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Cover Picture Kinetically Controlled Ligation for the Convergent Chemical Synthesis of Proteins (Angew. Chem. Int. Ed. 242006)

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Cover Picture
Duhee Bang, Brad L. Pentelute, and Stephen B. H. Kent*
Convergent chemical ligation enables the more efficient total synthesis of protein
molecules. S. B. H. Kent and co-workers describe in their Communication on
page 3985 ff. how the two halves of the target peptide chain can be synthesized by
kinetically controlled chemical ligation of unprotected peptide segments. A final
native chemical ligation step then gives the full-length polypeptide chain, which folds
with high efficiency to give the synthetic protein molecule. (The artwork for the
coverpicture was prepared by David Boerema.)
The Review by M. M. Haley and C. W. Landorf on page 3914 ff. concerns
metallabenzenes. Structural and NMR spectroscopic properties are as much a focus as
the reactivity of metallabenzenes and the mechanisms of their syntheses.
Chemoenzymatic Synthesis
Sialic acid exists in 50 structurally distinct forms in naturally occurring structures. X.
Chen et al. describe in their Communication on page 3938 ff. how sialosides with
natural and non-natural sialic acid forms have been prepared.
cis–trans Isomerization
In their Communication on page 3996 ff., L.-J. Wan et al. describe how thermal
annealing transforms the molecular symmetry of an adlayer from lamellar to
hexagonal which causes a trans-to-cis isomerization of the molecules within the
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kinetically, int, cover, angel, synthesis, chemical, ligation, chem, protein, 242006, controller, picture, convergence
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