounts of individual solutions to problems cannot,
therefore, be expected. However, for the group at which it is
aimed this book is recommended reading.
Horst Klump [NB 519 IE]
Semisynthetic Proteins. By R. E. Offord. John Wiley & Sons,
New York 1980. xi, 235 pp., bound, f 17.00.
Protein semisynthesis is the use of fragments of naturally
occurring proteins as easily available intermediates for building up proteins with new types of structures. If, for example,
it is desired to investigate the effect of a single amino acid on
the biological activity of a protein molecule, it is not necessary to build up the entire molecule step by step. Semisynthesis should always be considered in such cases if the molecular fragment to be replaced is located in a strategically favorable position of the amino-acid sequence, e.g. at the Nterminus; this end can be degraded stepwise, e. g. by the Edman method, and be replaced by acylation with suitable amino-acid and peptide derivatives (permutation). Offord is a
pioneer in protein semisynthesis, and the present monograph
summarizing his experience and that of his many friends and
associates is therefore highly welcome. In it he has succeeded
not only in presenting the theoretical principles of protein
semisynthesis clearly and critically, but also in greatly facilitating the entry of newcomers into this field with proven laboratory procedures. The book is divided into eight chapters:
Synthesis and Semisynthesis, Protecting Group Tactics for
Splitting off Fragments, Cleavage and Separation of Protein
Fragments, Protecting Group Tactics after Cleavage, Methods of Coupling, Cleavage of Protecting Groups and Purification, and Review of Published Papers on Protein Semisynthesis.
The book is most warmly recommended to biochemists,
molecular biologists, pharmacologists, and chemists who
wish to work in the field of protein semisynthesis.
Helmut Zahn [NB 521 IE]
Ullmanns Encyklopadie der technischen Chemie [Ullmann’s
Encyclopedia of Industrial Chemistry]. Edited by E. Burtholome, E. Biekert, H. Hellmann. H. Ley (deceased),
W: M . Wzegert (deceased), and E. Wezse. Vol. 18: Petrolsulfonate bis Plutonium [Petroleum Sulfonates to Plutonium].
Verlag Chemie, Weinheim 1979. 4th edit., xvi, 738 pp.,
bound, DM 475.00.
Another volume[’] of the new edition of Ullmann has arrived. Its most comprehensive entries are on Pharmaka
[Pharmaceuticalsj, Phosphor und seine Verbindungen (Phosphorus and its Compounds], Photographie [Photography],
and Pigmente [Pigments]; together they make up two-thirds
of the contents. The entry on Pharmaceuticals (107 pages)
begins with a general part which, in addition to an introductory section on the action of pharmaceuticals, deals with the
testing of drugs and the statutory regulations concerning
their registration and marketing. This is followed by special
entries on individual areas such as Antiepileptika [Antiepileptics], Kontrazeptiva [Contraceptives], Muskelrelaxantien
[Muscle Relaxants], and Psychopharmaka [Psychopharmaceuticals]; here it must be observed that other, more extensive, areas of pharmaceuticals, e.g. antibiotics or heart and
circulation agents, appear in other volumes under their own
entries in accordance with their positions in the alphabet.
Pharmazeutische Technologie [Pharmaceutical Technology]
(25 pp.), i.e. the science of preparation forms of drugs (liquids for injection, tablets, ointments, etc.), an important
field that is also known under the name of Galenik [Galenics], is also treated on its own. The entry on Photography
(102 pp.) treats photographic chemistry in the form of a
monograph, the processes of colour photography being illustrated in color. The Pigments entry (a total of 150 pp.) contains special sections on several inorganic and organic pigments, dealing not only with manufacturing processes but
also with applications and toxicology. Among other things, it
states that the world consumption of the most commonly
used white pigment, titanium dioxide, in 1976 was 1.85 x lo6
tons! Under Phosphorus and its Compounds (a total of 115
pp.) we find, besides elemental phosphorus, the phosphorus
oxides, phosphorus acids, and phosphates, as well as the other organic and inorganic phosphorus compounds. The present volume also includes entries on Platinmetalle [Platinum
Metals] and their compounds (32 pp.), Plutonium (10 pp.),
Cf. Angew. Chem. Int. Ed Engl. 19. 148 (1980).
Angew Chem. Int. Ed. EngI. I9 (1980) No. I0
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