Cover Picture Cluster Disorder and Ordering Principles in Al-Stabilized УLaIФ (Angew. Chem. Int. Ed. 252005)код для вставкиСкачать
Cover Picture Oliver Oeckler, Thomas Weber, Lorenz Kienle, Hansjrgen Mattausch, and Arndt Simon* Diffuse diffraction data from disordered compounds can be interpreted with new numerical algorithms; however, there are few examples of quantitative structure refinement against all data and not only Bragg reflections. In the Communication on page 3917 ff., the authors demonstrate the application of evolutionary algorithms to solve the structure of an aluminum-stabilized lanthanum subiodide. The cover picture shows a diffraction pattern of the compound in the background and a section of the disordered structure model in the center. Medicinal Chemistry Protein tyrosine phosphatases have been analyzed as targets for therapeutic intervention for several years. H. Waldmann and L. Bialy discuss recent research activities in the development of small-molecule inhibitors of these enzymes in their Review on page 3814 ff. Molecular Dynamics Molecular clusters formed by hydrogen bridges can be highly dynamic systems, as described for a fluoromethane–trifluoromethane complex by W. Caminati et al. in their Communication on page 3840 ff. Bioorganic Chemistry Pathogenic bacteria that produce metallo-b-lactamases are recognized as a serious threat because of their resistance to antibiotics. In their Communication on page 3861 ff. H. Kurosaki et al. introduce an irreversible inhibitor for the metallo-blactamase IMP-1.