Cover Picture Cari D. Pentecost, Andrea J. Peters, Kelly S. Chichak, Gareth W. V. Cave, Stuart J. Cantrill, and J. Fraser Stoddart* Chirality is transferred from 12 stereogenic centers, all of the same chirality, to the six templating zinc(II) ions in each enantiomer of an optically active Borromeate. Recognizing that the three-component Borromean link is topologically achiral, J. F. Stoddart et al. describe in their Communication on page 4099 ff. the dynamic stereospecific synthesis of both all-R and all-S enantiomers of the Borromeate and report the X-ray crystal structure of the all-R enantiomer. Biomolecular Modeling In their Review on page 4064 ff. W. F. van Gunsteren et al. introduce the basis for computational methods that describe the conformational dynamics in oligopeptides and related biomolecules. Graft Polymerization and Switching An optically reversible switching membrane surface is developed by G. Belfort and co-workers as described in their Communication on page 4094 ff. They combine their UV grafting process with the photoresponsive properties of spiropyran molecules. Protein Modifications B. Koksch et al. study in their Communication on page 4198 ff. the influence of fluoro substituents in the amino acid side chains on the interactions of a native polypeptide. The fluorination of alkyl groups has electrostatic and steric consequences for the stability of hydrophobic protein interactions.