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Table. Cerebellar P/Q-Type and N-Type VGCC Content in PCD-LEMS and Disease Control Patients Using Binding Studies
Serum VGCC Antibodies
(pmol/L)
Cerebellar VGCC Content
(fmol/mg)
Patient
Age/Sex
Disease
P/Q-Type
N-Type
P/Q-Typea
N-Typeb
1
2
3
4
5
6
7
8
9
79/M
69/M
74/F
82/F
78/F
85/F
64/F
35/F
22/F
PCD-LEMS
PCD-LEMS
PCD-LEMS
LEMS
ALS
ALS
Lung cancer
ARDS
Encephalitis
1,010
1,449
524
782
⬍1.0
⬍1.0
⬍1.0
⬍1.0
⬍1.0
⬍1.0
⬍1.0
⬍1.0
⬍1.0
⬍1.0
⬍1.0
⬍1.0
⬍1.0
⬍1.0
49.0
38.3
80.4
377.6
360.8
272.1
230.3
220.3
188.6
16.4
1.60
30.32
53.0
6.52
24.1
12.0
6.67
5.53
a
Specific binding of 100pM
Specific binding of 100pM
b
125
I-␻-conotoxin MVIIC.
I-␻-conotoxin GVIA.
125
VGCC ⫽ voltage-gated calcium channel; PCD ⫽ paraneoplastic cerebellar degeneration; LEMS ⫽ Lambert–Eaton myasthenic syndrome;
ALS ⫽ amyotrophic lateral sclerosis; ARDS ⫽ adult respiratory distress syndrome.
1
First Department of Internal Medicine, Nagasaki University
School of Medicine, 2Nagasaki Kita Hospital, 3School of
Health Sciences, Nagasaki University, Nagasaki; and
4
Department of Medical Oncology, Hokkaido University
Graduate of Medicine, Sapporo, Japan
References
1. Fukuda T, Motomura M, Nakao Y, et al. Reduction of P/Q-type
calcium channels in the postmortem cerebellum of paraneoplastic
cerebellar degeneration with Lambert-Eaton myasthenic syndrome. Ann Neurol 2003;53:21–28.
2. Mason WP, Graus F, Lang B, et al. Small-cell lung cancer, paraneoplastic cerebellar degeneration and the Lambert-Eaton myasthenic syndrome. Brain 1997;120:1279 –1300.
3. Motomura M, Lang B, Johnston I, et al. Incidence of serum
anti-P/O-type and anti-N-type calcium channel autoantibodies
in the Lambert-Eaton myasthenic syndrome. J Neurol Sci 1997;
147:35– 42.
DOI: 10.1002/ana.10690
278
Annals of Neurology
Vol 54
No 2
August 2003
Corrections
Katzenschlager R, Costa D, Gerschlager W, O’Sullivan
J, Zijlmans J, Gacinovic S, Pirker W, Wills A, Bhatia
K, Lees AJ, Brown P. [12I]-FP-CIT-SPECT demonstrates dopaminergic deficit in orthostatic tremor. Ann
Neurol 2003;53:489 – 496.
The published formula on page 493 (Table 2) reads
as follows: Asymmetry index: [(R ⫺ L)/(R ⫹ L)/2] ⫻
100, R ⫽ tracer uptake right striatum (PD: more affected side), L ⫽ left striatum (PD: less affected side):
but in fact should have read (R ⫺ L)/(R ⫹ L) ⫻ 2 ⫻
100.
Hamosh A, Van Hove J. Concerns regarding transience and heterozygosity in neonatal hyperglycinemia.
Ann Neurol 2003;53:685.
Please note the collect spelling of “hyperglycinemia”
in the article listed above. It was spelled incorrectly as
it appeared in the May 2003 issue of the Journal.
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