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Book Review Solid Phase Peptide Synthesis. By J. M. Stewart and J. D. Young

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presented chapters dealing with methods of preparation,
properties, and reactions of organic compounds of metals of
the main groups and of the triads. In the chapter on catalytic
processes, insufficient attention is given to exchange and reorientation phenomena in intermediate complexes, i.e. the
dynamic aspects of the metal-catalyzed reactions. The reader
making his first contact with organometallic chemistry may
find the book difficult to read because of the large numbers
of individual facts mentioned in some sections.
P. Heimbach
[NB 826 IE]
Experimental Methods in Catalytic Research. By R. B.
Anderson. In the series “Physical Chemistry”. Academic
Press, New York-London 1968. 1st Edit., xii + 498 pp.,
numerous illustrations and tables, bound, $ 22.50.
In the past four decades methods have been developed for
studying the alteration to molecules activated on a catalyst
and the physicochemical properties required in a catalyst for
specific processes of heterogeneous catalysis. A series of such
experimental methods is described in this book. Since an
introduction into the theory and the experimental bases of
these methods requires very varied experience, R . B. Anderson has recruited several well-known scientists with special
experience to present the extensive material in eleven chapters.
In the first chapter Anderson himself describes the study of
the kinetics of catalytic reactions in 40 pages. The 2nd chapter, by W. B. Innes, concerns physical adsorption and chemisorption, also the determination of surface area and pore
structure of the catalyst (49 pages). In the 3rd chapter,
comprising 65 pages, P. M. Gundry and F. C. Tompkins treat
the determination of surface potentials and their use for
problems in catalysis. The 4th chapter, by R. S. Hansen and
N. C. Gardner, provides a summary, in 45 pages, of field
electron and field ion microscopy. The 5th chapter is devoted
to chemisorption in ultra high vacuum systems; here, in
45 pages, R. S . Hansen and V. J . Mimeault describe flash desorption spectrometry and give a brief section on evaporated
films and electronic action between their surface and adsorbed
foreign molecules. Diffraction of slow electrons is treated in
chapter 6 (20 pages) by H. E. Farnsworth. In the 7th chapter
T. J. Gray concerns himself with measurement of semiconduction and photoconduction and the catalyst properties
connected therewith (34 pages). The study of vibration and
electronic spectra of adsorbed molecules is described by G.
Blyholder in chapter 8 (36 pages). In chapter 9, W . S . Goldstein devotes 38 pages to the measurement of the acidity of
catalyst surfaces. In the 32 pages of chapter 10, L. J. E. Hofer
describes the magnetochemical methods and their use in
research on catalysis. R . J. Kokes presents electron spin
resonance and its use in problems of catalysis (37 pages).
The older methods of investigating catalysts by diffraction of
X-rays and fast electrons are not reported, nor are applications of the electron probe microanalyzer, X-ray absorption,
or the Mossbauer effect, or the study of electrode reactions.
Each chapter is provided with a list of references, treating
English-language literature up to about 1966 but (with three
exceptions) the German only up to 1960.
As a whole the book gives a useful comprehensive survey of
modern physicochemical methods for research on catalysis.
R . Suhrniann [NB 831 IE]
Solid Phase Peptide Synthesis. By J. M. Stewart and J. D .
Young. W. H. Freeman and Co., San Francisco-London
1969. 1st Edit., xi + 103 pp., 28 illustrations, bound 48s.
Within a few years of the first publication, solid-phase
peptide synthesis, often called Merrifield synthesis after its
discoverer Bruce MerriJield, has achieved a firm place in most
laboratories concerned with the synthesis of peptides or
proteins. The culmination to date is the synthesis, by Merrifieid and Bernd Gutte early in 1969, of an enzyme preparation
with ribonuclease activity. As is now well known, the principle of this method is to build a linear peptide by chainlengthening, unit by unit, from the carboxyl end while keeping
the peptide chain anchored covalently, e.g., by an ester bond,
to a solid phase until the synthesis is complete. Sequencepure peptides, i.e. peptides with the desired sequence throughout, can, however, be obtained only if each peptide bond is
formed in 100 % yield and if the selective protecting groups
on the N-terminal amino acid are completely removed while
the side-chain functions remain protected until the end of the
synthesis.
Merrifield syntheses have split chemists working on peptide
synthesis into two camps: one group hopes for rapid solution
of all the synthetic problems by the new method and sees the
time coming when sequence-pure peptides will be synthesized
automatically in gram quantities; the other considers it impossible in principle to prepare sequence-pure peptides with
more than a definite but as yet undetermined number of
amino acid units.
The present is thus a very opportune time for Stewart and
Young’s book. It will help everyone wanting to synthesize
peptides by the Merrifield method, not only by explaining
the theoretical basis of each operation (pages 1-26) but also
by providing clear experimental details (pages 27-70) for
this method. The book is written with exemplary clarity and
the illustrations are of excellent quality. It is directed in the
first place to those interested in solid-phase synthesis, but the
Reviewer recommends this “Gattermann of peptide synthesis” to everyone with any interest in amino acids and peptides. Although we already have excellent textbooks and
reference works for peptide chemistry, such as those by
Bodansky and Ondetti (1966) and Schroder-Liibke (1965,
1966), we must nevertheless welcome a laboratory book that
covers the literature between those dates and the beginning
of 1968 and describes, e.g., in detail Sukakibara’s method for
removal of almost all protecting groups by means of hydrofluoric acid.
This unrestricted recommendation is not weakened by
mention of the very fragmentary citation of European
literature; this can be remedied in the next edition if Merrifield specialists will heed the author’s request to keep them
informed of new papers.
H . Zahn [NB 834 IEI
Registered names. trademarks, etc. used in this journal, even wifhour specific indicatron thereof, arc nof to be considered unprotected by law.
0 Veriag Chemie, GmbH. Weinheim 1969. - Printed in Germany by Druckerei Winter, Heidelberg.
All rights reserved. No part of this journal may be reproduced in any form whatsoever, e.g. by photoprint. microfilm, or any other means. without
written permission from the publishers.
Editorial office: Ziegelhauser Landsvasse 35. 6900 Heidelberg 1, Germany, Telephone 45075, Telex 46 1855 kemia d, Cable address: Chemieredaktion
Heidelberg.
.
Editor: H. Grlinewdd Translation Editors: A. J. Rackstraw and A. Srimson.
Publishers: Verlag Chemie GmbH. (Presidents JErgen Kreuzhage and Hans Schermer). Pappelallee 3, 6940 Weinheim/Bergstr., Germany, and
Academic Press Tnc. (President W a k r J . Johnson). 1 1 1 Fifth Avenue, New York 3, N.Y., USA, and Berkeley Square House, Berkeley Square,
London, W. l., England.
Correspondence concerning advertisements should be addressed t o Verlag Chemie, GmbH. (Advertising Manager W.Thiel), 6940 WeinheidBergstr.,
PappeIallee 3, Germany, Telephone Weinheim (06201) 3635, Telex 4655 16 vchwh.
932
Angew. Chem. internat. Edit.
Vol. 8 (1969) NO.I I
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