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Book Review Structure-Solubility Relationships in Polymers. Edited by F. W. Harris and R. B. Seymour

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Each chapter includes a long list of references covering
the literature up to 1974. The value of the book is enhanced
by the many figures, diagrams, and tables correctly fitted
into the text. The worked examples in the individual chapters
facilitate understanding of the material.
The book is a readable and comprehensive survey of the
technique of gas-solid reactions, and is recommended to
anyone who wants to understand this field.
Ruiner Moormann [NB 402 IE]
Modern Practice of Chromatography. By R . L. Grob. John
Wiley & Sons, Ltd., New York-London
1977. 1st Edit.,
xv, 654 pp., numerous figs., bound, f 16.00.
This work, edited by Robert L. Grob, is the most comprehensive existing collection of contributions on the applications of
gas chromatography. The individual chapters, written by experienced specialists, describe in three main parts (and in great
detail, but not always with consideration of the most recent
literature-capillary gas chromatography is mentioned only
marginally in the theoretical part) the theory, the technology,
and the applications of gas chromatography. About two-thirds
of the volume are devoted to theory, qualitative and quantitative analysis, description of apparatus, procedures for sample
injection, detectors, and computers. This is the first book
to collect so completely such a large number of new technical
developments. Emphasis should be laid on the chapters about
detectors, instrumentation, and data collection; great advances
have been made in recent years in these areas. The chapter
dealing mainly with applications includes trace analysis (environmental analysis), examination of foods, clinical analysis,
and analysis of drugs, for which work standard methods have
been worked out for preparation of the samples and formation
of derivatives as well as standardized conditions for separations; therein lies the particular value of this section. Minor
redundancies have not been wholly avoided in the text.
The book is supplemented by a chapter on physicochemical
applications of gas chromatography, where the posssible
application of gas chromatography to the determination of
thermodynamic quantities is pointed out, a feature rarely
known to the analyst and yet of great interest.
This volume, well worth its price, offers the user of gas
chromatography in a wide range of fields a wealth of experience and stimulation.
Wilfried A . Kijnig [NB 412 IE]
StructureSolubility Relationships in Polymers. Edited by F.
W Harris and R . B. Seymour. Academic Press, New York
1977. 1st Edit., xiii 271 pp. bound, $ 13.00.
A symposium with the same title was held by the American
Chemical Society-their 172nd-between August 30 and September 3, 1976. The revised and shortened versions of 21
lectures delivered there were collected in book form and
printed by Academic Press Rapid Reproduction. This has
given us a book which is up to date and gives a representative
cross-section of research in this field.
The summarizing contributions have retained their lecture
character; modem solubility theories are discussed in conjunction with the experimental results in easily comprehensible
form, and at the same time more emphasis is placed on outlining the problems involved, thus making them also accessible
to those who do not work in this field. In addition, the
large number of references listed make further reading possible.
The authors work in a variety of places, ranging from
industrial laboratories to universities, and therefore some of
Angew. Chem. Int. Ed. Engl. I 7 ( 1 9 7 8 ) No. 4
the polymers discussed are unusual as model substances. This
is an advantage for the reader, because he can follow the
development of the problem and treatment from the specific
characteristics of the polymer in question.
The editors have succeeded in giving a picture of current
knowledge in a limited space. From the very beginning, the
book is suitable for the interested reader who works with
polymers in general, while for the specialist it presents a
broad basis for future research.
K . C. Berger [NB 404 IE]
BlutzuckersenkendeSulfonamide- Standort der modernen Substanzen im Vergleich zu alteren Antidiabetika (Hypoglycemic
Sulfonamides-Status of Modern Substances Compared
with Older Antidiabetic Agents). By E. Haupt. Verlag Chemie, Weinheim-New York 1977. 1st edit., viii, 169 pp.,
58 figs., 3 tables, boards, D M 34.-.
The author’s Habilitation Thesis, now presented in book
form, is an attempt to define the position of hypoglycemic
sulfonamides on the basis of pharmacodynamic, clinical, and
experimental-clinical investigations. The history of the discovery and development of this class of substances is reported
in an introductory chapter, where, however, the important
development work carried out during 1951-1953 at the Leipzig and Jena university clinics (literature in A . Kleinsorge,
Dtsch. Med. Wochenschr. 101, 467 (1 976)) was conspicuous
by its absence.
The following sulfonylurea derivatives were investigated
in the present study: tolbutamide, glibornuride, glisoxepide,
and glibenclamide. The important results include the following: no differences were noticeable on oral administration
in the kinetics of insulin secretion or in the course of the
blood sugar curves; these findings apply both to healthy subjects and to diabetics. Secondary failure of the sulfonylurea
monotherapy occurred to the same extent with all the derivatives studied; the “younger-generation’’ preparations active
in milligram doses did not differ in this respect from the
older substances. Secondary failure occurred mostly in patients
who were severely overweight. The time at which failure occurs
depends on the duration of the diabetes therapy and not
on the time of appearance of the diabetes mellitus. Each
year 5-10 % of all treatments must be broken off because
of secondary failure. In the pharmacological investigations,
glibenclamide given intravenously had a different effect from
the other substances: it induced a distinct insulin secretion,
of delayed onset and long duration, with corresponding later
decrease of blood sugar (this effect occurred in both healthy
and diabetic persons). It is still unclear why the action of
glibenclamide is “tolbutamide-like” on oral administration
and “glibenclamide-like” when injected intravenously. The
difference from literature findings that indicate specific glibenclamide action also by the oral route still requires explanation
(cf. S. Raptis et a/.: 8th Kongr. Dtsch. Diab. Ges., Munich
Clinical importance attaches to the discussion of the problem of secondary failure; it confirms the finding that the
insufficiency of pancreatic p cells, at first incomplete, later
becomes complete. An appeal is made to diabetics specialists
in clinical and general practice to compensate patients under
positive long-term treatment with weight reduction, so that
the secondary failure may be delayed.
Those interested in this book will be especially doctors
and chemists concerned with sulfonylurea derivatives in industrial and other research laboratories.
Friedrich Wi/lig [NB 415 IE]
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