Cover Picture Glycoviruses Chemical Glycosylation Retargets Adenoviral Gene Transfer (Angew. Chem. Int. Ed. 72005)код для вставкиСкачать
Cover Picture Oliver M. T. Pearce, Kerry D. Fisher, Julia Humphries, Leonard W. Seymour,* Alberto Smith, and Benjamin G. Davis* Sugar-specific mechanisms of cell transfection can be created by the controlled glycosylation of the surfaces of adenoviruses, which have an icosahedral structure, as depicted in the cover picture. In their Communication on page 1057 ff., L. W. Seymour, B. Davis, and co-workers describe how derivatives of adenoviruses with galactose or mannose selectively transfect human macrophages rather than the standard human endothelia and how this dramatic retargeting holds promise for gene therapy. Natural Products Synthesis To err is human! Even with modern analytical methods mistakes can be made in the structural elucidation of natural products. K. C. Nicolaou and S. A. Snyder show how chemical synthesis can help to solve these molecular puzzles in their Review on page 1013 ff. Enzyme Selection In their Communication on p. 1048 ff. S. Q. Yao et al. describe a new method for the simultaneous selection of mRNA-bound enzymes and for their identification with the aid of a DNA-microarray. Phosphorus Compounds A simple access to the rare b-functional phosphinine compounds from readily available phospholide ions is described by F. Mathey and J. Grundy in their Communication on p. 1082 ff.