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Cover Picture Multicenter Strategy for the Development of Catalytic Enantioselective Nucleophilic Alkylation of Ketones Me2Zn Addition to -Ketoesters (Angew. Chem. Int. Ed. 442003)

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Cover Picture
Ken Funabashi, Markus Jachmann, Motomu Kanai, and
Masakatsu Shibasaki*
The Senjyu Kannon statue in the Koufukuji temple in Nara, Japan (see picture), has
thousands of hands to manipulate thousands of things at once. A new catalyst, a
2,4-cis-hydroxyprolinol derivative, was developed for the enantioselective addition of
dimethylzinc to a-ketoesters. The catalyst has three hands in a cis-stereochemical
array, which activates both the ketoester substrate and the organozinc reagent
simultaneously. M. Shibasaki et al. describe on page 5489 ff. the excellent
enantioselectivities obtained from aromatic and heteroaromatic substrates.
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development, ketoesters, alkylation, multicenter, 442003, strategy, enantioselectivity, int, cover, angel, chem, catalytic, additional, ketone, me2zn, picture, nucleophilic
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