Cover Picture Molecular Recognition of a Three-Way DNA Junction by a Metallosupramolecular Helicate (Angew. Chem. Int. Ed. 82006)код для вставкиСкачать
Cover Picture Aneta Oleksi, Alexandre G. Blanco, Roeland Boer, Isabel Usn, Joan Aymam , Alison Rodger, Michael J. Hannon,* and Miquel Coll* Metallosupramolecular helicates with trigonal-antiprismatic geometry thread through and fit perfectly into the central hydrophobic cavity of a three-way DNA junction. Six hydrophobic rings of the drug stack on six DNA bases, with three more sandwiched in the minor grooves. This work reveals and enables a new approach to targeting DNA and specifically DNA junctions. For more details, see the Communication by M. Coll, M. J. Hannon, and co-workers on page 1227 ff. Sensors The molecular recognition between an external signal and a receptor is transduced allosterically to catalytically amplified chemical information. E. V. Anslyn and L. Zhu outline this approach in their Minireview on page 1190 ff. Medicinal Chemistry Polymeric carrier systems enable the optimization and transport of low-molecularweight drugs, proteins, and oligonucleotides. Current developments in polymer therapeutics are given by R. Haag and F. Kratz in their Review on page 1198 ff. Metathesis Catalysts In their Communication on page 1216 ff., C. Cop6ret and co-workers describe the preparation of a silica-supported Mo–carbene catalyst for olefin metathesis and how its performance compares relative to its molecular equivalent.