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Book Review Structure Elucidation of Natural Products by Mass Spectrometry. Vol. I Alkaloids. By H. Budzikiewicz C. Djerassi and D. H

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chapters the fundamentals discussed i n the introductory chapters are considered in more detail; repetitions have largely
been avoided, and the symbols used have all been standardized
throughout the text.
This volume makes it possible to secure rapid familiarity with
the methods of optical analysis and to obtain reliable information on the scope and limitations of their application. The
complete work promises to become the standard handbook of
analytical chemistry, and probably will be soon found in every
chemical library.
W.Liptny [NB 2641122 IE]
Structure Elucidation of Natural Products by Mass Spectrometry. Vol. I : Alkaloids. By H. Eudzikiewicz, C. Djerassi,
and D . H. Williams. Holden-Day Series in Physical Techniques in Chemistry. Holden-Day Inc., San FranciscoLondon-Amsterdam 1964. 1st edit., xi + 233 pp., numerous
illustrations, linen $10.50.
The present volume contains a detailed discussion of the mass
spectrometry of alkaloids, especially of those of the indole
and isoquinoline series. Although the book has therefore a
highly specialized character, it is of general significance since
i t contains a chapter o n deuteration procedures. I n this remarkable section, a comprehensive collection of methods for
marking organic compounds with deuterium is given with
numerous examples. In their later discussion on the massspectrometric degradation of alkaloids, the authors presume
that the charge o n the molecule ion - e.g. o n a nitrogen atom
- is localized. All the degradation mechanisms are formulated according to this principle in the present volume, although this approach sometimes leads to structural formulae
for the degradation products, which are unacceptable from
the energy standpoint. Thus, for example, the fragment p
from a pyrrolizidine alkaloid shown o n p. 223 is formulated
as a diradical cation, and the energetically much more favorable, and thus more probable simple cation is not even considered.
A few careless errors probably result from the rapid appearance of the book (only three months after completion of the
general first part), but these will be certainly corrected in any
future edition.
Despite these faults, the book can be recommended as being
the first detailed review of the mass-spectroscopy of the alkaloids, and it well deserves a place in every laboratory devoted to mass-spectroscopic investigations of these compounds.
G. Spiteller [ N B 2891147 IE]
The Mitochondrion. Molecular Basis of its Structure and
Function. By A. L. Lehninger. W. A. Benjamin, Inc., New
York-Amsterdam 1964. 1st edit., xx + 263 pp., numerous
illustrations, and some tables, linen $9.90.
Although classical cell research was in a position to define
mitochondria both morphologically and functionally at the
beginning of this century, research proper on these subcellular
particles which are responsible for energy metabolism in the
cell only began with the development of modern biochemical and biophysical methods after the Second World
War. Today the beginnings of the elucidation of the molecular function and structure of mitochondria are recognizable.
A decisive contribution to this development was made by A .
L. Lehninger with his discovery of the participation of mitochondria in the oxidation of fats and in oxidative phosphorylation. In the present volume he presents the first summary of
the current state of research and of the molecular basis of
mitochondria1 structure and function. The subject matter is
discussed in detail, and comprises mitochondria in the intact
cell, the oxidative cycles and the respiratory chain, the components of the oxidative system and of oxidative phosphorylation, problems of control, compartmentation, and integration, as well as further questions related to active ion-transport, water balance, and biogenesis. The book is well illustrated and contains much unabridged material taken directly
from representative authors in this field, and abundant references to review articles and important journal publications
are also included. It forms an excellent introduction for those
who wish to acquaint themselves with the problems involved
in this field, and should also be welcome as a work of reference for the expert o n this subject.
E. Hess [NB 2911149 IE]
Registered names, tradernarlcs, etc. used in this journal, even without specific indication thereof, are not t o be considered unprotected by l a w
1965 by Verlag Chemie, GmbH. - Printed in Germany by Druckerei Winter, Heidelberg.
All rights reserved. N o part of this journal may be reproduced in any form whatsoever, c . g . by photoprint, microfilm, or any other means. without
written permission from the publishers.
Editorial Office: Zieselhauser Landstrasse 35, Heidelbers, Germany. Telephone 24975, Telex 04-61 855, Cable addrsss: Chemieredaktion Heidefberg.
Chief Editor: JV. Forrsf . Editor: H. Griinpwnld.
Publishers: Verlas Cheniie GmbH. (President Edward Kreuzlragr), Pappelallee 3, WeinheimIBergstr., Germany, and Academic Press Inc. (President
Walter J. Johnson), 1 I 1 Fifth Avenue, New York 3, N.Y., U.S.A., and Berkeley Square House, Berkeley Square, London, W . I . England.
Correspondence concerning advertisements should by addressed to VerlagChemie, GmbH. (Advertising Manager W.Thiel),Pappelallee 3, Weinheim/
Bergstr., Germany, Telephone Weinheim 3635, Telex 01-65 51 6. Cable address: Chemieverlag Weinheimbergstr.
Angew. Chem. in&ernat.Edit. / Vol. 4 11965)
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