Cover Picture Organocatalytic Asymmetric Michael Reaction of Cyclic 1 3-Dicarbonyl Compounds and -Unsaturated KetonesЧA Highly Atom-Economic Catalytic One-Step Formation of Optically Active Warfarin Anticoagulant (Angew. Chem. Int. Edкод для вставкиСкачать
Cover Picture Nis Halland, Tore Hansen, and Karl Anker Jørgensen* Optically active anticoagulants are formed in a new one-step organocatalytic asymmetric Michael reaction. The synthesis of the optically active warfarin from simple starting materials is shown. The background is a CT-scanning image of the lungs, where thrombosis can occur. The other images show a heart with a thrombus (left), and the same heart after surgery and treatment with anticoagulant (right), these images can be seen as films in the Supporting Information. Full details are in the Communication by K. A. Jørgensen et al. on page 4955 ff.