Cover Picture Autonomous Fueled Mechanical Replication of Nucleic Acid Templates for the Amplified Optical Detection of DNA (Angew. Chem. Int. Ed. 142006)код для вставкиСкачать
Cover Picture Yossi Weizmann, Zoya Cheglakov, Valeri Pavlov, and Itamar Willner* A catalytic cutter for the sensitive detection of a target DNA, a Tay–Sachs disorder mutant, is described by I. Willner and co-workers in their Communication on page 2238 ff. As the cover picture shows, a tailored nucleic acid hairpin probe (top) is opened upon hybridization with the analyte DNA, activating the formation of the DNA cutter (central structure), which initiates the autonomous scission of a fuel substrate that leads to the replication of the catalytic cutter and to the formation of a fluorescent product as an optical readout signal. Organometallic Catalysis Metal vinylidenes and allenylidenes are involved in numerous catalytic processes, such as alkene metathesis and coupling reactions. The state of the art in this field is summarized by C. Bruneau and P. H. Dixneuf in their Review on page 2176 ff. Nanoparticle Assemblies In their Communication on page 2204 ff., H. F. Sleiman and F. A. Aldaye describe the use of DNA to mediate the organization of gold nanoparticles—an approach that can be generalized for the sequential and modular generation of a range of nanoparticle patterns. Nanobiotechnology Collagen mimetic peptide functionalized nanoparticles form stable adducts with collagen fibers. In their Communication on page 2267 ff, S. M. Yu et al. describe the binding interactions between the peptide and type I collagen fibers.