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Book Review Two-Dimensional NMR Spectroscopy. (Methods in Stereochemical Analysis. Vol.9.) Edited by W. R. Croasmun and R. M. K. Carlson

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tate ligands (0 or C bonded), as bridging ligands, as allyltype q’-ligands, o r in a wide variety of ways as dianions.
The structures, spectroscopic properties and reactions are
discussed in detail, and published work u p to 1985 is COVered, with occasional references to more recent papers.
On balance, this book contains much less than its allembracing title suggests. Half of the costly space (DM 1.00
per page!) is taken u p by information which one can find
equally well or better in standard textbooks. The claim t o
completeness is only justified in the case of the overview of
p-diketone complexes, but that is already available in every
well stocked library.
Wolfdieter A . Schenk [NB 917 IE]
Institut fur Anorganische Chemie
der Universitat Wurzburg (FRG)
Two-Dimensional NMR Spectroscopy. (Methods in Stereochemical Analysis. Vol. 9.) Edited by W . R. Croasmun
and R . M . I(. Carlson. VCH Verlagsgesellschaft, Weinheim/VCH Publishers, New York 1987. 511 pp., bound,
DM 2 10.00.- ISBN 3-527-26528-7/0-89573-308-0
During the last decade nuclear magnetic resonance
(NMR) has become one of the main spectroscopic tools in
research laboratories for structural analysis of biological
and chemical compounds. Several factors have contributed
to the increase in popularity of NMR. The construction of
high-field N M R magnets and the use of modern computers in NMR spectrometers were a prerequisite. However,
the major advances came from the development of the
two-dimensional (2D) N M R method by Ernst and coworkers, and the sequencial assignment strategy for proteins by
Wiithrich and coworkers. The rapid growth of the N M R
field has led to impressive scientific results, published initially in scientific journals. In addition, in the past two
years a number of good books o n various subjects and at
various levels have been published. For expert N M R spectroscopists, for example, there appeared the texts of Ernst
et al. (“Principles of Nuclear Magnetic Resonance in One
and Two Dimensions”, Clarendon 1987) and Wiithrich
(“NMR of Proteins and Nucleic Acids”, Wiley-Interscience 1986), while for students a number of suitable
NMR textbooks have been published in England ( R . K .
Harris and A . E. Derome. o r J. K . M . Sanders and B. K .
Hunter). Any new book explaining 2 D N M R techniques
faces the difficult task of having to compete with these
Croasmun and Carlson, researchers at two large industrial laboratories, have edited a new volume of the “Methods in Stereochemical Analysis” series, which is devoted
entirely to 2 D N M R and contains contributions from various authors. The book is aimed at chemists and biochemists who are not N M R spectroscopists, but who may want
to apply 2D N M R to their field of interest. However, it is
doubtful whether this volume is really attractive for readers other than researchers who already use N M R techniques. It is certainly not recommended as a general introduction to 2 D NMR, for which purpose the books mentioned previously are much more suitable. Nevertheless,
the volume contains a number of reviews which are certainly worthwhile reading. Horst Kessler’s group have reviewed their extensive 2 D N M R studies of the cyclic peptide Cyclosporin A, and compare various experimental
techniques for assigning the resonances and extracting Jcoupling parameters from 2 D spectra. In another fine
chapter, David Kearns describes the internal motions in
Angew. Chem Int. Ed. Engl. 27(1988) No. I 1
D N A and their effects on the relaxation parameters as
measured by NMR, and summarizes his 2D N M R studies
of simple-sequence DNAs such as poly(dA-dT). poly(dAdT). Janusz Dubrowski reviews the application of 2 D N M R
in the structural analysis of oligosaccharides, and demonstrates the usefulness of N M R in this area. Furthermore,
the book contains three chapters on the use of 2 D techniques in studies of natural products. William Croasmun
and Robert Carlson have written a chapter o n steroid structure analysis by 2 D NMR, Gary Martin has done the same
for coal-derived heterocyclics, terpenoids and alkaloids,
while Peter Rinaldi compares the characterization of an intermediate in the organic synthesis of spatol using several
different high- and low-field 2 D N M R experiments.
However, the outstanding chapter, and also the longest
(more than 150 pages), on the experimental aspects of 2 D
NMR, is written by William Hull. This chapter gives a
clear treatise on good 2 D practice, and an insight into
many 2 D pulse sequences and their phase cycles. It is by
virtue of this chapter that I would recommend keeping the
book beside your 2 D N M R spectrometer (even if it isn’t a
Bruker). Unfortunately, the book is dated, which is not
very harmful for the last mentioned contribution, but more
so for the other chapters on research topics, since N M R
has developed very rapidly in the last few years. Most references d o not extend beyond 1985 or the start of 1986,
and it is rather unfortunate that the publisher was unable
to bring it out at the end of 1986 o r early 1987. In general,
the book is rather specialized; it will probably find its way
into major university libraries o r research institutes.
RolfBoelens [NB 900 IE]
Department of Organic Chemistry
University of Utrecht (Netherlands)
Silicon Reagents in Organic Synthesis. (Series: Best Synthetic Methods.) By E . Colvin. Academic Press, New
York 1988. xxii, 147 pp., bound, E 27.00.-ISBN 0-12182560-4
A report o n the new series “Best Synthetic Methods”
has already appeared.[*’ The fourth volume has now been
published; this is quite a slim one with 140 pages of text,
dealing with silicon as a key element in organic syntheses.
The author, E. Colvin, has already set standards in this
field several years ago with his excellent monograph “Silicon in Organic Synthesis” (Butterworth, London 1981).
The present volume follows the well proven division of
the subject that was used in the previous work. A general
introduction to the chemistry of silicon compounds is followed by representative examples of the various compound classes and types of reactions (e.g., vinylsilanes, allylsilanes, silyl anions, silyl enol ethers, the Peterson olefination, etc.). The lists of relevant review articles and the
inclusion of information about suppliers of organosilicon
intermediates are very useful features; however, both of
these are treated from an English-speaking viewpoint, so
that, for example, the Houben-Weyl volume on silicon is
missing from the list of publications.
The treatment of individual compound classes includes,
in addition to detailed schemes showing syntheses and
reactivity, very useful experimental details for carrying out
many of the typical transformations; each chapter ends
with a list of literature references. The last chapter con-
[*] See Angew. Chem. Int. Ed. Engl. 26 (1987) 593.
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