American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 141B:429 (2006) Commentary Comment on the Use of Genetic Findings on Schizophrenia Please cite this article as follows: DeLisi LE. 2006. Comment on the Use of Genetic Findings on Schizophrenia. Am J Med Genet Part B 141B:429. Dear Editors: Dr. Austin, a genetic counselor, has commented on the evidence-based data presented in our manuscript [DeLisi and Bertisch, 2006]. I believe she focuses on some interesting points: (1) that those who say they would want to have genetic testing do not necessarily go for testing when available and; (2) that there is commercial genetic testing that will soon be available—and MUCH TOO SOON—for schizophrenia. Particularly the latter is very worrisome as there is NO definitely proven genetic variation that increases risk for schizophrenia. Although several genes are now candidates, results about SNPs in these genes and corresponding haplotypes for risk are still too inconsistent across studies to make any of them valid for commercial use. In addition, even if there were certain risk factors, the risk conferred is so small as not to make these genetic variations candidates for genetic testing and would only serve to scare families unnecessarily. As is shown in DeLisi and Bertisch , already families are frightened into thinking that they should avoid having *Correspondence to: Lynn E. DeLisi, M.D., Professor of Psychiatry, 650 First Avenue, New York, New York 10016. E-mail: DeLisi76@AOL.com Received 24 January 2006; Accepted 24 January 2006 DOI 10.1002/ajmg.b.30312 ß 2006 Wiley-Liss, Inc. children for fear of passing the defective gene to offspring and this is unrealistic given the statistics that the scientists surveyed know. This is why very few of the researchers in that study thought testing would provide useful information or that first degree relatives of someone with schizophrenia should avoid having children. In summary, commercial genetic testing for schizophrenia is not, and may never be scientifically reasonable. The importance of genetic research on schizophrenia and other psychiatric illnesses as well, is for understanding the pathophysiological basis of the illness so that a new generation of etiologically based treatments for eventual early detection and prevention of illness can be developed. Lynn E. DeLisi* Professor of Psychiatry New York University School of Medicine New York, New York REFERENCE DeLisi LE, Bertisch HC. 2006. A preliminary comparison of the hopes of researchers, clinicians, and families for the future ethical use of genetic findings on schizophrenia. Am J Med Genet Part B: Neuropsychiatr Genet 141B:110–115.