Cover Picture Multicenter Strategy for the Development of Catalytic Enantioselective Nucleophilic Alkylation of Ketones Me2Zn Addition to -Ketoesters (Angew. Chem. Int. Ed. 442003)код для вставкиСкачать
Cover Picture Ken Funabashi, Markus Jachmann, Motomu Kanai, and Masakatsu Shibasaki* The Senjyu Kannon statue in the Koufukuji temple in Nara, Japan (see picture), has thousands of hands to manipulate thousands of things at once. A new catalyst, a 2,4-cis-hydroxyprolinol derivative, was developed for the enantioselective addition of dimethylzinc to a-ketoesters. The catalyst has three hands in a cis-stereochemical array, which activates both the ketoester substrate and the organozinc reagent simultaneously. M. Shibasaki et al. describe on page 5489 ff. the excellent enantioselectivities obtained from aromatic and heteroaromatic substrates.